Lymph node-inspired immunoregulatory hydrogel with siRNA delivery property for postoperative glioblastoma treatment DOI Creative Commons

Zide Wang,

Huimin Geng, Yuqi Zhang

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 476, С. 146343 - 146343

Опубликована: Окт. 11, 2023

Glioblastoma multiforme (GBM) is a refractory malignant tumor of the central nervous system; treating GBM remains challenging because many drugs cannot cross blood–brain barrier (BBB). The presence meningeal lymphatic vessels indicates significant potential for with immunotherapy. However, limited immune cell numbers and immunosuppressive microenvironment present additional challenges. Lymph nodes (LNs) play crucial roles in antitumor immunity, including facilitating cellular interactions lymphocyte expansion. Inspired by LN functions, we constructed an acid-responsive hydrogel to enhance local therapy efficacy. Local injection this into surgical cavity bypassed BBB reversed adenosine-induced delivering small interfering RNA (siRNA) knockdown ecto-5′-nucleotidase. Antigen release induced doxorubicin, imidazoquinoline, established inflammatory promote interaction expansion, significantly improving clearance. Overall, study presents novel approach immunotherapy that inspired functions demonstrates promising clinical translational value future treatments.

Язык: Английский

Recent Advances in Biomimetic Strategies for the Immunotherapy of Glioblastoma DOI

Haoyu You,

Shuo Geng,

Shangkuo Li

и другие.

Biomaterials, Год журнала: 2024, Номер 311, С. 122694 - 122694

Опубликована: Июнь 28, 2024

Язык: Английский

Процитировано

11
Simultaneous co-delivery of Ginsenoside Rg3 and Imiquimod from PLGA nanoparticles for effective breast cancer immunotherapy DOI Creative Commons
Cong Hu,

S H Nong,

Qianqian Ke

и другие.

iScience, Год журнала: 2025, Номер 28(5), С. 112274 - 112274

Опубликована: Март 22, 2025

Breast cancer is a fatal malignancy facing human health, with most patients experiencing recurrence and resistance to chemotherapy. The immunosuppressive tumor microenvironment (TME) greatly limits the actual outcome of immunotherapy. This study aimed develop modality theranostics nanoparticles for breast based on near-infrared light-triggered nanoparticle targeted delivery ginsenoside Rg3 immune adjuvants imiquimod (R837) effective Folate-receptor (FA) targeting IR780-R837/ginsenoside Rg3-perfluorohexane (PFH) @ polyethylene glycol (PEG)-poly (lactide-co-glycolic acid) (PLGA) (FA-NPs) can be activated by laser irradiation in tumors, which leads rapid release R837 regions high expression folate receptors glucose transporter 1 (GLUT1). Meanwhile, used as dual-mode contrast agents photoacoustic ultrasound imaging. strategy provides strong memory effect, prevent after eliminating initial tumor.

Язык: Английский

Процитировано

1
Cell membrane coated nanoparticles as a biomimetic drug delivery platform for enhancing cancer immunotherapy DOI

Zichen Zhong,

Wen Deng,

Jian Wu

и другие.

Nanoscale, Год журнала: 2024, Номер 16(18), С. 8708 - 8738

Опубликована: Янв. 1, 2024

Cancer immunotherapy, a burgeoning modality for cancer treatment, operates by activating the autoimmune system to impede growth of malignant cells. Although numerous immunotherapy strategies have been employed in clinical therapy, resistance cells immunotherapeutic medications and other apprehensions attainment sustained advantages most patients. Recent advancements nanotechnology drug delivery hold promise augmenting efficacy immunotherapy. However, is currently constrained inadequate specificity delivery, low rate response, intricate immunosuppressive tumor microenvironment. In this context, investigation cell membrane coated nanoparticles (CMNPs) has revealed their ability perform targeted immune evasion, controlled release, immunomodulation. By combining advantageous features natural membranes nanoparticles, CMNPs demonstrated unique potential realm This review aims emphasize recent research progress elucidate underlying mechanisms as an innovative platform enhancing Additionally, it provides comprehensive overview current involving different types CMNPs, with intention further exploration optimization.

