Fe₃O₄-Based Nanospheres with High Photothermal Conversion Efficiency for Dual-Effect and Mild Biofilm Eradication against Periodontitis

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Periodontitis, a chronic inflammatory oral disease resulting from plaque biofilms, affects about 743 million individuals worldwide. However, the efficacy of current treatments is hampered by challenges in delivering antibiotics to recalcitrant biofilms and bacterial resistance, thereby impeding successful treatment infectious diseases. To address issues, an antibacterial photothermal material was designed, comprising spherical structure zinc oxide (ZnO) wrapped with triiron tetraoxide (Fe3O4). The outer layer adsorbed epsilon-polylysine (EPL) electrostatic action, ultimately leading fabrication Fe3O4/ZnO/EPL nanoparticles (FZE NPs). Fe3O4 core endowed efficient properties, facilitating dispersion dense which dramatically promoted adsorption penetration ZnO EPL into effectively kill bacteria vitro enhanced sterilization ability. Additionally, upon dissolution aqueous media, acts as positively charged antimicrobial peptide that adsorbs onto surface negatively membranes, modulating responses. In order ascertain FZE NPs, investigation conducted their effects against periodontitis-associated pathogen Porphyromonas gingivalis (P. gingivalis) vitro. Furthermore, antiperiodontitis potential NPs evaluated Sprague-Dawley (SD) rats ligamentous periodontitis. addition, toxicity evaluations indicated had acceptable biosafety profile vivo. summary, nanospheres NPs) represent promising therapeutic strategy for

Язык: Английский

---

Beyond the Swipe: A Review of Photocatalytic Antimicrobial Biocompatible Touchscreen Technology

Applied Materials Today, Год журнала: 2025, Номер 44, С. 102697 - 102697

Опубликована: Март 30, 2025

Язык: Английский

---

Melanin as a Photothermal Agent in Antimicrobial Systems

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8975 - 8975

Опубликована: Авг. 18, 2024

Bacterial infection is one of the most problematic issues for human health and resistance bacteria to traditional antibiotics a matter huge concern. Therefore, research focusing on development new strategies efficiently kill these microorganisms. Recently, melanin starting be investigated this purpose. Indeed, very versatile material presents outstanding photothermal properties, already studied therapy, which can useful light-induced eradication bacteria. In review, we present antibacterial applications based effect, both single action its combination with other systems. Melanin, also thanks biocompatibility ease functionalization, has been demonstrated easily applicable as an antimicrobial agent, especially treatment local infections.

Язык: Английский

---

Stimuli-responsive and targeted nanomaterials: Revolutionizing the treatment of bacterial infections

Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 495 - 523

Опубликована: Ноя. 29, 2024

Язык: Английский

---

An exploration of the ocular mysteries linking nanoparticles to the patho-therapeutic effects against keratitis

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 6, 2025

Microbial keratitis, a sight-threatening corneal infection, remains significant global health concern. Conventional therapies using antimicrobial agents often suffers from limitations such as poor drug penetration, side effects, and occurrence of resistance, with prognosis. Novel treatment techniques, their unique properties targeted delivery capabilities, offers promising solution to overcome these challenges. This review delves into timely update the state-of-the-art advance therapeutics for keratitis treatment. The diverse microbial origins including viral, bacterial, fungal infections, exploring complex pathogenic mechanisms, followed by resistance mechanisms in pathogens are reviewed briefly. Importantly, emerging therapeutic techniques piezodynamic therapy, photothermal photodynamic nanoenzyme metal ion therapy summarized this showcasing potential traditional treatments. challenges future directions nanotechnology-based approaches discussed, focusing on safety, targeting strategies, combination therapies. aims inspire researchers revolutionize accelerate development functional materials different

Язык: Английский

---

Simple Method for Controlling Gold Nanocluster Size in Mesoporous Silica: SBA-11

Molecules, Год журнала: 2025, Номер 30(9), С. 2035 - 2035

Опубликована: Май 2, 2025

Mesoporous silica containing Au nanoclusters has been widely used in various fields owing to its desirable properties and functionality. This work introduces a facile method control the size of within hosts. was achieved by applying reducing gas at controlled temperature obtain narrow or broad cluster distribution inside host. The their hosts were characterized through X-ray diffraction, high-resolution transmission electron microscopy, energy-dispersive spectroscopy, ultraviolet-visible N2 sorption analysis, photoelectron spectroscopy. average 1.3 nm narrow-distribution sample. In comparison, wide-distribution sample exhibited two populations: 1–2 pores 5–30 outside pores. Methylene blue (M.B.) photocatalysis conducted under direct sunlight evaluate catalytic activity these materials. Sample 1–Au–SBA-11, clusters averaging nm, substantial M.B. degradation 90 min—half time required 2–Au–SBA-11 Such different ranges have potential applications across diverse fields.

