Science China Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 22, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216544 - 216544
Опубликована: Фев. 24, 2025
Язык: Английский
Процитировано
1
Journal of the American Chemical Society, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 20, 2024
Treatment of glioblastoma (GBM) remains challenging due to the presence blood-brain barrier (BBB) and tumor heterogeneity. Herein, Au nanosheets (AuNSs) functionalized with RGD peptides small interfering RNA (siRNA), referred as AuNSs-RGD-C≡C-siRNA (ARCR), are prepared achieve multimodal therapy for GBM. The AuNSs a large modifiable surface area, intriguing photothermal conversion efficiency (50.26%), remarkable stability (44 cycles over 7 h) created using well-designed amphiphilic surfactant. Furthermore, alkynyl groups assembled onto within 1 min, enabling strong covalent binding siRNA thereby avoiding interference from biological thiols. Owing lipophilicity surfactant targeting property RGD, ARCR effectively passes through BBB accumulates in GBM regions, allowing near-infrared photoacoustic imaging-guided photothermal/gene therapy. This work proposes facile strategy construct theranostic Au-based materials, highlighting potential multifunctional nanoagents
Язык: Английский
Процитировано
4
Microorganisms, Год журнала: 2025, Номер 13(4), С. 708 - 708
Опубликована: Март 21, 2025
The rise of multi-drug-resistant (MDR) bacteria poses a severe global threat to public health, necessitating the development innovative therapeutic strategies overcome these challenges. Copper-based nanomaterials have emerged as promising agents due their intrinsic antibacterial properties, cost-effectiveness, and adaptability for multifunctional approaches. These materials exhibit exceptional potential in advanced therapies, including chemodynamic therapy (CDT), photothermal (PTT), photodynamic (PDT). Their unique physicochemical such controlled ion release, reactive oxygen species (ROS) generation, tunable catalytic activity, enable them target MDR effectively while minimizing off-target effects. This paper systematically reviews mechanisms through which Cu-based enhance efficiency emphasizes specific performance field. Key factors influencing properties—such electronic interactions, characteristics, size effects, ligand single-atom doping, geometric configurations—are analyzed depth. By uncovering copper-based nanomaterials, this work aims inspire approaches that improve patient outcomes, reduce burden bacterial infections, health initiatives.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101541 - 101541
Опубликована: Фев. 1, 2025
Blockade of heat shock protein 90 (HSP90) expression in multimodal synergistic therapy has a great prospect for cancer treatment. Nanomaterials combined with bioinformatic analysis provides accurate guidance the design anti-HSP90 nanomedicines. Herein, NIR-II-responsive nanoplatform was developed under bioinformatics guided to effectly inhibit HSP90 enhanced mild-photothermal chemotherapy without any notable tissue damage. The nanoplatforms were assembled from gold nanobipyramids (GNBs) curcumin (Cur) via hydrophobic-hydrophobic interactions and hydrogen bonds. On basis drug discovery network pharmacology, we found that Cur impressive capability analyzed its therapeutic mechanism against NSCLC. Under irradiation NIR-II light, obtained GNBs-Cur blocked HPS90 inhibited related antiapoptotic pathways, thus enhancing mild PTT GNBs 1064 nm laser irradiation. Meanwhile, served as chemotherapeutic agents induce apoptosis tumor cells. In vivo photoacoustic imaging-guided, achieved effective elimination through systemic toxicity. Overall, this work new modality paradigm potential NSCLC treatment on therapies.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Gold nanoclusters emitting in the second biological window (NIR-II-AuNCs) have gained significant interest for their potential deep-tissue bioimaging and biosensing applications due to partial transparency reduced autofluorescence of tissues this spectral range. However, limited understanding how environment affects luminescent properties might hinder use biosensing. In study, we investigated emission NIR-II-AuNCs when interacting internalizing into live cells including macrophages, fibroblasts, cancer cell lines, revealing substantial alterations luminescence. A systematic comparison between control vitro experiments concluded that disruption surface ligands is main factor responsible these alterations. within cellular environments may also be influenced by other interactions, aggregation or complexation with proteins. Furthermore, corroborated spectroscopic modifications at vivo level, providing additional evidence environmental sensitivity NIR-II-AuNCs. The results obtained study contribute a deeper luminescence mechanisms living are crucial optimization as reliable tools imaging diagnostics.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 20, 2025
Abstract Intrinsically theranostic metal nanoclusters are rare unless the stabilizing ligands exhibit therapeutic properties. A promising class of quasi‐molecular, near‐infrared (NIR) emitting, cytotoxic gold nanoclusters, coined as AXE (Au eXcitable and Eliminable) stabilized through terminal thioester groups on fluorinated, crosslinked polymers, is presented for simultaneous bioimaging & therapy. Nano Variable Temperature‐Electrospray ionization mass spectrometry analysis these aqueous stable revealed 5 to 7 core atoms, with SAXS measurement confirming average size be under 1 nm, consistent theoretical maximum few atom planar clusters. Despite its small size, exhibits a remarkable Stoke shift ≈470 nm emission range spanning 700 1100 nm. Fluorination notably enhanced quantum yield by up twofold, attributed charge transfer from fluorinated monomer core, indicated Löwdin distribution analysis. The nanocluster demonstrated dose‐dependent pro‐apoptotic effects cancer cells while sparing normal at lower concentrations. Preclinical evaluation in breast tumor model confirmed anticancer efficacy, intravenous intraperitoneal administrations significantly inhibiting growth controlling lung metastasis, surpassing clinical standard, doxorubicin.
