CrystEngComm,
Journal Year:
2020,
Volume and Issue:
22(43), P. 7341 - 7349
Published: Jan. 1, 2020
CSD
data
mining
and
energy
calculations
show
that
coformer
self-interactions
might
significantly
contribute
to
the
packing
stabilization
of
cocrystals.
Crystal Growth & Design,
Journal Year:
2022,
Volume and Issue:
22(7), P. 4260 - 4267
Published: June 1, 2022
Mechanochemistry
has
become
a
sustainable
and
attractive
cost-effective
synthetic
technique,
largely
used
within
the
frame
of
crystal
engineering.
Cocrystals,
namely,
crystalline
compounds
made
different
chemical
entities
same
structure,
are
typically
synthesized
in
bulk
via
mechanochemistry;
however,
whereas
macroscopic
aspects
grinding
becoming
clear,
fundamental
principles
that
underlie
mechanochemical
cocrystallization
at
microscopic
level
remain
poorly
understood.
Time-resolved
situ
(TRIS)
monitoring
approaches
have
opened
door
to
exceptional
detail
regarding
reactions.
We
here
report
clear
example
between
two
solid
coformers
proceeds
through
formation
metastable
low
melting
binary
eutectic
phase.
The
overall
process
been
monitored
by
time-resolved
synchrotron
X-ray
powder
diffraction
with
customized
ball
milling
setup,
currently
available
μSpot
beamline
BESSY-II,
Helmholtz-Zentrum
Berlin.
system
phase
were
further
characterized
DSC,
HSM,
VT-XRPD.
Chemical Communications,
Journal Year:
2020,
Volume and Issue:
56(38), P. 5127 - 5130
Published: Jan. 1, 2020
We
present
a
simple
way
of
estimating
the
entropy
cost
solvate
formation
in
crystals.
The
penalty
making
solvates
can
be
as
low
<1
kJ
mol-1
or
high
>9
and
is
entirely
dependent
on
nature
liquid
component
temperature
formation.
A
link
found
between
higher
likelihood
for
solvent
to
make
solvates.
CrystEngComm,
Journal Year:
2020,
Volume and Issue:
22(43), P. 7341 - 7349
Published: Jan. 1, 2020
CSD
data
mining
and
energy
calculations
show
that
coformer
self-interactions
might
significantly
contribute
to
the
packing
stabilization
of
cocrystals.