Язык: Английский

---

3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

Three-dimensional (3D) printing technology has revolutionized the design and fabrication of bone scaffolds, offering precise customizable solutions for tissue engineering. In this study, we developed polycaprolactone (PCL) scaffolds that incorporated gold plasmonic blackbodies (AuPBs) to harness photothermal properties temperature-controlled regeneration. The AuPB-PCL demonstrated enhanced mechanical strength, a tunable thermal response under near-infrared (NIR) laser irradiation, improved osteogenic potential. Photothermal stimulation effectively modulated cellular responses, promoting osteoblast proliferation, alkaline phosphatase (ALP) activity, mineralization. Notably, mild hyperthermia (39-41 °C) induced by irradiation optimized osteogenesis, while excessive temperatures (≥42.5 impaired function due mitochondrial stress oxidative damage. These findings highlight potential controlled regeneration, promising strategy precise, completely noninvasive repair.

Язык: Английский

---

Photocatalytic effect of gold-zinc oxide composite nanostructures for the selective and controlled killing of antibiotic-resistant bacteria and the removal of resistant bacterial biofilms from the body

Nano Convergence, Год журнала: 2025, Номер 12(1)

Опубликована: Май 14, 2025

Abstract Infections involving antibiotic-resistant bacteria have become a major problem. Pathogenic use mechanisms such as drug target bypass, modification, and biofilm formation to evade treatment. To respond these problems, antibacterial research using metal oxide nanoparticles is currently active. Nanoparticles treat bacterial infections through reactive oxygen species generation or ion release. However, their application has faced problems related human compatibility, they react non-specifically, targeting both mammalian cells. In addition, ZnO show low activity against Gram-negative bacteria. Thus, the demand for substances with enhanced specificity improved efficacy increasing. We bound gold surface of nanoparticles, enabling photocatalytic photothermal actions visible light irradiation. improve specificity, Concanavalin A (Con A), lectin that can specifically membrane lipopolysaccharides, was conjugated nanoparticles. showed Con A-conjugated Au/ZnO (Au/ZnO-Con A) exhibit effects under white light, enhancing ability, increased anti-biofilm abilities were confirmed. The developed particles potential alleviate antibiotic resistance in skin infection model, presenting new platform treating infections. Graphical

Язык: Английский

---

Low-Power NIR-Triggered Photothermal Inactivation of Pseudomonas aeruginosa with Polypyrrole Nanoparticles

Polymers, Год журнала: 2025, Номер 17(11), С. 1442 - 1442

Опубликована: Май 23, 2025

Conducting polymer (CP) nanoparticles have emerged as innovative materials for biomedical applications, particularly due to their safe interaction with biological systems. This study focuses on the synthesis, morphological, and spectroscopic characterization of polypyrrole (PPy-NPs) photoactivatable agents under near-infrared (NIR) radiation inactivation pathogenic bacteria. We successfully synthesized uniform (~180 nm) strong absorption in NIR region. A comprehensive was performed using electron microscopy, dynamic light scattering, X-ray diffraction, UV–Vis infrared spectroscopy. The microbiological evaluation focused elucidating mechanism Pseudomonas aeruginosa, through oxidative stress induction, metabolic activity alteration, cell membrane disruption. Our results highlight significant potential PPy-NPs targeted microorganisms, underscoring promising applications antimicrobial surface coatings.

Язык: Английский

---

Visible Light-Driven Photocatalysis and Antibacterial Performance of a Cu-TiO₂ Nanocomposite

ACS Omega, Год журнала: 2024, Номер 9(47), С. 47122 - 47134

Опубликована: Ноя. 11, 2024

A Cu-TiO

Язык: Английский

---