Ubiquitin E3 ligases assisted technologies in protein degradation: Sharing pathways in neurodegenerative disorders and cancer
Ageing Research Reviews,
Год журнала:
2024,
Номер
96, С. 102279 - 102279
Опубликована: Март 22, 2024
Язык: Английский
The cross talk of ubiquitination and chemotherapy tolerance in colorectal cancer
Journal of Cancer Research and Clinical Oncology,
Год журнала:
2024,
Номер
150(3)
Опубликована: Март 23, 2024
Abstract
Ubiquitination,
a
highly
adaptable
post-translational
modification,
plays
pivotal
role
in
maintaining
cellular
protein
homeostasis,
encompassing
cancer
chemoresistance-associated
proteins.
Recent
findings
have
indicated
potential
correlation
between
perturbations
the
ubiquitination
process
and
emergence
of
drug
resistance
CRC
cancer.
Consequently,
numerous
studies
spurred
advancement
compounds
specifically
designed
to
target
ubiquitinates,
offering
promising
prospects
for
therapy.
In
this
review,
we
highlight
enzymes
associated
with
chemoresistance
chemotherapy
via
Wnt/β-catenin
signaling
pathway,
epithelial–mesenchymal
transition
(EMT),
cell
cycle
perturbation.
addition,
summarize
application
small
that
treatment,
along
significance
targeting
as
therapies.
Язык: Английский
Targeting MDM2-p53 interaction in Glioblastoma: Transcriptomic analysis and Peptide-Based inhibition strategy
Bioorganic Chemistry,
Год журнала:
2024,
Номер
150, С. 107620 - 107620
Опубликована: Июль 8, 2024
Язык: Английский
Nuciferine blocks MIB2-mediated CARD6 polyubiquitination and degradation in the amelioration of high fructose-induced liver lipid accumulation
Food & Function,
Год журнала:
2023,
Номер
14(10), С. 4706 - 4721
Опубликована: Янв. 1, 2023
Dietary
alkaloid
nuciferine
isolated
from
the
leaves
of
Nelumbo
nucifera
can
ameliorate
dyslipidemia
and
liver
lipid
accumulation,
but
underlying
mechanism
remains
unclear.
Caspase
recruitment
domain
protein
family
member
6
(CARD6)
is
suggested
to
play
an
important
role
in
metabolic
diseases.
This
study
aimed
investigate
upstream
regulator
CARD6
high
fructose-induced
accumulation
whether
how
anti-lipid
effect
was
related
CARD6.
Herein,
we
found
that
fructose
decreased
expression
increased
ASK1
JNK1/2
phosphorylation
rat
livers
hepatocytes,
which
were
attenuated
by
nuciferine.
Furthermore,
after
transfection
with
HA-CARD6,
siRNA
MIB2
siRNA,
data
showed
overexpression
blocked
upregulation
as
well
hepatocytes.
reversed
amelioration
hepatocyte
accumulation.
Mechanistically,
upregulated
interacting
promoting
K48-linked
polyubiquitination
degradation
fructose-stimulated
hepatocytes
explored
immunoblotting,
immunofluorescence,
immunoprecipitation.
However,
downregulation
Notably,
reduced
thus
These
results
exhibited
a
protective
against
through
blocking
MIB2-mediated
degradation.
Язык: Английский
Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug prediction using virtual screening
Neuropeptides,
Год журнала:
2023,
Номер
102, С. 102383 - 102383
Опубликована: Сен. 15, 2023
Язык: Английский
Unveiling immunological and prognostic potential of FBXO2 in BC based on Pan-Cancer and Single cell analyses
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 19, 2024
Abstract
Background
Breast
cancer
(BC)
is
a
typical
females’
malignant
tumors.
Ubiquitin-proteasome
system
(UPS)
critical
pathway
for
pathogenesis
of
BC.
Activation
UPS
determined
by
SKP1–cullin
1–F-box
protein
(SCF)
E3
ligase
complexes.
F-Box
Protein
2
(FBXO2),
pivotal
member
F-box
proteins
family,
related
with
and
mitophagy.
FBXO2
have
attracted
increasing
attention
in
multiple
cancers.
The
relationship
between
many
cancers
still
unclear.
Therefore,
systematic
research
on
pan-cancer
very
important
the
development
drug
resistance
Method
Transcriptome
expression
data
33
types
were
acquired
from
Cancer
Genome
Atlas
(TCGA)
database.
Wilcoxon’s
test
was
performed
to
estimate
molecular
characteristic
FBOX2
human
pan-cancer.
To
confirmed
BC,
mendelian
randomization
(MR)
performed.
Kaplan–Meier
(KM)
curves
analyze
survival
features
FBXO2.
Additionally,
level
methylation
explored
based
test.
Single
cell
sequence
analyses
used
furtherly
importance
Finally,
underlying
mechanism
various
perspectives,
including
gene
function,
immune
checkpoint
tumor
microenvironment.
Result
Our
revealed
that
up-regulation
through
analyses.
It
first
found
be
downregulated
MR
caused
FXBO2
KM
indicated
Low
had
poor
overall
(OS)
recurrence
free
(DFS)
obviously
enriched
epithelial
cell.
unveiled
role
Conclusion
Comprehensive
analysis
unveiling
immunological
promising
potential
value
provided
new
insight
Язык: Английский
Deciphering the Molecular Mechanism of HSP90AB1 as a Potential Heat Shock Protein and Understanding the Role of Alkaloids in the Therapeutic Suppression of Glioblastomas (GBMs)
Опубликована: Сен. 8, 2023
Heat
shock
proteins
(HSPs)
is
the
family
of
evolutionary
classes
protein
and
are
known
to
be
highly
conserved
plays
an
intricate
role
in
functioning
cells.
To
date,
very
few
studies
available
regarding
their
as
therapeutic
targets
glioblastomas.
With
this
study,
we
have
tried
identify
potential
HSPs
that
can
targeted
GBMs.
We
used
literature
survey
predict
post
differentially
expressed
gene
identification.
understand
molecular
mechanism
these
were
performed
functional
enrichment
analysis
comprising
biological
process,
cellular
components,
functions
was.
Mutational
was
then
carried
out
determine
most
ideal
HSP
for
targeting.
HSP90AB1
determined
target
further
analysis.
Alkaloids
which
a
class
natural
compounds
against
HSP90AB1.
Molecular
docking
how
interacting
with
different
alkaloids.
Finally,
binding
affinities
complexes
checked
identified
chelerythrine
cepharanthine
promising
inhibitors
glioblastoma.
These
findings
could
potentially
able
explain
option
Язык: Английский