Язык: Английский

Процитировано

8
In situ administration of STING-activating hyaluronic acid conjugate primes anti-glioblastoma immune response DOI Creative Commons
Teenesha Chellen, Mathilde Bausart,

Pierre Maus

и другие.

Materials Today Bio, Год журнала: 2024, Номер 26, С. 101057 - 101057

Опубликована: Апрель 16, 2024

Glioblastoma (GBM) is an aggressive brain tumor, with a highly immunosuppressive tumor immune microenvironment (TIME). In this work, we investigated the use of STimulator INterferon Genes (STING) pathway as effective means to remodel GBM TIME through recruitment both innate and adaptive cell populations. Using hyaluronic acid (HA), developed novel polymer-drug conjugate non-nucleotide STING agonist (MSA2), called HA-MSA2 for in situ treatment GBM. JAWSII cells, exerted greater increase signaling upregulation STING-related downstream cyto-/chemokines cells than free drug. also elicited cancer cell-intrinsic immunostimulatory gene expression promoted immunogenic death cells. SB28 model, local delivery induced delay growth significant extension survival. The analysis showed profound shift landscape after treatment, higher infiltration by including dendritic, natural killer (NK) CD8 T therapeutic potential polymer warrants further investigation, particularly other chemo-immunotherapeutics or vaccines promising combinatorial approach.

Язык: Английский

Процитировано

4
Key Lipoprotein Receptor Targeted Echinacoside-Liposomes Effective Against Parkinson’s Disease in Mice Model DOI Creative Commons
Zemin Ou, Yun You,

Hong Yi

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 8463 - 8483

Опубликована: Авг. 1, 2024

Introduction: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in substantia nigra.The precise molecular mechanisms underlying neuronal loss PD remain unknown, and there are currently no effective treatments for PD-associated neurodegeneration.Echinacoside (ECH) known its neuroprotective effects, which include scavenging cellular reactive oxygen species promoting mitochondrial fusion.However, blood-brain barrier (BBB) limits bioavailability ECH brain, posing significant challenge to use treatment.Methods: We synthesized PEGylated liposomes (ECH@Lip) peptide angiopep-2 (ANG) modified (ECH@ANG-Lip).The density ANG ANG-Lip was optimized using bEnd.3cells.The brain-targeting ability assessed vitro transwell BBB model vivo an imaging system LC-MS.We evaluated enhanced properties this formulation 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model. Results:The ECH@ANG-Lip demonstrated significantly higher whole-brain uptake compared ECH@Lip free ECH.Furthermore, more mitigating MPTP-induced behavioral impairment, oxidative stress, dopamine depletion, neuron death than both ECH. Conclusion:The used our study efficacy model.Thus, shows considerable potential improving providing effects brain.

Язык: Английский

Процитировано

4
Cerebral biomimetic nano-drug delivery systems: A frontier strategy for immunotherapy DOI
Hao Tian, Jiaxin Yao,

Qi Ba

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 1039 - 1067

Опубликована: Ноя. 8, 2024

Язык: Английский

Процитировано

4
Neutrophil-like pH-responsive pro-efferocytic nanoparticles improve neurological recovery by promoting erythrophagocytosis after intracerebral hemorrhage DOI Creative Commons

Linfeng Fan,

Lulu Jin,

Tianchi Tang

и другие.

