Current Issues in Molecular Biology,
Год журнала:
2023,
Номер
45(11), С. 9117 - 9131
Опубликована: Ноя. 14, 2023
Brassica
oleracea
var.
italica
(broccoli),
a
member
of
the
cabbage
family,
is
abundant
with
many
nutrients,
including
vitamins,
potassium,
fiber,
minerals,
and
phytochemicals.
Consequently,
it
has
been
used
as
functional
food
additive
to
reduce
oxidative
stress
inflammatory
responses.
In
current
study,
effects
sulforaphane-rich
broccoli
sprout
extract
(BSE)
on
response
were
investigated
in
vitro
vivo.
Comparative
high-performance
liquid
chromatography
analysis
sulforaphane
content
from
different
extracts
revealed
that
70%
ethanolic
BSE
contained
more
than
other
extracts.
qPCR
enzyme
immunoassay
analyses
markedly
reduced
expression
proinflammatory
cytokines
mediators,
cyclooxygenase
2,
interleukin
(IL)-1β,
IL-6,
IL-1,
inducible
nitric
oxide
synthase
(iNOS),
tumor
necrosis
factor-α
(TNF-α),
lipopolysaccharide
(LPS)-stimulated
RAW
264.7
cells.
Pretreatment
improved
survival
rate
suppressed
alanine
aminotransferase
aspartate
LPS-induced
endotoxemic
mice,
while
such
IL-1β,
TNF-α,
cyclooxygenase-2,
iNOS
decreased
dramatically
liver
injury
model
via
treatment.
Additionally,
F4/80
immunostaining
showed
hepatic
macrophage
infiltration
after
injection.
conclusion,
may
be
potential
nutraceutical
for
preventing
regulating
excessive
immune
responses
disease.
Phytomedicine,
Год журнала:
2023,
Номер
115, С. 154824 - 154824
Опубликована: Апрель 19, 2023
Every
day
the
skin
is
constantly
exposed
to
several
harmful
factors
that
induce
oxidative
stress.
When
cells
are
incapable
maintain
balance
between
antioxidant
defenses
and
reactive
oxygen
species,
no
longer
can
keep
its
integrity
homeostasis.
Chronic
inflammation,
premature
aging,
tissue
damage,
immunosuppression
possible
consequences
induced
by
sustained
exposure
environmental
endogenous
species.
Skin
immune
non-immune
together
with
microbiome
essential
efficiently
trigger
responses
For
this
reason,
an
ever-increasing
demand
for
novel
molecules
capable
of
modulating
functions
in
has
risen
level
their
development,
particularly
field
natural
product-derived
molecules.
In
review,
we
explore
different
classes
showed
evidence
modulate
responses,
as
well
target
receptors
signaling
pathways.
Moreover,
describe
role
polyphenols,
polysaccharides,
fatty
acids,
peptides,
probiotics
treatments
conditions,
including
wound
healing,
infection,
allergies,
aging.
Literature
was
searched,
analyzed,
collected
using
databases,
PubMed,
Science
Direct,
Google
Scholar.
The
search
terms
used
included
"Skin",
"wound
healing",
"natural
products",
"skin
microbiome",
"immunomodulation",
"anti-inflammatory",
"antioxidant",
"infection",
"UV
radiation",
"polyphenols",
"polysaccharides",
"fatty
acids",
"plant
oils",
"peptides",
"antimicrobial
peptides",
"probiotics",
"atopic
dermatitis",
"psoriasis",
"auto-immunity",
"dry
skin",
"aging",
etc.,
combinations
these
keywords.
Natural
products
offer
solutions
conditions.
Significant
anti-inflammatory
activities
were
reported,
followed
ability
skin.
Several
membrane-bound
recognize
diverse
types
natural-derived
molecules,
promoting
improve
Despite
increasing
progress
drug
discovery,
limiting
need
future
clarification.
Understanding
safety,
biological
activities,
precise
mechanisms
action
a
priority
characterization
active
compounds
responsible
that.
This
review
provides
directions
studies
development
new
important
pharmaceutical
cosmeceutical
value.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 2, 2023
Introduction
Fungus-derived
secondary
metabolites
are
fascinating
with
biomedical
potential
and
chemical
diversity.
Mining
endophytic
fungi
for
drug
candidates
is
an
ongoing
process
in
the
field
of
discovery
medicinal
chemistry.
Endophytic
fungal
symbionts
from
terrestrial
plants,
marine
flora,
fauna
tend
to
produce
interesting
types
importance
anticancer,
antiviral,
anti-tuberculosis
properties.
Methods
An
organic
ethyl
acetate
extract
Penicillium
verruculosum
sponge-derived
Spongia
officinalis
yielded
seven
different
which
purified
through
HPLC.
The
isolated
compounds
averufin
(1),
aspergilol-A
(2),
sulochrin
(3),
monomethyl
(4),
methyl
emodin
(5),
citreorosein
(6),
diorcinol
(7).
