Journal of cancer research updates,
Год журнала:
2024,
Номер
13, С. 85 - 99
Опубликована: Дек. 31, 2024
Objective:
The
study
aimed
to
identify
key
trends
in
modern
oncology
by
analysing
developments
and
innovations
early
cancer
diagnosis
treatment
methods.
Using
a
comparative
analysis
of
scientific
healthcare
systems
Albania,
Bulgaria,
Kyrgyzstan,
Uzbekistan,
the
examined
innovative
diagnostic
approaches
such
as
liquid
biopsy,
biomarker
discovery,
genetic
testing,
advanced
imaging
techniques,
artificial
intelligence
algorithms.
Methods:
For
treatment,
it
highlighted
immunotherapy,
personalised
medicine,
cellular,
targeted,
combination
therapies,
well
development
radiopharmaceuticals
3D
modelling
for
surgical
planning.
Results:
Key
findings
revealed
that
lack
economic
support
research
is
primary
barrier
innovation
all
four
countries.
benefiting
from
European
Union
membership,
demonstrated
highest
potential
advancing
due
its
stronger
scientific,
technical,
regulatory,
social
indicators.
In
contrast,
Albania's
transition
economy
Kyrgyzstan’s
geographical
challenges
significantly
hinder
progress.
underline
need
enhanced
investment,
international
cooperation,
regulatory
address
disparities
foster
implementation
practices
globally.
Conclusion:
This
regional
provides
insights
into
how
tailored
can
bridge
gap
between
low-
high-income
countries
care.
nowadays,
the
photoacoustic
imaging
is
in
mainstream
of
cancer
theranostics.
In
this
study
nanoparticles
with
previously
proven
properties,
i.e.
glucose-ethylenediamine
carbon
dots
(GE-NPs),
were
tested
for
therapy.
nanoparticle
biocompatibility
was
analyzed
cell
toxicity
and
neurotoxicity
experiments
ex
vivo.
Biochemical
parameters
animal
vivo
after
intramuscular
implantation
Lewis
Lung
carcinoma
cells
into
C57/Black
mouse
line.
GE-NPs
at
concentrations
0.1–1.0
mg/ml
did
not
change
extracellular
level,
exocytotic
transporter-mediated
release,
as
well
initial
rate
uptake
accumulation
L-[14C]glutamate
isolated
rat
brain
nerve
terminals.
GE-NP-treated
mice
had
evidence
probable
protection
liver
attenuating
systemic
consequences
tumor
growth,
evidenced
by
normalization
serum
aspartate
aminotransferase
(ASAT),
lactate
dehydrogenase
(LDH)
levels,
compared
to
vehicle-dosed
tumor-bearing
animals.
According
hematological
analysis,
treatment
caused
an
increase
red
blood
hematocrit
up
healthy
control
levels.
When
a
combination
(1
mg/ml)
injected
irradiated
laser
beam,
it
leads
survival
more
than
30%
GE-NPs-treated
non-irradiated
mice,
decrease
growth
cancerous
tumor.
The
observed
therapeutic
effect
can
be
related
photoacoustically-induced
destruction
significantly
enhanced
presence
incorporated
GE-NPs,
because
laser-induced
localized
heating
skin
has
exceeded
2
°C.
efficiency
therapy
using
biocompatible
demonstrated.
Biocompatible
own
multimodal
potential
theranostics,
including
both
therapy,
applying
different
irradiation
conditions.
International Journal of Materials Research (formerly Zeitschrift fuer Metallkunde),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Abstract
Carbon
dots
are
regarded
as
a
brand
new
class
of
nanostructures
in
the
carbonaceous
family
that
have
piqued
curiosity
researchers
wide
range
bio
applications.
This
work
focuses
on
synthesis
and
characterization
carbon
dots,
well
their
latent
fingerprint
detection
antibacterial/antifungal
capabilities.
Highly
luminous
were
prepared
by
optimizing
simple
hydrothermal
carbonization
settings
at
180
°C
for
12
h
using
lemon
juice
raw
precursor.
The
resulting
product
was
examined
Fourier
transform
infrared
spectroscopy,
scanning
electron
microscopy,
energy
dispersive
X-ray
analysis,
diffractometery,
ultraviolet–visible
spectrophotometer.
as-prepared
found
to
be
extremely
bright
when
excited
under
ultraviolet
light
(
λ
=
365
nm).
presence
oxygen
functionalities
surface
revealed
spectrocopy.
diffraction
pattern
confirmed
amorphous
structure
with
an
average
size
7
nm
determined
Scherrer
equation.
morphology
analysis
exhibited
aggregated
form
irregular
spherical
shapes.
chemical
examination
validated
elemental
makeup
juice-based
dots.
fingerprints
yielded
positive
results.
