Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
207, С. 115195 - 115195
Опубликована: Фев. 5, 2024
Enhanced
targeting
approaches
will
support
the
treatment
of
diseases
associated
with
dysfunctional
mitochondria,
which
play
critical
roles
in
energy
generation
and
cell
survival.
Obstacles
to
mitochondria-specific
include
presence
distinct
biological
barriers
need
pass
through
(or
avoid)
various
internalization
mechanisms.
A
range
studies
have
reported
design
mitochondrially-targeted
nanomedicines
that
navigate
complex
routes
required
influence
mitochondrial
function;
nonetheless,
a
significant
journey
lies
ahead
before
become
suitable
for
clinical
use.
Moving
swiftly
forward
require
safety
studies,
vivo
assays
confirming
effectiveness,
methodologies
validate
mitochondria-targeted
nanomedicines'
subcellular
location/activity.
From
nanomedicine
standpoint,
we
describe
involved
(from
administration
arrival
within
mitochondria),
features
influencing
rational
design,
techniques
used
identify/validate
successful
targeting.
Overall,
rationally-designed
mitochondria-targeted-based
hold
great
promise
precise
therapeutic
delivery.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(4), С. 2839 - 2891
Опубликована: Янв. 1, 2021
Supramolecular
cancer
nanotheranostics
have
shown
promising
potentials
in
early-stage
diagnosis
and
personal
therapy.
Herein,
we
summarize
the
progress
of
supramolecular
provide
guidance
for
designing
new
targeted
theranostic
agents.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Авг. 7, 2023
Cancer
remains
a
highly
lethal
disease
in
the
world.
Currently,
either
conventional
cancer
therapies
or
modern
immunotherapies
are
non-tumor-targeted
therapeutic
approaches
that
cannot
accurately
distinguish
malignant
cells
from
healthy
ones,
giving
rise
to
multiple
undesired
side
effects.
Recent
advances
nanotechnology,
accompanied
by
our
growing
understanding
of
biology
and
nano-bio
interactions,
have
led
development
series
nanocarriers,
which
aim
improve
efficacy
while
reducing
off-target
toxicity
encapsulated
anticancer
agents
through
tumor
tissue-,
cell-,
organelle-specific
targeting.
However,
vast
majority
nanocarriers
do
not
possess
hierarchical
targeting
capability,
their
indices
often
compromised
poor
accumulation,
inefficient
cellular
internalization,
inaccurate
subcellular
localization.
This
Review
outlines
current
prospective
strategies
design
organelle-targeted
nanomedicines,
highlights
latest
progress
technologies
can
dynamically
integrate
these
three
different
stages
static
maximize
outcomes.
Finally,
we
briefly
discuss
challenges
future
opportunities
for
clinical
translation
nanomedicines.
ACS Nano,
Год журнала:
2023,
Номер
17(10), С. 8935 - 8965
Опубликована: Май 1, 2023
Nitric
oxide
(NO),
a
gaseous
transmitter
extensively
present
in
the
human
body,
regulates
vascular
relaxation,
immune
response,
inflammation,
neurotransmission,
and
other
crucial
functions.
Nitrite
donors
have
been
used
clinically
to
treat
angina,
heart
failure,
pulmonary
hypertension,
erectile
dysfunction.
Based
on
NO's
vast
biological
functions,
it
further
can
tumors,
bacteria/biofilms
infections,
wound
healing,
eye
diseases,
osteoporosis.
However,
delivering
NO
is
challenging
due
uncontrolled
blood
circulation
release
half-life
of
under
five
seconds.
With
advanced
biotechnology
development
nanomedicine,
packaged
with
multifunctional
nanocarriers
by
physically
embedding
or
chemically
conjugating
reported
show
improved
therapeutic
efficacy
reduced
side
effects.
Herein,
we
review
discuss
recent
applications
nanomedicines,
their
mechanisms,
challenges
nanomedicines
for
future
scientific
studies
clinical
applications.
As
enables
inhibition
replication
DNA
RNA
infectious
microbes,
including
COVID-19
coronaviruses
malaria
parasites,
highlight
potential
antipandemic
efforts.
This
aims
provide
deep
insights
practical
hints
into
design
strategies
nanomedicines.
ACS Nano,
Год журнала:
2023,
Номер
17(7), С. 6731 - 6744
Опубликована: Март 22, 2023
Reactive
oxygen
species
(ROS)
generators
are
sparking
breakthroughs
in
sensitization
and
treatment
of
therapy-resistant
tumors,
yet
the
efficacy
is
drastically
compromised
by
limited
substrate
concentrations,
short
lifetimes
free
radicals,
restricted
oxidative
damage.
Herein,
a
flower-like
nanozyme
with
highly
permeable
leaflets
accommodating
catalytic
metal
sites
was
developed
to
address
challenges
boosting
product
accessibility.
In
formation
zeolite
imidazole
framework,
cobalt
ions
promoted
polymerization
deposition
polydopamine.
The
polymers
acted
as
stiffener
for
preventing
framework
collapse
maneuvering
pore
reopening
during
carbonization.
single-atom/cluster
porous
matrix
generated
peroxidase/oxidase-like
activities
high
efficiency
(Kcat/Km)
up
6
orders
magnitude
greater
than
that
conventional
nano-/biozymes.
Thereby,
robust
ROS
storm
induced
selective
catalysis
led
rapid
accumulation
damage
failure
antioxidant
antiapoptotic
defense
synchronization
drug-resistant
cancer
cells.
By
synergy
redox
homeostasis
disrupter
co-delivered,
significantly
antitumor
realized
vivo.
This
work
offers
route
kinetically
favorable
advancing
tumors.
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Abstract
Cancer
cells
typically
display
redox
imbalance
compared
with
normal
due
to
increased
metabolic
rate,
accumulated
mitochondrial
dysfunction,
elevated
cell
signaling,
and
accelerated
peroxisomal
activities.
This
may
regulate
gene
expression,
alter
protein
stability,
modulate
existing
cellular
programs,
resulting
in
inefficient
treatment
modalities.
Therapeutic
strategies
targeting
intra‐
or
extracellular
states
of
cancer
at
varying
state
progression
trigger
programmed
death
if
exceeded
a
certain
threshold,
enabling
therapeutic
selectivity
overcoming
resistance
radiotherapy
chemotherapy.
Nanotechnology
provides
new
opportunities
for
modulating
their
excellent
designability
high
reactivity.
Various
nanomaterials
are
widely
researched
enhance
highly
reactive
substances
(free
radicals)
production,
disrupt
the
endogenous
antioxidant
defense
systems,
both.
Here,
physiological
features
described
challenges
illustrated.
Then,
that
classified
elaborated
upon
based
on
ability
target
regulations.
Finally,
future
perspectives
this
field
proposed.
It
is
hoped
review
guidance
design
nanomaterials‐based
approaches
involving
therapy,
especially
cancers
resistant
chemotherapy,
etc.
