Analytical Methods,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
In
this
study,
a
sensitive
sandwich
electrochemical
immunosensor
for
the
detection
of
cancer
marker
antigen
125
(CA125)
was
developed
using
polypyrrole
(PPy)
microspheres
amplifying
sensing
signal.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(31), С. 12838 - 12845
Опубликована: Июль 25, 2024
MicroRNA
(miRNA)
detection
is
a
critical
aspect
of
disease
diagnosis,
and
recent
studies
indicate
that
miRNA-622
could
be
potential
target
for
lung
cancer.
Herein,
Cu
single
atoms
were
anchored
on
graphitic
carbon
nitride
(Cu
SAs@CN)
as
coreaction
accelerator
applied
in
luminol-H
Abstract
Exploring
novel
electrochemiluminescence
(ECL)
co‐reaction
accelerators
to
construct
ultrasensitive
sensing
systems
is
a
prominent
focus
for
developing
advanced
ECL
sensors.
However,
challenges
still
remain
in
finding
highly
efficient
and
understanding
their
promoting
mechanisms.
In
this
paper,
ZIF‐67@MXene
nanosheet
composites,
with
conductive
in‐plane
structure
confined‐stable
pore/channel,
are
designed
act
as
high‐efficient
achieve
significant
enhancement
the
luminol‐H
2
O
based
system.
Mechanism
investigation
suggests
that
hydroxyl
radicals
(·OH)
singlet
oxygen
(
1
)
can
be
selectively
preferentially
generated
on
due
stable
absorption
of
·OH
,
leading
remarkable
efficiency
luminol
(830%).
Finally,
by
designing
plasmonic
NH
‐MIL‐88@Pd
nanozyme,
an
“on‐off”
switch
immunosensor
constructed
detection
prostate‐specific
antigen
(PSA).
Based
multiple
signal
amplification
effect,
linear
range
PSA
expanded
three
orders
magnitude.
The
limit
also
improved
from
1.44
×
10
−11
9.1
−13
g
mL
−1
.
This
work
proposes
effective
method
preparation
provides
new
strategy
sensitive
cancer
markers.
Analytical Methods,
Год журнала:
2024,
Номер
16(29), С. 4938 - 4950
Опубликована: Янв. 1, 2024
Nanohybrid
based
non-invasive
biosensing
platforms
are
emerging
as
promising
alternatives
to
detect
biomarkers
in
complex
and
diverse
bio-fluids
toward
ultrasensitive
point-of-care
diagnostics.