All
were
characterized
by
high-resolution
NMR
spectral
studies.
compounds',
such
as
antimicrobial,
anti-tuberculosis,
subjected
bioactivity
screening.
Results
Out
tested
compounds,
compound
(1)
exhibits
strong
anticancer
activity
toward
myeloid
leukemia.
HL60
cell
lines
have
IC
50
concentration
1.00μm,
nearly
significant
that
standard
taxol.
A
virtual
computational
molecular
docking
approach
antigens
revealed
binds
strongly
protein
target
alpha,
beta-tubulin
(1JFF),
a
−10.98
binding
score.
Consecutive
OSIRIS
Lipinski
ADME
pharmacokinetic
validation
has
good
properties
score,
solubility,
mutagenic
nature.
Furthermore,
(2)
first
report
on
strain.
Discussion
We
concluded
can
be
taken
further
preliminary
clinical
trials
like
animal
model
in-vivo
studies
pharmacodynamic
future
prospect
screening
validated
present
experimental
findings.
PLoS ONE,
Год журнала:
2024,
Номер
19(7), С. e0304335 - e0304335
Опубликована: Июль 3, 2024
Inflammation
is
an
immune
system
response
that
identifies
and
eliminates
foreign
material.
However,
excessive
persistent
inflammation
could
disrupt
the
healing
process.
Plant-derived
exosome-like
nanoparticles
(PDENs)
are
a
promising
candidate
for
therapeutic
application
because
they
safe,
biodegradable
biocompatible.
In
this
study,
papaya
PDENs
were
isolated
by
PEG6000-based
method
characterized
dynamic
light
scattering
(DLS),
transmission
Electron
Microscopy
(TEM),
bicinchoninic
acid
(BCA)
assay
method,
GC-MS
analysis,
total
phenolic
content
(TPC)
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
assay.
For
in
vitro
test,
we
conducted
internalization
toxicity
assessment,
determination
of
nitrite
concentration,
assessed
expression
inflammatory
cytokine
genes
using
qRT-PCR
RAW
264.7
cells.
vivo
was
induced
caudal
fin
amputation
followed
analysis
macrophage
neutrophil
migration
zebrafish
(Danio
rerio)
larvae.
The
result
showed
can
be
well
optimized
differential
centrifugation
with
addition
30
ppm
pectolyase,
15%
PEG,
0.2
M
NaCl,
which
exhibited
cup-shaped
spherical
morphological
structure
average
diameter
168.8±9.62
nm.
storage
stable
aquabidest
25
mM
trehalose
solution
at
-20˚C
until
fourth
week.
TPC
estimation
all
ages
did
not
show
significant
change,
while
DPPH
test
change
second
major
compounds
contained
Papaya
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one
(DDMP).
internalized
non-cytotoxic
to
Moreover,
LPS-induced
cells
treated
decrease
NO
production
downregulation
mRNA
pro-inflammatory
(IL-1B
IL-6)
upregulation
anti-inflammatory
gene
(IL-10).
addition,
tests
on
inhibition
cell
migration.
These
findings
suggest
possesses
properties.
Foods,
Год журнала:
2023,
Номер
12(14), С. 2740 - 2740
Опубликована: Июль 19, 2023
Chitooligosaccharide
(COS),
found
in
both
insects
and
marine
sources,
has
several
bioactivities,
such
as
anti-inflammation
antioxidant
activities.
However,
the
mechanism
of
shrimp
shell
COS
on
retardation
inflammatory
effects
is
limited.
Therefore,
aim
this
study
to
examine
aforementioned
activities
LPS-activated
RAW264.7
macrophage
cells.
significantly
improved
cell
viability
at
level
500
µg/mL
could
reduce
TNF-α,
NO
IL-6
generations
cells
(p
<
0.05).
Furthermore,
ROS
formation,
NF-κB
overactivation,
phosphorylation
Erk1/2
Akt
Nrf2/HO-1
LPS-exposed
These
results
indicate
that
manifests
anti-inflammatory
activity
action
via
NF-κB,
Erk1/2,
signaling
with
an
increasing
relevance
for
disorders.
Advances in Pharmacological and Pharmaceutical Sciences,
Год журнала:
2024,
Номер
2024, С. 1 - 39
Опубликована: Май 21, 2024
Human
cognition
fundamentally
depends
on
memory.
Alzheimer's
disease
exhibits
a
strong
correlation
with
decline
in
this
factor.
Phosphodiesterase-4
B
(PDE4B)
plays
crucial
role
neurodegenerative
disorders,
and
its
inhibition
is
one
of
the
promising
approaches
for
memory
enhancement.
This
study
aimed
to
identify
secondary
metabolites
white
cabbage,
coffee,
red
onion
extracts
their
molecular
interaction
PDE4B
by
