Analytical Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
Chemically
synthesized
gold
nanoantennas
possess
easy
processability,
low
cost,
and
suitability
for
large-area
fabrication,
making
them
advantageous
surface-enhanced
infrared
(SEIRA)
biosensing.
Nevertheless,
current
face
challenges
with
limited
enhancement
of
biomolecular
signals
that
hinder
their
practical
applications.
Here,
we
demonstrate
the
coupling
rate
between
antennas
molecules
critically
impacts
molecular
based
on
temporal
coupled
mode
theory.
To
improve
this
rate,
nanonails
sharp
tips,
significantly
amplifying
localized
electric
fields
antenna
resonance
modes.
Modulating
nanonail
aspect
ratio
allows
us
to
tailor
frequencies
match
vibrational
frequencies.
Additionally,
introduced
specific
aptamers
surfaces
through
solution
exchange
methods
control
antenna-molecule
distances.
These
combined
strategies
enabled
noninvasive,
label-free
detection
high
sensitivity
biomarker
cortisol.
Experiments
revealed
3
orders
magnitude
in
cortisol
levels
upon
increasing
efficiency,
achieving
a
limit
0.1
ng/mL,
notably
lower
than
normal
concentration
human
saliva
(0.398
ng/mL).
In
addition
demonstrating
novel
strategy
detection,
study
provides
viable
approach
future
applications
disease
diagnosis
health
monitoring.
Journal of The Electrochemical Society,
Год журнала:
2025,
Номер
172(3), С. 037504 - 037504
Опубликована: Фев. 21, 2025
Cortisol
is
a
key
factor
in
developmental
and
behavioural
research,
measured
widely
blood,
urine,
saliva.
Electrochemical
sensing
has
emerged
as
reliable
technique
the
development
of
point-of-care
devices
for
detecting
cortisol.
Here,
ZnO/Graphene
coated
graphite
was
used
electrode
detection
The
performance
tested
presence
cortisol
using
electrochemical
techniques
impact
scan
rate,
concentration,
cycle
numbers,
linear
range,
limit
reported.
fabricated
ZnO/Graphene/PGE
demonstrated
excellent
detection,
exhibiting
response
over
wide
concentration
range
10.874
to
173.981
mg
ml
−1
low
6.162
μg
.
Additionally,
sensor
displayed
high
stability
60
days,
with
good
repeatability
reproducibility.
This
shows
that
nanocomposite
can
be
non-enzymatic
providing
more
effective
sensing.
With
the
goal
of
impacting
patient
quality
life
and
outcomes,
sensor
science
offers
significant
potential
to
revolutionize
healthcare
by
providing
advances
in
detection
molecular
biomarkers
for
personalized
clinical
technologies.
The
community
has
achieved
technical
advancements
that
can
impact
diagnostics,
health
monitoring,
disease
treatment;
however,
many
innovations
remain
confined
laboratory,
failing
bridge
translational
gap
between
research
real-world
applications.
This
perspective
presents
a
new
direction
community,
where
development
centers
on
needs
experiences
primary
beneficiaries:
patients.
We
provide
guidelines
resources
researchers
engage
with
patients
early
continuously
throughout
process
inform
specifications
better
align
technologies
needs,
improving
their
adoption
impact.
also
present
examples
implementing
patient-centered
approach
planning
engagement
research.
In
design
impactful
sensors
patients,
must
expand
focus
beyond
embrace
approach,
which
will
likely
lead
opportunities
collaboration
evolution
community.
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
21(4)
Опубликована: Апрель 1, 2025
Abstract
INTRODUCTION
This
study
investigates
whether
midlife
cortisol
levels
predict
Alzheimer's
disease
(AD)
biomarker
burden
15
years
later,
with
particular
attention
to
sex
differences
and
menopausal
status.
METHODS
We
analyzed
data
from
305
cognitively
unimpaired
Framingham
Heart
Study
participants
(48.5%
female;
mean
age:
39.6
±
8.1
years).
Serum
was
categorized
into
tertiles,
amyloid
([
11
C]PiB)
tau
18
F]Flortaucipir)
positron
emission
tomography
(PET)
imaging
conducted
later.
performed
multivariable
regression
analyses
adjusted
for
confounders
including,
apolipoprotein
E4
(APOE4)
RESULTS
Elevated
correlated
increased
deposition,
specifically
in
post‐menopausal
women,
predominantly
posterior
cingulate,
precuneus,
frontal‐lateral
regions
(
p
<
0.05).
No
significant
associations
were
observed
or
males.
DISCUSSION
These
findings
reveal
women
high
are
at
risk
of
AD.
Results
highlight
the
importance
identifying
early
factors
when
biomarkers
detectable
but
cognitive
impairment
is
absent.
Highlights
High
linked
deposition
women.
Cortisol
showed
no
association
pathology.
Post‐menopausal
hormone
changes
may
amplify
cortisol's
effects
on
amyloid.
Noncommunicable
diseases
(NCDs)
associated
with
cardiovascular,
neurological,
and
gastrointestinal
disorders
remain
a
leading
cause
of
global
mortality,
sounding
the
alarm
for
urgent
need
better
diagnostic
therapeutic
solutions.
Wearable
implantable
biointegrated
electronics
offer
groundbreaking
solution,
combining
real-time,
high-resolution
monitoring
innovative
treatment
capabilities
tailored
to
specific
organ
functions.
In
this
comprehensive
review,
we
focus
on
affecting
brain,
heart,
organs,
bladder,
adrenal
gland,
along
their
physiological
parameters.
Additionally,
provide
an
overview
characteristics
these
parameters
explore
potential
bioelectronic
devices
in
situ
sensing
applications
highlight
recent
advancements
deployment
across
organs.
Finally,
analyze
current
challenges
prospects
implementing
closed-loop
feedback
control
systems
integrated
sensor-therapy
applications.
By
emphasizing
organ-specific
advocating
systems,
review
highlights
future
bioelectronics
address
needs
serves
as
guide
researchers
navigating
interdisciplinary
fields
diagnostics,
therapeutics,
personalized
medicine.
The
neurologic
effects
of
long-COVID
are
a
therapeutic
challenge.
This
article
discusses
the
immunologic
manifestations
and
proposes
non-androgenic,
synthetic
analog
dehydroepiandrosterone
(DHEA),
bromo-epi-androsterone
(BEA),
as
candidate
for
clinical
trials
this
exigent
collection
conditions.
Moreover,
because
there
is
an
association
between
Alzheimer’s
disease,
evaluation
BEA
in
may
serve
proxy
its
effect
on
neuroinflammatory
biomarkers
disease
that
shared
with
long-COVID.