Язык: Английский
Процитировано
0
Chemical & Biomedical Imaging, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Aggregation-induced emission (AIE) materials, due to their unique ability significantly enhance optical in aggregated states, have demonstrated vast potential immunology, particularly early disease diagnosis and immunotherapy. AIE materials can serve as highly efficient fluorescent probes for biomarker detection, providing critical insights diagnosis. Additionally, they act cancer vaccines, enhancing the effectiveness of immunotherapy through photodynamic therapy, photothermal or activation immune cells. This review highlights applications focusing on recent advancements diagnostics while also discussing challenges face directions future development.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Май 22, 2025
The second near-infrared (NIR-II) window (1000-1700 nm) offers advantages in biomedical applications such as deeper tissue penetration and superior imaging contrast. Despite this potential, existing NIR-II probes are limited by biocompatibility concerns, photobleaching, poor photostability, issues that constrain their clinical utility. This study introduces Janus-type gold nanodiscs having an asymmetrically integrated hierarchical polyaniline (PANI) structure, optimized for use multifunctional agents photothermal therapy multimodal imaging. By shifting the localized surface plasmon resonance of nanodiscs─the foundation Janus structure─from NIR-I to NIR-II, developed AuPANI achieve remarkable deep-tissue photoacoustic imaging, up 15 mm, while also enabling highly sensitive positron emission tomography through stable radiolabeling. exhibit photostability notable efficacy photoacoustic-guided under 1064 nm irradiation. positions a versatile platform theranostics, addressing limitations current advancing potential precise effective cancer treatment.
Язык: Английский
Процитировано
0
Nanotechnology Reviews, Год журнала: 2024, Номер 13(1)
Опубликована: Янв. 1, 2024
Abstract Gold nanoclusters (AuNCs), with sizes below 2 nm, have emerged as remarkable nanomaterials exhibiting unique optical, electronic, and chemical properties. Their ultra-small size imparts advantageous characteristics, including high surface area, tunable fluorescence, excellent biocompatibility, making AuNCs highly promising for diverse applications. This article explores recent advancements in leveraging to address critical challenges clean energy storage environmental remediation. For storage, boost the performance of Li-based batteries by facilitating rapid electron transfer kinetics limiting polysulfide shuttling. The review delves into mechanistic insights governing AuNC–hydrogen interactions, various synthetic approaches tailoring AuNCs, their emerging applications advanced electrodes, efficient catalysts, conductive additives enabling improved charge capabilities. Additionally, using plasmonic effects hot carrier generation induced shows tremendous potential photocatalytic water splitting hydrogen fuel production. applications, enable degradation persistent organic pollutants, heavy metal ion detection at part-per-trillion levels, solar-driven purification, relying on plasmon-enhanced processes. However, long-term ecological impacts remain unclear. study thus underscores need further toxicological assessments life cycle analyses promote sustainable AuNC-based technologies through responsible research innovation. Overall, it highlights versatile applicability addressing challenges.
Язык: Английский
Процитировано
0
Science China Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 22, 2024
Язык: Английский
Процитировано
0