Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease DOI Creative Commons

Yuan Yuan Wei,

Ting Ting Chen,

Da Wei Zhang

и другие.

Autophagy, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Microplastics (MPs) induce mitochondrial dysfunction and iron accumulation, contributing to macroautophagy/autophagy ferroptosis, which has increased susceptibility the exacerbation of chronic obstructive pulmonary disease (COPD); however, underlying mechanism remains unclear. We demonstrated that MPs intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis (ADF) vitro vivo. In lung tissues patients with COPD, concentrations MPs, especially polystyrene microplastics (PS-MPs), were significantly higher than control group, as detected pyrolysis gas chromatography mass spectrometry (Py-GCMS), accumulation. The exposure PS-MPs, 2 μm size, resulted their being deposited lungs model mice optical vivo imaging, observed bronchial epithelial cells traced GFP-labeled PS-MPs. There impairments accompanied reactive oxygen species (mito-ROS) overproduction levels lysosome biogenesis acidification pDHBE PS-MP stimulation, triggering occurrence ferritinophagy ADF triggered acute (AECOPD). Reestablishing via mitochondria-specific ROS scavenging or inhibition alleviated excessive ameliorated AECOPD induced Collectively, our data initially revealed exacerbate mito-ROS-mediated autophagy sheds light on further hazard assessments human respiratory health potential therapeutic agents for COPD.

Язык: Английский

Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease DOI
Yujie Shi,

Runyang Hong,

Zhencheng Fan

и другие.

Toxicology, Год журнала: 2025, Номер 511, С. 154067 - 154067

Опубликована: Янв. 25, 2025

Язык: Английский

Процитировано

2
Polystyrene nanoplastics trigger ferroptosis in Nrf2-deficient gut via ether phospholipid accumulation DOI Creative Commons

Boxuan Liang,

Xiyun Huang,

Zhiming Li

и другие.

Environment International, Год журнала: 2025, Номер 197, С. 109367 - 109367

Опубликована: Март 1, 2025

The widespread environmental presence of nanoplastics (NPs) raises significant concerns about their health impacts, particularly on the gastrointestinal system, as NPs are primarily ingested. While previous studies have linked NP-induced intestinal toxicity to oxidative stress and reactive oxygen species (ROS) accumulation, specific mechanisms cell death remain unclear. Here, we showed that environmentally relevant concentrations polystyrene (PS-NPs) induced ferroptosis, a form lipid peroxidation-driven death, in epithelial cells. Using epithelial-specific Nrf2-deficient mice (Nrf2fl/fl-VilCre+) human Caco-2 cells, demonstrated Nrf2, key regulator, play protective role against PS-NP-induced ferroptosis. PS-NP exposure disrupted ether phospholipid metabolism, leading accumulation polyunsaturated fatty acid-ether phospholipids heightened peroxidation intestines Nrf2fl/fl-VilCre+ mice. This increased susceptibility cells Additionally, high-fat diet further exacerbated this effect, suggesting individuals with reduced NRF2 activity poor dietary habits may be especially vulnerable damage. Our findings offered new insights into molecular underscored risks posed by exposure, populations compromised antioxidant defenses.

Язык: Английский

Процитировано

2
Size-Dependent Pulmonary Toxicity and Whole-Body Distribution of Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure DOI
Leijian Chen, Yu Liu, Huankai Li

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

The ubiquitous presence of micro/nanoplastics (MP/NP) in the atmosphere has raised significant concerns about their potential health risks through inhalation, yet effects natural respiratory exposure remain underexplored. This study addresses this critical knowledge void by utilizing a whole-body inhalation system to investigate distribution, accumulation, and pulmonary toxicity polystyrene MP/NP (1.5 × 105 particles/m3) male ICR mice (n = 16/group). Fluorescently labeled revealed highest particle accumulation lungs, followed bloodstream spleen, with minimal detection brain. Unsurprisingly, 80 nm nanoplastics displayed greater intertissue transport efficiency than 1 μm microplastics. Chronic both microplastics disrupted oxidative balance exacerbated stress within extracellular environment lungs. impaired antioxidant defenses intra- metabolism led inflammation, apoptosis, fibrosis. Intriguingly, induced more severe smaller counterparts, promoting epithelial-mesenchymal transition These findings underscore need for nuanced understanding size-dependent toxicities inhalable plastic particles highlight posed airborne MP/NP.

Язык: Английский

Процитировано

2
Hazards of microplastics on human health and its mitigation strategies DOI

Surya Radhakrishnan Ezhava,

Victor Lobo, Seema Prabhudev Rodge

и другие.

Toxicology and Environmental Health Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

1
An Overview on Microplastics Hazards to the Marine Ecosystem and Humans’ Health DOI Open Access
Asia Grattagliano,

Zaira Grattagliano,

Loredana Manfra

и другие.