In
addition,
obtained
displayed
antifungal
antibacterial
activity
against
tested
pathogenic
fungal
bacterial
strains.
Asia Pacific Allergy,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Allergic
reactions
to
general
anesthetics,
though
rare,
can
lead
severe
complications.
Genetic
predisposition
and
prior
allergic
history
are
key
risk
factors,
but
the
exact
mechanisms
remain
under
investigation.
Effective
preventive
measures,
such
as
pretesting
alternative
drug
selection,
essential
minimizing
risks.
The
study
aims
review
factors
processes
underlying
development
of
anesthetics.
As
part
study,
a
literature
that
contained
data
on
patients
undergoing
anesthesia
was
analyzed
identify
cases
their
most
probable
causes.
Available
genetic
previous
status
patients,
which
may
affect
developing
an
reaction,
were
addressed.
results
showed
during
is
infrequent
phenomenon,
varying
severity
(from
skin
manifestations
anaphylaxis)
occur.
analysis
identified
patient
significantly
increase
allergies.
also
include
both
IgE-dependent
IgE-independent
pathways,
requires
comprehensive
approach
diagnosis.
Furthermore,
determined
several
occurred
due
lack
including
sensitivity
anesthetic
use
drugs
for
at
high
reactions.
findings
highlight
importance
collaboration
among
anesthetists,
allergists,
surgeons
reduce
allergy
ensure
maximum
safety.
obtained
impact
new
protocols
managing
improving
preoperative
diagnostic
methods
patients.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 13, 2024
Abstract
Water-soluble
fluorescent
N-doped
carbon
quantum
dots
(N-CQDs)
were
hydrothermally
prepared
through
a
green
synthesis
route
using
castor
seeds
as
single
precursor
and
hydrothermal
method.
Several
experimental
techniques
have
been
used
to
characterize
synthesized
N-CQDs
confirm
their
structure
verify
applicability
in
cell
imaging
pH
sensing.
The
found
are
characterized
by
amorphous
nature
with
spherical
shape
an
average
particle
size
of
6.57
nm
revealed
from
XRD
TEM
measurements.
FTIR
results
reveal
the
presence
carboxylic
hydroxyl
functional
groups
on
surface
CQDs,
which
was
also
confirmed
XPS
analysis.
fluorescence
characterization
showed
blue
emission
excitation
dependence
good
photostability.
It
that
optimal
wavelengths
(λ
Ex
=
360)
Em
432)
nm,
respectively.
yield
(QY)
about
9.6%
at
optimum
wavelength
360
nm.
Moreover,
intensity
linear
values
ranges
3.5
−
7.5
8
12
well
high
sensitivity
for
slight
changes
values.
According
these
results,
two
sensors
created
based
acidic
basic
media.
obtained
zeta
potential
-21.86
mV
thus
excellent
stability
water.
derived
antimicrobial
activity
exhibits
low
cytotoxicity
WI-13
cells
IC
50
394.4
±
13.8
µg/mL.
this
study
demonstrated
can
be
sensing
materials.
On
other
hand,
they
promising
applications
imaging,
thermo-sensing
optoelectronics.
Journal of the Chinese Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 12, 2025
Abstract
In
the
emerging
era
of
infectious
diseases,
antimicrobials
are
widely
applied
against
pathogenic
microbes
(i.e.,
bacteria,
fungus,
or
virus)
to
avoid
global
mortality.
Nonetheless,
quite
a
few
microbiome
adopted
genetic
mutations
over
extended
period
and
fostered
sustainable
resistance
towards
existing
newer
antibiotics.
Carbon
dots
(CDs)
carbon‐based
nanomaterials,
unveiled
their
potential
as
antifungal,
antibacterial,
antiviral
agents
resembled
with
ease
synthesis,
reduced
toxicity,
smart
functionalization,
high
aqueous
dispersibility,
auspicious
biocompatibility.
This
review
has
emphasized
discussion
corroborated
types
CDs
numerous
properties
tailored
biofunctionalization.
Further
article
was
featured
antiviral,
bioimaging,
biosensing,
anticancer
responsiveness
(in
vivo
in
vitro
mode)
followed
by
biocompatibility,
toxicity
assessments,
challenges,
future
prospectives.
