Cited by Flavonoids as modulators of miRNA expression in pancreatic cancer: Pathways, Mechanisms, And Therapeutic Potential

A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging DOI

Andreia S. Fernandes, Pedro Rodrigues, Manuela Pintado

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 115, P. 154824 - 154824

Published: April 19, 2023

Every day the skin is constantly exposed to several harmful factors that induce oxidative stress. When cells are incapable maintain balance between antioxidant defenses and reactive oxygen species, no longer can keep its integrity homeostasis. Chronic inflammation, premature aging, tissue damage, immunosuppression possible consequences induced by sustained exposure environmental endogenous species. Skin immune non-immune together with microbiome essential efficiently trigger responses For this reason, an ever-increasing demand for novel molecules capable of modulating functions in has risen level their development, particularly field natural product-derived molecules. In review, we explore different classes showed evidence modulate responses, as well target receptors signaling pathways. Moreover, describe role polyphenols, polysaccharides, fatty acids, peptides, probiotics treatments conditions, including wound healing, infection, allergies, aging. Literature was searched, analyzed, collected using databases, PubMed, Science Direct, Google Scholar. The search terms used included "Skin", "wound healing", "natural products", "skin microbiome", "immunomodulation", "anti-inflammatory", "antioxidant", "infection", "UV radiation", "polyphenols", "polysaccharides", "fatty acids", "plant oils", "peptides", "antimicrobial peptides", "probiotics", "atopic dermatitis", "psoriasis", "auto-immunity", "dry skin", "aging", etc., combinations these keywords. Natural products offer solutions conditions. Significant anti-inflammatory activities were reported, followed ability skin. Several membrane-bound recognize diverse types natural-derived molecules, promoting improve Despite increasing progress drug discovery, limiting need future clarification. Understanding safety, biological activities, precise mechanisms action a priority characterization active compounds responsible that. This review provides directions studies development new important pharmaceutical cosmeceutical value.

Language: Английский

Citations

106

Isolation of anticancer bioactive secondary metabolites from the sponge-derived endophytic fungi Penicillium sp. and in-silico computational docking approach DOI

Kumaravel Kaliaperumal, Limbadri Salendra, Yonghong Liu

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 2, 2023

Introduction Fungus-derived secondary metabolites are fascinating with biomedical potential and chemical diversity. Mining endophytic fungi for drug candidates is an ongoing process in the field of discovery medicinal chemistry. Endophytic fungal symbionts from terrestrial plants, marine flora, fauna tend to produce interesting types importance anticancer, antiviral, anti-tuberculosis properties. Methods An organic ethyl acetate extract Penicillium verruculosum sponge-derived Spongia officinalis yielded seven different which purified through HPLC. The isolated compounds averufin (1), aspergilol-A (2), sulochrin (3), monomethyl (4), methyl emodin (5), citreorosein (6), diorcinol (7). All were characterized by high-resolution NMR spectral studies. compounds', such as antimicrobial, anti-tuberculosis, subjected bioactivity screening. Results Out tested compounds, compound (1) exhibits strong anticancer activity toward myeloid leukemia. HL60 cell lines have IC 50 concentration 1.00μm, nearly significant that standard taxol. A virtual computational molecular docking approach antigens revealed binds strongly protein target alpha, beta-tubulin (1JFF), a −10.98 binding score. Consecutive OSIRIS Lipinski ADME pharmacokinetic validation has good properties score, solubility, mutagenic nature. Furthermore, (2) first report on strain. Discussion We concluded can be taken further preliminary clinical trials like animal model in-vivo studies pharmacodynamic future prospect screening validated present experimental findings.

Language: Английский

Citations

Ginsenoside Rh2 promotes hepatic stellate cell ferroptosis and inactivation via regulation of IRF1-inhibited SLC7A11 DOI

Zhichao Lang,

Suhui Yu, Yuhang Hu

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 118, P. 154950 - 154950

Published: July 5, 2023

Language: Английский

Citations

Proteomics and transcriptomics explore the effect of mixture of herbal extract on diabetic wound healing process DOI

Yang Liu, Xi Zhang, Liping Yang

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 116, P. 154892 - 154892

Published: May 24, 2023

Language: Английский

Citations

Isolation and characterization of plant-derived exosome-like nanoparticles from Carica papaya L. fruit and their potential as anti-inflammatory agent DOI