Water, Год журнала: 2025, Номер 17(7), С. 916 - 916

Опубликована: Март 21, 2025

Microplastic contamination is rapidly becoming an increasingly worrying environmental problem and poses a real threat to marine ecosystems human health. The aim of this research was conduct traditional review the current state art regarding sources MPs in environment, including assessment their toxic effect on organisms transfer within food webs up humans. An extensive literature search (from 1 January 2024 15 February 2025) yielded total 1027 primary articles topic. This overview revealed that can be ingested by organisms, migrate through intestinal wall, spread other organs. They biomagnify along chain carriers chemicals pathogen agents. Exposure lead several risks, tissue damage, oxidative stress, changes immune-related gene expression, neurotoxicity, growth retardation, behavioural abnormalities. toxicity depends mainly particle size distribution composition/characteristics polymer. main routes exposure have been identified as ingestion (mainly seafood), inhalation, dermal exposure. There strong evidence seafood MPs, which pose potential risk study provides basis for assessing MPs’ health impacts.

Язык: Английский

Процитировано

1
Marine Micro(nano)plastics Toxicology: Knowledge Gaps and Perspectives DOI Creative Commons
Wen‐Xiong Wang

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138086 - 138086

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Microplastics and Nanoplastics Impair the Biophysical Function of Pulmonary Surfactant by Forming Heteroaggregates at the Alveolar–Capillary Interface DOI
Xiaojie Xu,

Ria A. Goros,

Zheng Dong

и другие.

Environmental Science & Technology, Год журнала: 2023, Номер 57(50), С. 21050 - 21060

Опубликована: Дек. 6, 2023

Microplastics (MPs) are ubiquitous environmental pollutants produced through the degradation of plastic products. Nanoplastics (NPs), commonly coexisting with MPs in environment, submicrometer debris incidentally from fragmentation MPs. We studied biophysical impacts MPs/NPs derived used commercial products on a natural pulmonary surfactant extracted calf lung lavage. It was found that comparison to lunch boxes made polypropylene or drinking water bottles poly(ethylene terephthalate), MP/NP foam packaging polystyrene showed highest adverse impact function surfactant. Accordingly, intranasal exposure also induced most serious proinflammatory responses and injury mice. Atomic force microscopy revealed NP particles were adsorbed air–water surface heteroaggregated film. These results indicate although formed NPs only make up small mass fraction, they likely play predominant role determining nano-bio interactions toxicity by forming heteroaggregates at alveolar–capillary interface. findings may provide novel insights into understanding health respiratory system.

Язык: Английский

Процитировано

21
Corncob-derived biodegradable packaging films: A sustainable solution for raspberry post-harvest preservation DOI
Sandeep Paudel, Srinivas Janaswamy

Food Chemistry, Год журнала: 2024, Номер 454, С. 139749 - 139749

Опубликована: Май 23, 2024

Язык: Английский

Процитировано

9
Impacts of micro and nanoplastics on human health DOI Creative Commons
Jayavel Sridhar,

Boopalakrishnan Govindaraju,

Johni Rexliene Michael

и другие.

Bulletin of the National Research Centre/Bulletin of the National Research Center, Год журнала: 2024, Номер 48(1)

Опубликована: Окт. 22, 2024

Abstract Background Plastics are the most flexible products developed with a wide range of applications. They have been incorporated into almost every aspect daily life due to their strength and low weight. However, widespread use inadequate waste management resulted in accumulation tiny plastic particles throughout environment. Main text Microplastics found oceans, rivers, sediments, sewers, soil, agricultural products, even table salts. Human beings affected by microplastics through food ingestion inhalation. Incorporated may accrue within body affect gastrointestinal, immune, endocrine, brain, respiratory systems. It also interferes functions major organs causes chromosomal abnormalities. Conclusion Addressing issue micro nanoplastics requires interdisciplinary research, sustainable solutions, improved The main focus this review is cover harmful effects impact on human health stress need for combating strategies.

Язык: Английский

Процитировано

9
Impact of microplastic intake via poultry products: Environmental toxicity and human health DOI Creative Commons
Prabhakar Sharma, V. K. Vidyarthi

Journal of Hazardous Materials Advances, Год журнала: 2024, Номер 14, С. 100426 - 100426

Опубликована: Апрель 12, 2024

In recent years, the escalating concerns surrounding pervasive presence of microplastics in environment had prompted a pressing need to evaluate their potential impacts on ecosystems and human health. This study investigates pathways implications microplastic intake through poultry product consumption by focusing environmental toxicity health risks. Through an integrated approach encompassing available experimental data literature synthesis, intricate mechanisms transfer from feed animal tissues are elucidated highlighting such contamination. An in-depth toxicological assessment evaluated risks associated with ingestion food emphasizing acute chronic effects well-being. emphasizes urgency implementing informed policy decisions sustainable practices mitigate posed contamination chain. The insights provided this serve as foundational basis for generating awareness effective measures aimed at safeguarding both integrity well-being threats pollution.

Язык: Английский

Процитировано

8