Theranostics, Год журнала: 2023, Номер 14(1), С. 283 - 303

Опубликована: Ноя. 15, 2023

Rationale: Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease resulting from blood extravasating into the brain parenchyma.Escalation of erythrophagocytosis (a form efferocytosis), avoiding consequent release detrimental erythrocyte lysates, may be promising target ICH management.The ADAM17 inhibitor and liver X receptor (LXR) agonist could promote efficient efferocytosis injury repair.Nevertheless, poor bioavailability restriction blood-brain barrier (BBB) hinder their application.Therefore, it needed that biocompatible smart nanoplatforms were designed synthesized to realize effective therapy targeting erythrophagocytosis.Methods: We first assessed synergistic effect therapeutic GW280264X (an inhibitor) desmosterol LXR agonist) on in vitro.Then pH-responsive neutrophil membrane-based nanoplatform (NPEOz) served as carrier accurately deliver damaged was prepared via co-extrusion.Afterwards, performance valued vitro ability through fluorescence image vivo.Finally, pro-erythrophagocytic anti-neuroinflammatory nanomedicine related mechanisms investigated.Results: After synergistical above two drugs confirmed, we successfully developed neutrophil-disguised nanoparticles efficiently co-deliver them.The responsively agents under acidic environments, elicit favorable biocompatibility sites.D&G@NPEOz enhanced inhibiting shedding efferocytotic receptors MERTK/AXL mediated by accelerating ABCA-1/ABCG-1-mediated cholesterol efflux regulated respectively.In addition, nano-formulation able modulate inflammatory microenvironment transforming efferocytes towards phenotype with reducing proinflammatory cytokines while increasing secretion anti-inflammatory factors, improve neurological function.Conclusions: This biomimetic envisaged offer an encouraging strategy effectively hematoma inflammation resolution, consequently alleviate progression.

Язык: Английский

Процитировано

9
A novel brain targeting MnOx-based MI-3 nanoplatform for immunogenic cell death initiated high-efficiency antitumor immunity against orthotopic glioblastoma DOI
Xuejie Wang, Zhanfeng Wang,

Ping’an Ma

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150525 - 150525

Опубликована: Март 18, 2024

Язык: Английский

Процитировано

3
Current status and research progress of minimally invasive treatment of glioma DOI Creative Commons
Hao Wu, Feng Zhou, Wenwen Gao

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Май 21, 2024

Glioma has a high malignant degree and poor prognosis, which seriously affects the prognosis of patients. Traditional treatment methods mainly include craniotomy tumor resection, postoperative radiotherapy chemotherapy. Although above have achieved remarkable curative effect, they still certain limitations adverse reactions. With introduction concept minimally invasive surgery its clinical application as well development progress imaging technology, glioma become research hotspot in field neuromedicine, including photothermal treatment, photodynamic therapy, laser-induced thermal theraphy TT-Fields tumor. These therapeutic possess advantages precision, invasive, quick recovery significant been widely used practice. The purpose this review is to introduce recent years achievements prospects for future.

Язык: Английский

Процитировано

3
Donor Substitution Engineering of Hemicyanine Nanoparticles to Reprogram the Tumor Microenvironment and Enhance Fn14‐Targeted BiTE for Glioblastoma Photoimmunotherapy DOI

Gaowei Li,

Shichao Jiang, Zongliang Zhang

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Abstract Glioblastoma (GBM) is a highly malignant intracranial tumor with limited treatment options. Bispecific T‐cell engagers (BiTEs) are being explored for GBM treatment, but their success hindered by inadequate T cell infiltration and activation due to the acidic immunosuppressive microenvironment. Photothermal immunotherapy lyses tumors activates immune responses, complementing BiTEs. This study innovatively employs donor engineering strategy develop hemicyanine dyes (Hcys) that emit from near‐infrared (NIR) I NIR II. The Hcy excellent properties encapsulated in an amphiphilic micelle, forming nano assembly lactate oxidase (PLH1100). PLH1100 exhibits spectral absorption at 980 nm, photothermal conversion efficiency of 58.7%, capability NIR‐II imaging. Besides ablation, regulates lactic acid metabolism immunogenic death, improving microenvironment promoting activation. Further studies demonstrate effectively kills human murine cells, inhibits orthotopic U87 growth BALB/c‐nu mice, enhances efficacy Fn14‐targeted BiTE GL261 C57BL/6 achieving synergistic “1+1>2” therapeutic effect. Collectively, this work opens new pathway using Hcy‐based molecules combined drugs therapy, significant clinical potential.

Язык: Английский

Процитировано

3