Cancers, Год журнала: 2024, Номер 16(23), С. 4008 - 4008

Опубликована: Ноя. 29, 2024

Background/Objective: Colorectal cancer (CRC) is one of the most common cancers worldwide. Increasing scientific evidence supports idea that gut microbiota dysbiosis accompanies colorectal tumorigenesis, and these changes could be causative. Implementing analysis in clinical practice limited by sample type, sequencing platform taxonomic classification. This article aims to address limitations, providing new insights into associated with CRC pathogenesis implementing its analyses personalized medicine. Methods: To aim, we evaluate differences bacterial composition 130 paired tumor non-tumor adjacent tissues from a cohort patients Biobank University Navarra, Spain. The V3–V4 region 16S rRNA gene was amplified, sequenced using MinION platform, taxonomically classified NCBI database. Results: our knowledge, this first study report an increased relative abundance Streptococcus periodonticum decreased Corynebacterium CRC. Genera such as Fusobacterium, Leptotrichia showed higher abundances than tissues, previously described literature. Specifically, identified levels Fusobacterium animalis, nucleatum, polymorphum S. tissues. In contrast, genera Bacteroides lower There were also at level between locations. Conclusions: These results, consistent previous studies, further support hypothesis contribute progression, F. nucleatum animalis proposed key pathogenic taxa. Overall, results better understanding CRC-associated microbiota, addressing critical barriers implementation

Язык: Английский