Amorphous
porous
organic
polymers
(POPs)
are
promising
filler
materials
for
mixed
matrix
membranes
(MMMs).
However,
it
is
challenging
to
synthesize
nanosized,
monodispersed
POP
colloidal
particles
(CPs)
suitable
membrane
fabrication.
Here,
well-defined
octahedral
CPs
with
imine,
ketone,
or
amine
linkages
were
synthesized
using
MOF
as
sacrificial
templates.
In
addition
shape
replication,
the
template
also
played
a
substantial
role
in
spatially
organizing
polymer
chains,
resulting
highly
POPs
that
unattainable
through
bulk
polymerization.
For
first
time,
mechanical
properties
of
single
CP
was
examined
by
quantitative
situ
compression
testing
under
scanning
electron
microscope.
Introducing
imine-linked
into
polyimide
led
series
pure-organic
defect-free
MMMs
exhibiting
excellent
homogeneity
and
flexibility.
As
result,
increasing
loading
stepwise
increase
CO2
permeability
largely
unchanged
CO2/N2
CO2/CH4
selectivity.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(24), С. 13195 - 13203
Опубликована: Июнь 12, 2023
Polymer/metal-organic
framework
(MOF)
composites
have
been
widely
studied
for
their
favorable
combination
of
polymer
flexibility
and
MOF
crystallinity.
While
traditional
polymer-coated
MOFs
maximize
the
properties
at
surface,
dramatic
loss
porosity
due
to
blockage
by
nonporous
polymeric
coating
remains
a
problem.
Herein,
we
introduce
intrinsically
microporous
synthetic
allomelanin
(AM)
as
porous
on
zirconium-based
(Zr-MOF)
UiO-66
via
an
in
situ
surface-constrained
oxidative
polymerization
AM
precursor,
1,8-dihydroxynaphthalene
(1,8-DHN).
Transmission
electron
microscopy
images
verify
formation
well-defined
nanoparticles
with
core-shell
morphology
(AM@UiO-66),
nitrogen
sorption
isotherms
indicate
core
constant
is
not
disturbed
coating.
Notably,
such
strategy
could
be
adapted
larger
pores,
MOF-808
generating
coatings
from
bulkier
DHN
oligomers,
highlighting
versatility
this
method.
Finally,
showed
that
tuning
thickness
UiO-66,
hierarchically
structures
these
AM@UiO-66
engender
excellent
hexane
isomer
separation
selectivity
storage
capacity.
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100545 - 100545
Опубликована: Янв. 14, 2023
The
development
of
engineered
living
materials
(ELMs)
has
recently
attracted
significant
attention
from
researchers
across
multiple
disciplines.
Fungi-derived
ELMs
represent
a
new
type
macroscale,
cost-effective,
environmentally
sustainable
materials.
However,
current
fungi-based
either
have
to
undergo
final
process
heat-kill
the
cells
or
rely
on
co-culture
with
model
organism
for
functional
modification,
which
hinders
engineerability
and
versatility
these
In
this
study,
we
report
-
grown
programmable
Aspergillus
niger
mycelial
pellets
by
simple
filtration
step
under
ambient
conditions.
We
demonstrate
that
A.
Niger
can
provide
sufficient
cohesion
maintain
large-area
self-supporting
structures
even
low
pH
Subsequently,
tuning
inducible
expression
genes
involved
in
melanin
biosynthesis,
verified
fabrication
membrane
tunable
colors
response
xylose
concentration
surroundings,
be
further
explored
as
potential
biosensor
detecting
level
industrial
wastewater.
Notably,
remain
alive,
self-regenerative,
after
3-month
storage.
Thus,
beyond
reporting
engineerable
fungi
chassis
constructing
ELMs,
our
study
provides
opportunities
developing
bulk
real-world
applications
such
production
fabrics,
packaging
materials,
biosensors.
Summary
Lichens
play
important
roles
in
habitat
formation
and
community
succession
polar
alpine
ecosystems.
Despite
their
significance,
the
ecological
effects
of
lichen
traits
remain
poorly
researched.
We
propose
a
trait
trade‐off
for
managing
light
exposure
based
on
climatic
harshness.
In
harshest
cold
environments,
where
abiotic
stress
predominates
over
biotic
pressures,
lichens
should
rely
photostable,
recalcitrant
immobile
substances
such
as
allomelanin
hydrophobic
compounds.
These
compounds
provide
durable
protection
without
need
continual
synthesis.
milder
conditions
interactions
–
e.g.
competition
pathogen
presence
become
increasingly
pronounced,
retain
flexibility
produce
simple
protective
secondary
that,
addition
to
functioning
screens,
can
leach
out
influence
direct
environment.
Preliminary
empirical
findings
Antarctic
species
distribution
are
consistent
with
this
hypothesised
trade‐off,
that
producing
soluble
dominate
regions
less
represented
at
higher
southern
latitudes,
insoluble
melanised
thallus
dominate.
As
climate
change
progresses,
increasing
temperatures
precipitation
could
make
currently
coldest
driest
areas
more
hospitable,
allowing
ranges
expand,
cascading
rock
weathering,
nutrient
cycling
other
ecosystem
processes.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2021,
Номер
9
Опубликована: Ноя. 16, 2021
Melanin
is
one
of
the
most
abundant
pigments
found
in
biosphere.
