Waste-to-resource: Extraction and transformation of aquatic biomaterials for regenerative medicine
Huaqi Cao,
Yuanjin Zeng,
Xueyu Yuan
и другие.
Biomaterials Advances,
Год журнала:
2024,
Номер
166, С. 214023 - 214023
Опубликована: Сен. 1, 2024
Язык: Английский
Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
280, С. 135572 - 135572
Опубликована: Сен. 11, 2024
Язык: Английский
Incorporation of Capecitabine Into Extended Chain of N‐Acylated Chitosan Carrier
Advances in Polymer Technology,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Enhancing
the
hydrophobicity
of
chitosan
through
acylation
enables
encapsulation
water‐insoluble
drugs
within
polymeric
carrier
cores.
In
this
study,
hydrophobically
modified
was
synthesized
by
reacting
low‐molecular‐weight
with
acyl
chloride
(C18–C24)
using
an
agitation
method
under
mild
conditions.
The
structure
acylated
analyzed
FTIR
and
1
H‐NMR
spectroscopy.
degree
substitution
(DS)
varied
between
56%
69%
for
different
long‐chain
N‐acylated
chitosan,
N‐stearoyl
(ChC18)
exhibiting
highest
DS.
incorporation
capecitabine
(CAP)
into
extended
increased
particle
size
decreased
zeta
potential.
N‐lignoceroyl
(ChC24)
exhibited
potential
value
−27
mV
0.2
mg
CAP,
indicating
that
most
group
stable
in
suspension.
Transmission
electron
microscope
images
revealed
all
particles
were
spherical,
sizes
ranging
from
100
to
200
nm,
existed
as
stand‐alone
entities,
excellent
stability
loading
CAP
but
did
not
alter
shape,
except
ChC24,
which
agglomeration.
SEM
individual
arrangement
CAP‐ChC18
made
it
more
than
other
chitosan.
contrast,
formation
clusters
CAP‐ChC24
can
be
attributed
strong
hydrophobic
interactions.
X‐ray
photoelectron
spectroscopy
results
show
there
is
no
nitrogen
atom
ChC18,
means
oriented
inward
bound
stearoyl
via
van
der
Waals
forces.
At
drug
weight‐to‐carrier
ratios,
efficiency
(EE)
varying
lengths
ranged
85%
97%.
(DL)
capacity
EE
amount
increased.
However,
length
significantly
affect
DL
EE,
even
when
carrier‐to‐drug
ratio
consistently
maintained.
Sustained
release
observed
CAP‐loaded
a
significant
influence
chain
on
Consequently,
possesses
enormous
delivery
system
CAP.
Язык: Английский
Development and Characterization of Tannic Acid‐Modified PVA‐κCarrageenan Gel for Sustained Release of Lidocaine
ChemistrySelect,
Год журнала:
2024,
Номер
9(37)
Опубликована: Сен. 27, 2024
Abstract
PVA‐κcarrageenan
(κCar)
gel
is
widely
used
in
the
pharmaceutical
field
for
transdermal
drug
delivery,
enhancing
stability
and
bioavailability.
This
study
aims
to
modify
PVA‐κCar
by
introducing
tannic
acid.
Lidocaine
was
as
a
model
incorporation
into
novel
gel.
The
matrix
mixed
with
acid
prior
freeze–
thaw
cycle
create
composite.
physicochemical
features
of
this
were
evaluated
using
FTIR,
XRD,
thermal
analysis,
SEM.
presence
has
reduced
from
84
around
70
°C.
content
acid‐modified
34.6%
(A)
52.1%
(B).
addition
substantially
increased
viscosity.
Cytotoxicity
analysis
showed
that
did
not
affect
viability
HCT
colon
cancer
cells.
encapsulation
efficiency
lidocaine
13
±
0.2%
12
0.5%
(B),
while
loading
0.96
0.01
0.91
0.02
In
vitro
release
modified
exhibited
sustained
mechanism
phosphate‐buffered
saline
solution.
These
findings
indicate
possesses
advantageous
characteristics
carrier.
Язык: Английский