Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100582 - 100582

Опубликована: Фев. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Язык: Английский

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Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy

Coordination Chemistry Reviews, Год журнала: 2023, Номер 496, С. 215426 - 215426

Опубликована: Сен. 6, 2023

Язык: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Год журнала: 2024, Номер 124(5), С. 2699 - 2804

Опубликована: Фев. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Язык: Английский

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Photothermal antibacterial materials to promote wound healing

Journal of Controlled Release, Год журнала: 2023, Номер 363, С. 180 - 200

Опубликована: Сен. 27, 2023

Язык: Английский

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Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Chemical Reviews, Год журнала: 2023, Номер 123(18), С. 11047 - 11136

Опубликована: Сен. 7, 2023

Advances in nanotechnology and nanomaterials have attracted considerable interest play key roles scientific innovations diverse fields. In particular, increased attention has been focused on carbon-based exhibiting extended structures unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, nanodiamonds, dots, possess excellent bioaffinities superior fluorescence properties that make suitable for application to environmental biological sensing, imaging, therapeutics. This review provides a systematic overview of the classification structural properties, design principles preparation methods, optical sensing applications nanomaterials. Recent interesting breakthroughs sensitive selective imaging heavy metal pollutants, hazardous substances, bioactive molecules as well information encryption, super-resolution photoacoustic phototherapy nanomedicine delivery are main focus this review. Finally, future challenges prospects materials highlighted envisaged. presents comprehensive basis directions designing, developing, applying fascinating fluorescent sensors fabricated based specific requirements numerous research

Язык: Английский

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Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4392 - 4442

Опубликована: Янв. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Язык: Английский

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Two-dimensional antibacterial materials

Progress in Materials Science, Год журнала: 2022, Номер 130, С. 100976 - 100976

Опубликована: Июнь 13, 2022

Язык: Английский

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Thermoresponsive Hydrogel‐Enabled Thermostatic Photothermal Therapy for Enhanced Healing of Bacteria‐Infected Wounds

Advanced Science, Год журнала: 2023, Номер 10(11)

Опубликована: Фев. 12, 2023

Abstract Photothermal therapy (PTT) has emerged as an attractive technique for the treatment of bacterial infections. However, uncontrolled heat generation in conventional PTT inevitably causes thermal damages to healthy tissues and/or organs. It is thus essential develop a smart and universal strategy regulate photothermal equilibrium temperature preset safe threshold. Herein, thermoresponsive hydrogel‐enabled thermostatic system enhanced healing bacteria‐infected wounds reported. In this system, near‐infrared (NIR)‐triggered by nanomaterials spontaneously transferred hydrogel with lower critical solution (LCST), leading its rapid phase transition forming considerable light‐scattering centers block NIR penetration. Such dynamic reversible process automatically regulates phase‐transition point LCST‐type hydrogel. contrast temperature‐uncontrolled severe damages, provides effective protection on organs, which remarkably accelerates wound efficient eradication. This study establishes smart, simple platform, holding great promise skin

Язык: Английский

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An AIE Photosensitizer with Simultaneous Type I and Type II ROS Generation: Efficient Bacterial Elimination and Hypoxic Tumor Ablation

Advanced Functional Materials, Год журнала: 2023, Номер 33(33)

Опубликована: Апрель 25, 2023

Abstract Aggregation induced emission (AIE) photosensitizers have attracted great attention due to their good performance in photodynamic therapy (PDT). However, the therapeutic effect of AIE photosensitizer is often highly dependent on biological microenvironment because it difficult produce type I and II reactive oxygen species (ROS) simultaneously. Herein, an electron‐rich anion‐ π + AIEgen Pys‐QM‐TT reported, which capable generating ROS realizing near‐infrared fluorescence imaging synchronously. In rational design photosensitizer, strong electron‐donating triphenylamine unit, π‐bridge thiophene electron‐withdrawing pyridinium salt unit can enhance D–π–A behavior, thereby improving intramolecular charge transfer extending wavelength. Meanwhile, powerful supposed reduce ∆ E S‐T promote intersystem crossing processes, thus increasing generation ROS. addition, negatively charged anion group provides environment for excited so as electron generate Therefore, not only simultaneously with weak environmental dependence, but also effectively inhibit bacterial infections ablate tumor tissue by promoting cell apoptosis, inhibiting proliferation anti‐angiogenesis.

Язык: Английский

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Polydopamine, harness of the antibacterial potentials-A review

Materials Today Bio, Год журнала: 2022, Номер 15, С. 100329 - 100329

Опубликована: Июнь 1, 2022

Antibiotic resistance is one of the major causes morbidity and mortality, triggered by adhesion microbes to some extent formation biofilms. This condition has been quite challenging in health industrial sector. Conditions processes required foil these infectious are much concern. The synthesis PDA material, inspired Mytilus edulis foot protein (MEFP)5 possesses unique characteristics that allow for, adhesion, photothermal therapy, synergistic effects with other materials, biocompatibility process, etc. Therefore, their usage holds great potential for dealing both nature antibiotic processes. Hence, this review provides an overview mechanism involved accomplishing eradicating bacteria, recently harnessed antibacterial effect through properties they possess, a way forward tapping benefit embedded PDA, future perspective.

Язык: Английский

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