New Insights into Mucosa-Associated Microbiota in Paired Tumor and Non-Tumor Adjacent Mucosal Tissues in Colorectal Cancer Patients DOI Open Access
Adriana González, Asier Fullaondo, David Navarro

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(23), P. 4008 - 4008

Published: Nov. 29, 2024

Background/Objective: Colorectal cancer (CRC) is one of the most common cancers worldwide. Increasing scientific evidence supports idea that gut microbiota dysbiosis accompanies colorectal tumorigenesis, and these changes could be causative. Implementing analysis in clinical practice limited by sample type, sequencing platform taxonomic classification. This article aims to address limitations, providing new insights into associated with CRC pathogenesis implementing its analyses personalized medicine. Methods: To aim, we evaluate differences bacterial composition 130 paired tumor non-tumor adjacent tissues from a cohort patients Biobank University Navarra, Spain. The V3–V4 region 16S rRNA gene was amplified, sequenced using MinION platform, taxonomically classified NCBI database. Results: our knowledge, this first study report an increased relative abundance Streptococcus periodonticum decreased Corynebacterium CRC. Genera such as Fusobacterium, Leptotrichia showed higher abundances than tissues, previously described literature. Specifically, identified levels Fusobacterium animalis, nucleatum, polymorphum S. tissues. In contrast, genera Bacteroides lower There were also at level between locations. Conclusions: These results, consistent previous studies, further support hypothesis contribute progression, F. nucleatum animalis proposed key pathogenic taxa. Overall, results better understanding CRC-associated microbiota, addressing critical barriers implementation

Language: Английский

Advances in polymer-centric nanomedicines for theranostic cancer treatment DOI

Anindita Bag,

Rahul Maheshwari

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106105 - 106105

Published: Aug. 28, 2024

Language: Английский

Citations

0

Personalised medicine based on host genetics and microbiota applied to colorectal cancer DOI
Adriana González, Iker Badiola, Asier Fullaondo

et al.

Advances in genetics, Journal Year: 2024, Volume and Issue: unknown, P. 411 - 485

Published: Jan. 1, 2024

Language: Английский

Citations

0

Host genetics-associated mechanisms in colorectal cancer DOI
Adriana González, Asier Fullaondo,

Adrián Odriozola

et al.

Advances in genetics, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 122

Published: Jan. 1, 2024

Language: Английский

Citations

0

Host genetics and microbiota data analysis in colorectal cancer research DOI

Adriana González,

Asier Fullaondo,

Adrián Odriozola

et al.

Advances in genetics, Journal Year: 2024, Volume and Issue: unknown, P. 31 - 81

Published: Jan. 1, 2024

Language: Английский

Citations

0

Conclusion: emerging frontiers and prospects in colorectal cancer drug resistance DOI
Zodwa Dlamini, Botle Precious Damane, Georgios Lolas

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 425 - 429

Published: Nov. 8, 2024

Language: Английский

Citations

0

New Insights into Mucosa-Associated Microbiota in Paired Tumor and Non-Tumor Adjacent Mucosal Tissues in Colorectal Cancer Patients DOI Open Access
Adriana González, Asier Fullaondo, David Navarro

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(23), P. 4008 - 4008

Published: Nov. 29, 2024

Background/Objective: Colorectal cancer (CRC) is one of the most common cancers worldwide. Increasing scientific evidence supports idea that gut microbiota dysbiosis accompanies colorectal tumorigenesis, and these changes could be causative. Implementing analysis in clinical practice limited by sample type, sequencing platform taxonomic classification. This article aims to address limitations, providing new insights into associated with CRC pathogenesis implementing its analyses personalized medicine. Methods: To aim, we evaluate differences bacterial composition 130 paired tumor non-tumor adjacent tissues from a cohort patients Biobank University Navarra, Spain. The V3–V4 region 16S rRNA gene was amplified, sequenced using MinION platform, taxonomically classified NCBI database. Results: our knowledge, this first study report an increased relative abundance Streptococcus periodonticum decreased Corynebacterium CRC. Genera such as Fusobacterium, Leptotrichia showed higher abundances than tissues, previously described literature. Specifically, identified levels Fusobacterium animalis, nucleatum, polymorphum S. tissues. In contrast, genera Bacteroides lower There were also at level between locations. Conclusions: These results, consistent previous studies, further support hypothesis contribute progression, F. nucleatum animalis proposed key pathogenic taxa. Overall, results better understanding CRC-associated microbiota, addressing critical barriers implementation

Language: Английский

Citations

0