Owing
to
its
high
biocompatibility
and
diverse
biological
activities,
it
has
been
widely
applied
as
a
functional
biomaterial
cosmetic,
pharmaceutical,
biopolymer,
environmental
fields.
In
this
study,
production
melanin
was
comprehensively
reviewed
concerning
bioconversion
isolation
processes.
First,
several
melanogenic
microbes,
including
fungi
bacteria,
were
summarized.
classified
by
host
type
analyzed
titers
g/L
addition
reaction
conditions,
pH
temperature.
The
further
interpreted
using
space-time
yields
chart,
which
showed
two
distinct
classifications
productivity,
conditions
pH-temperature-titer
chart.
Next,
extraction
process
summarized
crude
pure
preparation
procedures,
highlighted.
Finally,
recent
applications
briefly
summarized,
prospects
for
application
development
industrial
suggested.
Journal of Fungi,
Год журнала:
2022,
Номер
9(1), С. 44 - 44
Опубликована: Дек. 28, 2022
Due
to
the
negative
environmental
and
health
effects
of
synthetic
colorants,
pigments
natural
origins
plants
microbes
constitute
an
abundant
source
for
food,
cosmetic,
textile,
pharmaceutical
industries.
The
demands
alternatives,
which
involve
colorants
biological
processes
their
production,
have
been
growing
rapidly
in
recent
decades.
Fungi
contain
some
most
prolific
pigment
producers,
they
excel
bioavailability,
yield,
cost-effectiveness,
ease
large-scale
cell
culture
as
well
downstream
processing.
In
contrast,
from
are
often
limited
by
seasonal
geographic
factors.
Here,
we
delineate
taxonomy
pigmented
fungi
fungal
pigments,
with
a
focus
on
biosynthesis
four
major
categories
pigments:
carotenoids,
melanins,
polyketides,
azaphilones.
molecular
mechanisms
metabolic
bases
governing
discussed.
Furthermore,
summarize
factors
that
known
impact
synthesis
different
pigments.
Most
enhance
production
related
stresses.
Finally,
highlight
challenges
facing
utilization
future
trends
development.
This
integrated
review
will
facilitate
further
exploitations
broad
applications.
npj Regenerative Medicine,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 2, 2023
Abstract
In
acute
skin
injury,
healing
is
impaired
by
the
excessive
release
of
reactive
oxygen
species
(ROS).
Melanin,
an
efficient
scavenger
radical
in
skin,
performs
a
key
role
ROS
scavenging
response
to
UV
radiation
and
upregulated
toxic
insult.
chemical
injury
model
mice,
we
demonstrate
that
topical
application
synthetic
melanin
particles
(SMPs)
significantly
decreases
edema,
reduces
eschar
detachment
time,
increases
rate
wound
area
reduction
compared
vehicle
controls.
Furthermore,
these
results
were
replicated
UV-injury
model.
Immune
array
analysis
shows
downregulated
gene
expression
apoptotic
inflammatory
signaling
pathways
consistent
with
histological
apoptosis.
Mechanistically,
intervention
superoxide
dismutase
(SOD)
activity,
Mmp9
expression,
suppresses
ERK1/2
phosphorylation.
observed
SMPs
caused
increased
populations
anti-inflammatory
immune
cells
accumulate
mirroring
their
decrease
from
splenic
populations.
To
enhance
antioxidant
capacity,
engineered
biomimetic
High
Surface
Area
SMP
was
deployed,
exhibiting
efficiency.
Finally,
human
explants,
decreased
damage
injury.
Therefore,
are
promising
effective
candidates
as
therapies
for
accelerated
healing,
including
via
validated
skin.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5862 - 5862
Опубликована: Май 28, 2024
Nanotechnology
is
revolutionizing
fields
of
high
social
and
economic
impact.
such
as
human
health
preservation,
energy
conversion
storage,
environmental
decontamination,
art
restoration.
However,
the
possible
global-scale
application
nanomaterials
raising
increasing
concerns,
mostly
related
to
toxicity
materials
at
nanoscale.
The
possibility
using
in
cosmetics,
hence
products
aimed
be
applied
directly
body,
even
just
externally,
strongly
debated.
Preoccupation
arises
especially
from
consideration
that
are
synthetic
origin,
often
seen
"artificial"
their
effects
unpredictable.
Melanin,
this
framework,
a
unique
material
since
nature
it
plays
important
roles
specific
cosmetics
cover,
photoprotection
hair
skin
coloration.
Moreover,
melanin
present
form
nanoparticles,
clearly
observable
ink
some
animals,
like
cuttlefish.
artificial
nanoparticles
share
same
biocompatibility
natural
ones
chemical
photochemical
properties.
Melanin
nanocosmetic
agent,
but
its
actual
still
under
development,
also
because
regulatory
issues.
Here,
we
critically
discuss
most
recent
examples
biomimetic
highlight
requirements
future
steps
would
improve
melanin-based
view
applications
everyday
market.
