CrystEngComm,
Год журнала:
2020,
Номер
22(43), С. 7341 - 7349
Опубликована: Янв. 1, 2020
CSD
data
mining
and
energy
calculations
show
that
coformer
self-interactions
might
significantly
contribute
to
the
packing
stabilization
of
cocrystals.
Crystal Growth & Design,
Год журнала:
2020,
Номер
20(10), С. 6796 - 6803
Опубликована: Авг. 21, 2020
The
antibiotic
ciprofloxacin
(CIP)
zwitterion
has
been
cocrystallized
via
slurry
and/or
ball-milling
with
carvacrol
(CAR)
and
thymol
(THY),
also
known
to
exert
antimicrobial
activity,
the
aim
of
improving
antibacterial
activity
ciprofloxacin.
In
case
CAR,
1:4
cocrystal
CIP·CAR4
appears
be
most
stable
phase,
where
intermediate
phases
CIP·CAR3
CIP·CAR2
have
isolated
by
stepwise
loss
CAR.
THY,
1:2
CIP·THY2
is
stable,
while
CIP·THY4
easily
loses
THY
yield
bisadduct.
All
cocrystals
were
structurally
characterized
single
crystal
or
powder
diffraction:
in
both
sheets
CIP
molecules
are
intercalated
layers
CAR
respectively,
that
can
released
upon
heating
as
followed
DSC,
TGA
variable
temperature
XRPD.
Preliminary
experiments
provide
encouraging
evidence
enhanced
against
Escherichia
coli
(ATCC
25922)
respect
pure
well
physical
mixtures
thymol.
Crystal Growth & Design,
Год журнала:
2022,
Номер
22(7), С. 4260 - 4267
Опубликована: Июнь 1, 2022
Mechanochemistry
has
become
a
sustainable
and
attractive
cost-effective
synthetic
technique,
largely
used
within
the
frame
of
crystal
engineering.
Cocrystals,
namely,
crystalline
compounds
made
different
chemical
entities
same
structure,
are
typically
synthesized
in
bulk
via
mechanochemistry;
however,
whereas
macroscopic
aspects
grinding
becoming
clear,
fundamental
principles
that
underlie
mechanochemical
cocrystallization
at
microscopic
level
remain
poorly
understood.
Time-resolved
situ
(TRIS)
monitoring
approaches
have
opened
door
to
exceptional
detail
regarding
reactions.
We
here
report
clear
example
between
two
solid
coformers
proceeds
through
formation
metastable
low
melting
binary
eutectic
phase.
The
overall
process
been
monitored
by
time-resolved
synchrotron
X-ray
powder
diffraction
with
customized
ball
milling
setup,
currently
available
μSpot
beamline
BESSY-II,
Helmholtz-Zentrum
Berlin.
system
phase
were
further
characterized
DSC,
HSM,
VT-XRPD.
Chemical Communications,
Год журнала:
2020,
Номер
56(38), С. 5127 - 5130
Опубликована: Янв. 1, 2020
We
present
a
simple
way
of
estimating
the
entropy
cost
solvate
formation
in
crystals.
The
penalty
making
solvates
can
be
as
low
<1
kJ
mol-1
or
high
>9
and
is
entirely
dependent
on
nature
liquid
component
temperature
formation.
A
link
found
between
higher
likelihood
for
solvent
to
make
solvates.
CrystEngComm,
Год журнала:
2020,
Номер
22(43), С. 7341 - 7349
Опубликована: Янв. 1, 2020
CSD
data
mining
and
energy
calculations
show
that
coformer
self-interactions
might
significantly
contribute
to
the
packing
stabilization
of
cocrystals.