Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

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Room-temperature self-healing supramolecular polyurethanes based on the synergistic strengthening of biomimetic hierarchical hydrogen-bonding interactions and coordination bonds

Chemical Engineering Journal, Год журнала: 2022, Номер 451, С. 138673 - 138673

Опубликована: Авг. 18, 2022

Язык: Английский

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Dynamic crosslinking compatibilizes immiscible mixed plastics

Nature, Год журнала: 2023, Номер 616(7958), С. 731 - 739

Опубликована: Апрель 26, 2023

Язык: Английский

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Closed-loop chemical recycling of cross-linked polymeric materials based on reversible amidation chemistry

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Дек. 9, 2022

Abstract Closed-loop chemical recycling provides a solution to the end-of-use problem of synthetic polymers. However, it remains major challenge design dynamic bonds, capable effective bonding and reversible cleaving, for preparing chemically recyclable cross-linked Herein, we report maleic acid tertiary amide bond based upon amidation reaction between anhydrides secondary amines. This allows construction polymer networks with tailorable robust mechanical properties, covering strong elastomers tensile strength 22.3 MPa rigid plastics yield 38.3 MPa. Impressively, these polymeric materials can be completely depolymerized in an acidic aqueous at ambient temperature, leading efficient monomer recovery >94% separation yields. Meanwhile, recovered monomers used remanufacture without losing their original performance. work unveils general approach tunable performance closed-loop recyclability, which will open new avenue sustainable materials.

Язык: Английский

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A Chemically Recyclable Crosslinked Polymer Network Enabled by Orthogonal Dynamic Covalent Chemistry

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(39)

Опубликована: Авг. 4, 2022

Chemical recycling of synthetic polymers offers a solution for developing sustainable plastics and materials. Here we show that two types dynamic covalent chemistry can be orthogonalized in solvent-free polymer network thus enable chemically recyclable crosslinked material. Using simple acylhydrazine-based 1,2-dithiolane as the starting material, disulfide-mediated reversible polymerization acylhydrazone-based crosslinking combined one-pot reaction, resulting mechanically robust, tough, processable The bonds both backbones crosslinkers endow with depolymerization capability under mild conditions and, importantly, virgin-quality monomers recovered separated. This proof-of-concept study opportunities to design materials based on toolbox.

Язык: Английский

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Reversible Wet‐Adhesive and Self‐Healing Conductive Composite Elastomer of Liquid Metal

Advanced Functional Materials, Год журнала: 2022, Номер 32(35)

Опубликована: Июнь 22, 2022

Abstract Stretchable conductors with the combination of high elasticity and electric conductivity have long been pursued in soft electronics. Liquid metals (LMs), whose mechanical properties match well elastomeric matrix, successfully applied robotics, electronic skins wearable devices. But it remains challenging to develop conductive composite elastomers LMs reversible adhesion self‐healing. Herein, EGaIn droplets are uniformly dispersed into elastomer, which contain dynamic disulfide endow elastomer thermal processability, recyclability, wet adhesion, With content ≥40 vol.%, resultant shows 1.3 × 104 S m −1 , self‐healing 8.0 h, strength up 670 kPa after curing for 2.0 h. When serving as adhesive, can easily adhere metal electrode light LED even when stretched 50%. self‐adhesive bioelectrode, also detect human electromyography signals. Thus, not only may this study provide a new platform designing self‐adhesive, self‐healing, liquid metals, but their promise facileness building damage‐endurable electronics applying human–machine interfaces.

Язык: Английский

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Self-healing, self-adhesive, and stretchable conductive hydrogel for multifunctional sensor prepared by catechol modified nanocellulose stabilized poly(α-thioctic acid)

Carbohydrate Polymers, Год журнала: 2023, Номер 313, С. 120813 - 120813

Опубликована: Март 16, 2023

Язык: Английский

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Robust and dynamic underwater adhesives enabled by catechol-functionalized poly(disulfides) network

National Science Review, Год журнала: 2022, Номер 10(2)

Опубликована: Июль 25, 2022

Developing molecular approaches to the creation of robust and water-resistant adhesive materials promotes a fundamental understanding interfacial adhesion mechanisms as well future applications biomedical materials. Here, we present simple strategy that combines natural thioctic acid mussel-inspired iron-catechol complexes enable ultra-strong can be used underwater simultaneously exhibit unprecedentedly high strength on diverse surfaces. Our experimental results show crosslinking interaction complexes, high-density hydrogen bonding, are responsible for ultra-high strength. The embedding effect hydrophobic solvent-free network poly(disulfides) further enhances water-resistance. dynamic covalent also makes resulting reconfigurable, thus enabling reusability via repeated heating cooling. This molecule-engineering offers general versatile solution design construction supramolecular

Язык: Английский

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New Advances in Covalent Network Polymers via Dynamic Covalent Chemistry

Chemical Reviews, Год журнала: 2024, Номер 124(12), С. 7829 - 7906

Опубликована: Июнь 3, 2024

Covalent network polymers, as materials composed of atoms interconnected by covalent bonds in a continuous network, are known for their thermal and chemical stability. Over the past two decades, these have undergone significant transformations, gaining properties such malleability, environmental responsiveness, recyclability, crystallinity, customizable porosity, enabled development integration dynamic chemistry (DCvC). In this review, we explore innovative realm polymers focusing on recent advances achieved through application DCvC. We start examining history fundamental principles DCvC, detailing its inception core concepts noting key role reversible bond formation. Then reprocessability DCvC is thoroughly discussed, starting from milestones that marked evolution progressing to current trends applications. The influence crystallinity then reviewed, covering diversity, synthesis techniques, functionalities. concluding section, address challenges faced field speculates potential future directions.

Язык: Английский

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Building Tunable Degradation into High-Performance Poly(acrylate) Pressure-Sensitive Adhesives

ACS Macro Letters, Год журнала: 2023, Номер 12(6), С. 787 - 793

Опубликована: Май 23, 2023

Pressure-sensitive adhesives (PSAs) based on poly(acrylate) chemistry are common in a wide variety of applications, but the absence backbone degradability causes issues with recycling and sustainability. Here, we report strategy to create degradable PSAs using simple, scalable, functional 1,2-dithiolanes as drop-in replacements for traditional acrylate comonomers. Our key building block is α-lipoic acid, natural, biocompatible, commercially available antioxidant found various consumer supplements. α-Lipoic acid its derivative ethyl lipoate efficiently copolymerize n-butyl under conventional free-radical conditions leading high-molecular-weight copolymers (Mn > 100 kg mol-1) containing tunable concentration disulfide bonds along backbone. The thermal viscoelastic properties these materials practically indistinguishable from nondegradable analogues, significant reduction molecular weight realized upon exposure reducing agents such tris (2-carboxyethyl) phosphine (e.g., Mn = 198 mol-1 → 2.6 mol-1). By virtue thiol chain ends produced after cleavage, degraded oligomers can be further cycled between high low weights through oxidative repolymerization reductive degradation. Transforming otherwise persistent poly(acrylates) into recyclable simple versatile could play pivotal role improving sustainability contemporary adhesives.

Язык: Английский

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