The progress and perspective of strategies to improve tumor penetration of nanomedicines

Chinese Chemical Letters, Год журнала: 2020, Номер 32(4), С. 1341 - 1347

Опубликована: Ноя. 3, 2020

Язык: Английский

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Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis

Journal of Controlled Release, Год журнала: 2020, Номер 327, С. 676 - 687

Опубликована: Сен. 11, 2020

Язык: Английский

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ATP Suppression by pH‐Activated Mitochondria‐Targeted Delivery of Nitric Oxide Nanoplatform for Drug Resistance Reversal and Metastasis Inhibition

Small, Год журнала: 2020, Номер 16(23)

Опубликована: Май 6, 2020

Abstract Mitochondria, which are important mediators for cancer initiation, growth, metastasis, and drug resistance, have been considered as a major target in therapy. Herein, an acid‐activated mitochondria‐targeted nanocarrier is constructed precise delivery of nitric oxide (NO) adenosine triphosphate (ATP) suppressor to amplify the therapeutic efficacy treatments. By combining α‐cyclodextrin (α‐CD) acid‐cleavable dimethylmaleic anhydride modified PEG conjugated mitochondria‐targeting peptide, shows prolonged blood circulation time enhanced cellular uptake together with selectively restoring capability under tumor extracellular pH (6.5). Such specific NO proves crucial inducing mitochondria dysfunction through facilitating mitochondrial membrane permeabilization downregulating ATP level, can inhibit P‐glycoprotein‐related bioactivities formation tumor‐derived microvesicles combat resistance metastasis. Therefore, this pioneering supposed be malignant opponent may provide insights diverse NO‐relevant

Язык: Английский

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Cell-penetrating peptides in protein mimicry and cancer therapeutics

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 180, С. 114044 - 114044

Опубликована: Ноя. 10, 2021

Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many drugs require specificity delivery to cancer cells, whilst sparing healthy tissue. Cell-penetrating peptides (CPPs), now well established as facilitators intracellular delivery, have recent years advanced incorporate target and thus possess great potential for targeted cargoes. Though none yet approved clinical use, this novel technology already entered trials. In review we present CPPs, discuss their classification, mechanisms cargo internalization highlight strategies conjugation moieties including incorporation into therapeutic proteins. As mainstay review, build tumor targeting CPP constructs through exploitation microenvironment use homing are discussed, acknowledging extensive contribution made by specific protein–protein interactions integral signaling pathways associated with cell survival progression. Finally, antibody/antigen conjugates roles immunotherapy diagnostics considered. summary, aims harness CPP-aided drug future therapies highlighting some most achievements selective drugs, cytostatic a range cells both vitro vivo.

Язык: Английский

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Recent advances and prospects in gemcitabine drug delivery systems

International Journal of Pharmaceutics, Год журнала: 2020, Номер 592, С. 120043 - 120043

Опубликована: Ноя. 3, 2020

Язык: Английский

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