Iriawati Iriawati,

Safira Vitasasti,

Fatimah Nur Azmi Rahmadian

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(7), P. e0304335 - e0304335

Published: July 3, 2024

Inflammation is an immune system response that identifies and eliminates foreign material. However, excessive persistent inflammation could disrupt the healing process. Plant-derived exosome-like nanoparticles (PDENs) are a promising candidate for therapeutic application because they safe, biodegradable biocompatible. In this study, papaya PDENs were isolated by PEG6000-based method characterized dynamic light scattering (DLS), transmission Electron Microscopy (TEM), bicinchoninic acid (BCA) assay method, GC-MS analysis, total phenolic content (TPC) 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. For in vitro test, we conducted internalization toxicity assessment, determination of nitrite concentration, assessed expression inflammatory cytokine genes using qRT-PCR RAW 264.7 cells. vivo was induced caudal fin amputation followed analysis macrophage neutrophil migration zebrafish (Danio rerio) larvae. The result showed can be well optimized differential centrifugation with addition 30 ppm pectolyase, 15% PEG, 0.2 M NaCl, which exhibited cup-shaped spherical morphological structure average diameter 168.8±9.62 nm. storage stable aquabidest 25 mM trehalose solution at -20˚C until fourth week. TPC estimation all ages did not show significant change, while DPPH test change second major compounds contained Papaya 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP). internalized non-cytotoxic to Moreover, LPS-induced cells treated decrease NO production downregulation mRNA pro-inflammatory (IL-1B IL-6) upregulation anti-inflammatory gene (IL-10). addition, tests on inhibition cell migration. These findings suggest possesses properties.

Language: Английский

Citations

Chitooligosaccharide from Pacific White Shrimp Shell Chitosan Ameliorates Inflammation and Oxidative Stress via NF-κB, Erk1/2, Akt and Nrf2/HO-1 Pathways in LPS-Induced RAW264.7 Macrophage Cells DOI

Lalita Chotphruethipong, Pithi Chanvorachote,

Ratchaneekorn Reudhabibadh

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(14), P. 2740 - 2740

Published: July 19, 2023

Chitooligosaccharide (COS), found in both insects and marine sources, has several bioactivities, such as anti-inflammation antioxidant activities. However, the mechanism of shrimp shell COS on retardation inflammatory effects is limited. Therefore, aim this study to examine aforementioned activities LPS-activated RAW264.7 macrophage cells. significantly improved cell viability at level 500 µg/mL could reduce TNF-α, NO IL-6 generations cells (p < 0.05). Furthermore, ROS formation, NF-κB overactivation, phosphorylation Erk1/2 Akt Nrf2/HO-1 LPS-exposed These results indicate that manifests anti-inflammatory activity action via NF-κB, Erk1/2, signaling with an increasing relevance for disorders.

Language: Английский

Citations

Understanding aconite's anti-fibrotic effects in cardiac fibrosis DOI

Ziwei Xing,

Chao Yang,

Yaqian Feng

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 122, P. 155112 - 155112

Published: Sept. 22, 2023

Language: Английский

Citations

Synthesis, docking and biological evaluation of purine-5-N-isosteresas anti-inflammatory agents DOI

Ahmed M. M. El‐Saghier, Souhaila S. Enaili, Aly Abdou

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(25), P. 17785 - 17800

Published: Jan. 1, 2024

An operationally simple one-pot three-component and convenient synthesis method for a series of diverse purine analogues 5-amino-7-(substituted)-

Language: Английский

Citations

Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction: In Vitro and In Silico Studies DOI

Nazir Ahmad, Kaisun Nesa Lesa, Navista Sri Octa Ujiantari

et al.

Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 39

Published: May 21, 2024

Human cognition fundamentally depends on memory. Alzheimer's disease exhibits a strong correlation with decline in this factor. Phosphodiesterase-4 B (PDE4B) plays crucial role neurodegenerative disorders, and its inhibition is one of the promising approaches for memory enhancement. This study aimed to identify secondary metabolites white cabbage, coffee, red onion extracts their molecular interaction PDE4B by

Language: Английский

Citations

(–)-Syringaresinol attenuates ulcerative colitis by improving intestinal epithelial barrier function and inhibiting inflammatory responses DOI

Yunhe Liu,

Junzhe Wu,

Luying Tan

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 124, P. 155292 - 155292

Published: Dec. 23, 2023

Language: Английский

Citations