Talanta, Год журнала: 2024, Номер 286, С. 127475 - 127475
Опубликована: Дек. 26, 2024
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 3, 2025
Язык: Английский
Процитировано
0
Methods and Protocols, Год журнала: 2024, Номер 7(5), С. 73 - 73
Опубликована: Сен. 13, 2024
The article aims to outline the potential of treating malignant skin cancer with microneedles covered polymer layers containing a photosensitizer-protoporphyrin IX disodium salt (PPIX). usefulness stereolithography (SLA), which is form 3D-printing technology, for preparation microneedle system protoporphyrin was demonstrated. SLA method allowed pyramid-shaped be printed that were three different 0.1% PPIX hydrogels based on sodium alginate, xanthan, and poloxamer. Rheological tests microscopic analysis performed. Microneedles coated two poloxamer-based hydrogel subjected release in Franz diffusion cells. profile initially increased then remained relatively constant. amount substance released after four-hour test cells 0.2569 ± 0.0683 mg/cm
Язык: Английский
Процитировано
2
ACS Applied Polymer Materials, Год журнала: 2024, Номер 6(20), С. 12362 - 12381
Опубликована: Окт. 15, 2024
Mechanical metamaterials have garnered significant attention due to their extraordinary mechanical properties derived from structural design. This displays huge potential for emerging material applications. Although hydrogels present challenges in the fabrication of intrinsic high water content, inclusion is desirable because unique responsive properties. distinctive responsiveness and characteristics opens up exciting possibilities smart applications fields such as biomedical engineering, soft robotics, sensors. In past five years, advancements hydrogel techniques additive manufacturing multimaterial approaches enabled design more complex customizable ranging macro- nanostructures. review offers recent insights into materials metamaterials, highlighting development diverse by harnessing characteristics. It discusses various metamaterial characteristics, including negative hydration expansion, auxetic behavior, geometric transformation, programmable properties, while also addressing current charting future prospects field.
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2024, Номер 30(1), С. 15 - 15
Опубликована: Дек. 24, 2024
Therapeutic drug monitoring (TDM) is pivotal for optimizing dosage regimens in individual patients, particularly drugs with a narrow therapeutic index. Surface-enhanced Raman spectroscopy (SERS) has shown great potential TDM due to high sensitivity, non-destructive analysis, specific fingerprint spectrum, low sample consumption, simple operation, and ongoing costs. Due the rapid development of SERS TDM, review focusing on analytical method presented better understand trends. This examines latest advancements substrates their applications highlighting innovations substrate design that enhance detection sensitivity selectivity. We discuss challenges faced by such as signal reproducibility matrix interference from complex biological samples, explore solutions like digital colloid-enhanced spectroscopy, enrichment strategies, microfluidic SERS, tandem instrument technologies, machine learning-enabled SERS. These address limitations traditional improve efficiency TDM. Finally, conclusions perspectives future research directions are presented. The integration emerging technologies presents transformative approach significantly personalized medicine patient outcomes.
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 327, С. 125393 - 125393
Опубликована: Ноя. 3, 2024
Язык: Английский
Процитировано
0
Biosensors, Год журнала: 2024, Номер 14(12), С. 564 - 564
Опубликована: Ноя. 21, 2024
This review examines recent advances in surface-enhanced Raman spectroscopy (SERS) for urinary metabolite analysis, focusing on the development and application of noble metal nanohybrids. We explore diverse range hybrid materials, including carbon-based, metal–organic-framework (MOF), silicon-based, semiconductor, polymer-based systems, which have significantly improved SERS performance detecting key biomarkers. The principles underlying enhancement these nanohybrids are discussed, elucidating both electromagnetic chemical mechanisms. analyze various fabrication methods that enable precise control over nanostructure morphology, composition, surface chemistry. critically evaluates analytical different systems specific metabolites, considering factors such as sensitivity, selectivity, stability. address challenges associated with SERS-based sample preparation, matrix effects, data interpretation. Innovative solutions, integration microfluidic devices machine learning algorithms spectral highlighted. potential advanced platforms point-of-care diagnostics personalized medicine is along future perspectives wearable sensors multi-modal analysis techniques. comprehensive overview provides insights into current state directions technology detection, emphasizing its to revolutionize non-invasive health monitoring disease diagnosis.
Язык: Английский
Процитировано
0
ACS Materials Au, Год журнала: 2024, Номер 5(1), С. 115 - 140
Опубликована: Ноя. 28, 2024
The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged prominent area focus in biomedical research because its ability to deliver wide range biomolecules, vaccines, medicines, other substances through skin. Microneedles (MNs) form microchannels by disrupting skin's structure, which compromises function, facilitating easy penetration drugs into These devices enhance administration many therapeutic skin, enhancing their stability. Transcutaneous medications using microneedle patch offers advantages over conventional drug methods. containing active can be stimulated different internal external factors result regulated release substances. To achieve efficient desired location, it is necessary consider design needles with appropriate optimized characteristics. choice materials for developing manufacturing these vital determining pharmacodynamics pharmacokinetics delivery. This article provides most recent update overview numerous systems that utilize activators stimulate components from microneedles. Further, discusses utilized producing microneedles strategies important managing drugs. An explanation commonly employed fabrication techniques applications electronics, particularly integrated systems, discussed. successfully implement clinical settings, essential comprehensively assess several factors, biocompatibility, stability, safety, production cost. Finally, an in-depth review criteria difficulties potential future direction delivering monitoring diseases explored.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1571 - 1571
Опубликована: Дек. 9, 2024
Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due their excellent biocompatibility, high drug-loading capacity, tunable drug-release properties. This review systematically examines matrix materials fabrication methods HMN systems, highlighting advancements in natural synthetic polymers, explores applications treating conditions such as wound healing, hair loss, cardiovascular diseases, cancer. Furthermore, potential HMNs disease diagnostics is discussed. The identifies key challenges, including limited mechanical strength, efficiency, lack standardization, while proposing strategies overcome these issues. With integration intelligent design enhanced control over dosage safety, are poised revolutionize expand personalized medicine.
Язык: Английский
Процитировано
0