In Vivo Electrochemical Biosensing Technologies for Neurochemicals: Recent Advances in Electrochemical Sensors and Devices

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

In vivo electrochemical sensing of neurotransmitters, neuromodulators, and metabolites plays a critical role in real-time monitoring various physiological or psychological processes the central nervous system. Currently, advanced biosensors technologies have been emerging as prominent ways to meet surging requirements neurotransmitters neuromodulators ranging from single cells brain slices, even entire brain. This review introduces fundamental working principles summarizes achievements biosensing including voltammetry, amperometry, potentiometry, field-effect transistor (FET), organic (OECT). According elaborate feature technology, versatile strategies devoted solve issues associated with neurochemicals under an intricate environment. Voltammetry is universal technique investigate complex matrices which could realize miniaturization electrodes, while amperometry serves well-suited approach offering high temporal resolution favorable for fast oxidation–reduction kinetics neurochemicals. Potentiometry realizes quantitative analysis by recording potential difference reduced invasiveness compatibility. FET OECT serve amplification higher sensitivity than traditional technologies. Furthermore, we point out current shortcomings address challenges perspectives

Язык: Английский

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A Comparative Study of the Electronic Transport and Gas-Sensitive Properties of Graphene+, T-graphene, Net-graphene, and Biphenylene-Based Two-Dimensional Devices

ACS Sensors, Год журнала: 2023, Номер 8(9), С. 3510 - 3519

Опубликована: Авг. 10, 2023

The electronic transport properties of the four carbon isomers: graphene+, T-graphene, net-graphene, and biphenylene, as well gas-sensing to nitrogen-based gas molecules including NO2, NO, NH3 molecules, are systematically studied comparatively analyzed by combining density functional theory with nonequilibrium Green's function. isomers metallic, especially graphene+ being a Dirac metal due two cones present at Fermi energy level. two-dimensional devices based on these exhibit good conduction in order biphenylene > T-graphene net-graphene. More interestingly, net-graphene-based biphenylene-based demonstrate significant anisotropic properties. sensors above structures all have selectivity sensitivity NO2 molecule, among which T-graphene-based most prominent maximum ΔI value 39.98 μA, only three-fifths original. In addition, graphene+-based also sensitive NO molecule values 29.42 25.63 respectively. However, physically adsorbed for molecule. By adsorption energy, charge transfer, electron localization functions, molecular projection self-consistent Hamiltonian states, mechanisms behind can be clearly explained. This work shows potential detection toxic NO2.

Язык: Английский

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A miniaturized biosensor for rapid detection of tetracycline based on a graphene field-effect transistor with an aptamer modified gate

Talanta, Год журнала: 2024, Номер 271, С. 125702 - 125702

Опубликована: Янв. 20, 2024

Язык: Английский

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AlC3 monolayer: Highly responsive and selective gas sensing material for SF6 decomposed gases (SOF2, SO2F2 and SO2)

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 700, С. 134724 - 134724

Опубликована: Июль 4, 2024

Язык: Английский

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Chemical engineering innovations in nanoparticle-based biosensors for enhanced detection of biological molecules

Chemical Engineering Journal, Год журнала: 2025, Номер 507, С. 160081 - 160081

Опубликована: Янв. 31, 2025

Язык: Английский

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Triple microenvironment modulation of zeolite imidazolate framework (ZIF) nanocages for boosting dopamine electrocatalysis

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 654, С. 1 - 12

Опубликована: Окт. 9, 2023

Язык: Английский

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Highly Efficient Dopamine Sensing with a Carbon Nanotube-Encapsulated Metal Chalcogenide Nanostructure

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(5), С. 4814 - 4823

Опубликована: Фев. 27, 2024

Carbon nanotube-encapsulated nickel selenide composite nanostructures were used as nonenzymatic electrochemical sensors for dopamine detection. These synthesized through a simple, one-step, and environmentally friendly chemical vapor deposition method, wherein the CNTs formed in situ from pyrolysis of carbon-rich metallo-organic precursor. The composition morphology these hybrid NiSe2-filled carbon confirmed by powder X-ray diffraction, Raman, photoelectron spectroscopy, high-resolution transmission electron microscopy images. Electrochemical tests demonstrated that as-synthesized exhibited outstanding electrocatalytic performance toward oxidation, with high sensitivity 19.62 μA μM–1 cm–2, low detection limit, broad linear range 5 nM–640 μM, selectivity. synergistic effects enhanced activity along conductivity nanotubes led to efficiency nanostructured composites. selectivity this could be exploited develop selective, sensitive detect quantify human tear samples reliability. This sensor, hence, paves way discoveries development cost stability, which can noninvasive peripheral bodily fluids.

Язык: Английский

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Paper Sensor Modified with MoS₂ for Detection of Dopamine Using a Machine-Intelligent Web App Interface

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(36), С. 43060 - 43074

Опубликована: Авг. 29, 2023

The sensing behavior of a MoS2-functionalized paper sensor towards dopamine was explored through combinatorial approach theoretical analysis, subsequent experimental validation, and machine-learning-driven predictive modeling the measured electrochemical outputs. suitability chosen 2D material for efficient detection confirmed using density functional theory. physisorption along with electrostatic interaction due to incorporation on MoS2 unraveled under purview theoretically estimated noncovalent charge difference plot. Löwdin population analysis elucidates alteration in oxidation potential dopamine, as observed experiments. responses developed spiked serum samples showed an average accuracy more than 96% limit 10 nM. Furthermore, implementation machine-intelligent interactive web app interface improved resolution platform significantly enhanced nearly 99%.

Язык: Английский

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Solution-Gated Thin Film Transistor Biosensor-Based SnO₂ Amorphous Film for Label-Free Detection of Epithelial Cell Adhesion Molecules

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Epithelial cell adhesion molecule (EpCAM) was considered to be an important marker of multiple tumors, and its high expression is closely related the early diagnosis treatment tumors. At present, metal oxide semiconductors have become a key component biosensor bioelectronics technology. Tin shows great potential for development because nontoxic, nonpolluting, low price, excellent electrical properties. In this study, novel SnO2 solution-gated thin film transistor (SGTFT) specific detection EpCAM successfully developed using prepared by sol-gel method as channel material. By selecting optimal thickness 100 nm material, transconductance value (gm) reached 1432 μS, threshold voltage (Vth) remained stable at 0.288 V. order achieve qualitative quantitative EpCAM, films were subjected chemical fix aptamer. Through recognition between aptamer gate changes triggered regulate current device. FE-SEM, EIS, XPS, performance tests employed track measure modification process. Based on optimizations described above, SGTFT exhibited sensitivity (14.6 mV·dec-1), limit (LOD) down 24.4 pg/mL, calibration curves in range 0.02 ng/mL-500 ng/mL sensing. The SnO2-SGTFT anticipated provide new highly sensitive platform health monitoring disease diagnosis.

Язык: Английский

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Graphene Photoelectrochemical Transistor for Dual‐Directional Signal‐on Biosensing

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Abstract Recent research has demonstrated the potential of photogating in regulating characteristics photoelectrochemical transistors. Here it is reported graphene transistor (GPECT) with dual‐directional signal‐on biosensing as exemplified by channel gated p/n‐type metal–organic frameworks (MOFs) upon light illumination toward aptasensing. Due to shift Dirac point induced MOFs, operation mutually verifiable dual readout could be achieved. For aptasensing, assistance biocatalytic precipitation reaction, such a device validated for highly sensitive detection thrombin limits low 5.2 and 0.1 f m , respectively. This study demonstrates not only general protocol GPECTs but also unique novel optoelectronics.

Язык: Английский

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