Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(41)
Опубликована: Авг. 26, 2022
Herein,
an
electroreductive
carboxylation
of
organic
carbon-halogen
bonds
(X=Br
and
Cl)
promoted
by
catalytic
amounts
naphthalene
as
mediator
is
reported.
This
transformation
proceeds
smoothly
under
mild
conditions
with
a
broad
substrate
scope
59
examples,
affording
the
valuable
versatile
carboxylic
acids
in
moderate
to
excellent
yields
without
need
costly
transition
metal,
wasted
stoichiometric
metal
reductants,
or
sacrificial
anodes.
Further
late-stage
carboxylations
natural
product
drug
derivatives
demonstrate
its
synthetic
utility.
Mechanistic
studies
confirmed
activation
via
single-electron
transfer
key
role
this
reaction.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(14), С. 7941 - 8002
Опубликована: Янв. 1, 2021
Electrochemistry
has
recently
gained
increased
attention
as
a
versatile
strategy
for
achieving
challenging
transformations
at
the
forefront
of
synthetic
organic
chemistry.
Electrochemistry's
unique
ability
to
generate
highly
reactive
radical
and
ion
intermediates
in
controlled
fashion
under
mild
conditions
inspired
development
number
new
electrochemical
methodologies
preparation
valuable
chemical
motifs.
Particularly,
recent
developments
electrosynthesis
have
featured
an
use
redox-active
electrocatalysts
further
enhance
control
over
selective
formation
downstream
reactivity
these
intermediates.
Furthermore,
electrocatalytic
mediators
enable
proceed
manner
that
is
mechanistically
distinct
from
purely
methods,
allowing
subversion
kinetic
thermodynamic
obstacles
encountered
conventional
synthesis.
This
review
highlights
key
innovations
within
past
decade
area
electrocatalysis,
with
emphasis
on
mechanisms
catalyst
design
principles
underpinning
advancements.
A
host
oxidative
reductive
are
discussed
grouped
according
classification
transformation
nature
electrocatalyst.
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 1875 - 1924
Опубликована: Авг. 6, 2021
Direct
photocatalyzed
hydrogen
atom
transfer
(d-HAT)
can
be
considered
a
method
of
choice
for
the
elaboration
aliphatic
C–H
bonds.
In
this
manifold,
photocatalyst
(PCHAT)
exploits
energy
photon
to
trigger
homolytic
cleavage
such
bonds
in
organic
compounds.
Selective
bond
may
achieved
by
judicious
abstractor
(key
parameters
are
electronic
character
and
molecular
structure),
as
well
reaction
additives.
Different
classes
PCsHAT
available,
including
aromatic
ketones,
xanthene
dyes
(Eosin
Y),
polyoxometalates,
uranyl
salts,
metal-oxo
porphyrin
tris(amino)cyclopropenium
radical
dication.
The
processes
(mainly
C–C
formation)
most
cases
carried
out
under
mild
conditions
with
help
visible
light.
aim
review
is
offer
comprehensive
survey
synthetic
applications
d-HAT.
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 2752 - 2906
Опубликована: Авг. 10, 2021
Photoinduced
chemical
transformations
have
received
in
recent
years
a
tremendous
amount
of
attention,
providing
plethora
opportunities
to
synthetic
organic
chemists.
However,
performing
photochemical
transformation
can
be
quite
challenge
because
various
issues
related
the
delivery
photons.
These
challenges
barred
widespread
adoption
steps
industry.
past
decade,
several
technological
innovations
led
more
reproducible,
selective,
and
scalable
photoinduced
reactions.
Herein,
we
provide
comprehensive
overview
these
exciting
advances,
including
flow
chemistry,
high-throughput
experimentation,
reactor
design
scale-up,
combination
photo-
electro-chemistry.
Chemical Reviews,
Год журнала:
2023,
Номер
123(8), С. 4237 - 4352
Опубликована: Янв. 24, 2023
The
emergence
of
modern
photocatalysis,
characterized
by
mildness
and
selectivity,
has
significantly
spurred
innovative
late-stage
C–H
functionalization
approaches
that
make
use
low
energy
photons
as
a
controllable
source.
Compared
to
traditional
strategies,
photocatalysis
paves
the
way
toward
complementary
and/or
previously
unattainable
regio-
chemoselectivities.
Merging
compelling
benefits
with
workflow
offers
potentially
unmatched
arsenal
tackle
drug
development
campaigns
beyond.
This
Review
highlights
photocatalytic
strategies
small-molecule
drugs,
agrochemicals,
natural
products,
classified
according
targeted
bond
newly
formed
one.
Emphasis
is
devoted
identifying,
describing,
comparing
main
mechanistic
scenarios.
draws
critical
comparison
between
established
ionic
chemistry
photocatalyzed
radical-based
manifolds.
aims
establish
current
state-of-the-art
illustrate
key
unsolved
challenges
be
addressed
in
future.
authors
aim
introduce
general
readership
functionalization,
specialist
practitioners
evaluation
methodologies,
potential
for
improvement,
future
uncharted
directions.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(28), С. 12567 - 12583
Опубликована: Июль 11, 2022
Visible-light
photocatalysis
and
electrocatalysis
are
two
powerful
strategies
for
the
promotion
of
chemical
reactions
that
have
received
tremendous
attention
in
recent
years.
In
contrast,
processes
combine
these
modalities,
an
area
termed
electrophotocatalysis,
until
recently
remained
quite
rare.
However,
over
past
several
years
a
number
reports
this
shown
potential
combining
power
light
electrical
energy
to
realize
new
catalytic
transformations.
Electrophotocatalysis
offers
ability
perform
photoredox
without
need
large
quantities
stoichiometric
or
superstoichiometric
oxidants
reductants
by
making
use
electrochemical
as
electron
source
sink.
addition,
electrophotocatalysis
is
readily
amenable
generation
open-shell
photocatalysts,
which
tend
exceptionally
strong
redox
potentials.
way,
potent
yet
selective
been
realized
under
relatively
mild
conditions.
This
Perspective
highlights
advances
provides
some
possible
avenues
future
work
growing
area.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
61(12)
Опубликована: Сен. 3, 2021
Synthetic
photoelectrochemistry
(PEC)
is
receiving
increasing
attention
as
a
new
frontier
for
the
generation
and
handling
of
reactive
intermediates.
PEC
permits
selective
single-electron
transfer
(SET)
reactions
in
much
greener
way
broadens
redox
window
possible
transformations.
Herein,
most
recent
contributions
are
reviewed,
demonstrating
exciting
opportunities,
namely,
combination
with
other
reactivity
paradigms
(hydrogen-atom
transfer,
radical
polar
crossover,
energy
sensitization),
scalability
up
to
multigram
scale,
novel
selectivities
SET
super-oxidations/reductions
importance
precomplexation
temporally
enable
excited
ion
catalysis.
Green Synthesis and Catalysis,
Год журнала:
2021,
Номер
2(2), С. 165 - 178
Опубликована: Март 29, 2021
There
is
a
resurgence
of
interests
in
organic
electrochemistry,
which
generally
accepted
as
green
synthetic
tool.
In
this
context,
many
electrochemical
methods
have
been
developed
the
past
decade
to
access
various
nitrogen-centered
radicals
(NCRs)
from
readily
available
precursors
controlled
fashion,
enabling
rapid
development
NCR-mediated
new
reactions
for
construction
nitrogen-containing
compounds.
review,
recent
advances
chemistry
electrochemically
generated
NCRs
are
critically
highlighted,
based
on
strategies
their
formation
and
types
NCRs.
Focus
put
mechanism
generation
different
applications.
