Natural Compounds Targeting the Autophagy Pathway in the Treatment of Colorectal Cancer DOI Open Access

Yin-Xiao Du,

Abdullah Al Mamun,

Aiping Lyu

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7310 - 7310

Опубликована: Апрель 15, 2023

Autophagy is a highly conserved intracellular degradation pathway by which misfolded proteins or damaged organelles are delivered in double-membrane vacuolar vesicle and finally degraded lysosomes. The risk of colorectal cancer (CRC) high, there growing evidence that autophagy plays critical role regulating the initiation metastasis CRC; however, whether promotes suppresses tumor progression still controversial. Many natural compounds have been reported to exert anticancer effects enhance current clinical therapies modulating autophagy. Here, we discuss recent advancements molecular mechanisms CRC. We also highlight research on particularly promising modulators for CRC treatment with evidence. Overall, this review illustrates importance provides perspectives these regulators as new therapeutic candidates drug development.

Язык: Английский

Coumarins as versatile therapeutic phytomolecules: A systematic review DOI
Mohd Kamil Hussain,

Shahnaaz Khatoon,

Mohammad Faheem Khan

и другие.

Phytomedicine, Год журнала: 2024, Номер 134, С. 155972 - 155972

Опубликована: Авг. 30, 2024

Язык: Английский

Процитировано

14

Co-Assembled Binary Polyphenol Natural Products for the Prevention and Treatment of Radiation-Induced Skin Injury DOI
Yanwei Hu,

Yuhang Miao,

Yan Zhang

и другие.

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Radiation therapy, a fundamental treatment for tumors, is often accompanied by radiation-induced skin injury (RISI). Excessive production of reactive oxygen species (ROS) and subsequent inflammation are two key factors in RISI development that will cause affect radiotherapy. Herein, the co-assembled binary polyphenol natural products inspired dual-functional cascade microneedle system prevention RISI. Specifically, epigallocatechin gallate (EGCG) curcumin (CUR) were into nanoparticles (CEPG) intermolecular interactions then incorporated with catalase (CAT) to achieve microneedles (this was conducive penetrate epidermal keratinocytes where had greatest impact). When using microneedles, tip dissolved rapidly delivered CEPG CAT dermis, NPs able respond ROS decompose EGCG CUR. More importantly, formed converts superoxide anions water step-by-step, which can reduce cell damage caused free radicals early stages radiation prevention; meanwhile, CUR inhibited inflammatory pathways, achieving post-radiotherapy period. These explorations broaden strategy application

Язык: Английский

Процитировано

11

Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke DOI Creative Commons
Lin Cheng,

Shangbin Lv,

Wei Chen

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 7, 2025

Mitochondria, as the energy factories of cells, are involved in a wide range vital activities, including cell differentiation, signal transduction, cycle, and apoptosis, while also regulating growth. However, current pharmacological treatments for stroke challenged by issues such drug resistance side effects, necessitating exploration new therapeutic strategies. This review aims to summarize regulatory effects natural compounds targeting mitochondria on neuronal mitochondrial function metabolism, providing perspectives treatment. Numerous vitro vivo studies have shown that products berberine, ginsenosides, baicalein protect reduce stroke-induced damage through multiple mechanisms. These apoptosis modulating expression mitochondrial-associated apoptotic proteins. They inhibit activation permeability transition pore (mPTP), thereby decreasing ROS production cytochrome C release, which helps preserve function. Additionally, they regulate ferroptosis, fission, promote autophagy trafficking, further enhancing protection. As multi-target chemical agents, offer high efficacy with fewer present promising potential innovative therapies. Future research should investigate effectiveness safety these clinical applications, advancing their development strategy stroke.

Язык: Английский

Процитировано

2

Betulonic acid: A review on its sources, biological activities, and molecular mechanisms DOI

Shengying Lou,

Chunyan Dai,

Yuhua Wu

и другие.

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177518 - 177518

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor DOI
Jiaming Li,

Hongda Sheng,

Yingchao Wang

и другие.

Journal of Medicinal Chemistry, Год журнала: 2023, Номер 66(4), С. 2946 - 2963

Опубликована: Фев. 14, 2023

Natural products provide inspiration and have proven to be the most valuable source for drug discovery. Herein, we report a scaffold hybrid strategy of Tanshinone I discovery NLRP3 inflammasome inhibitors. 36 compounds were designed synthesized, cheminformatic analyses showed that these occupy unique chemical space. The biological evaluation identified 5j, 12a, 12d as inhibitors with significant potency, selectivity, drug-likeness. Mechanistic studies revealed derivatives could inhibit degradation protein block oligomerization NLRP3-induced apoptosis-associated speck-like proteins, thus inhibiting activation. In addition, water solubility, in vitro metabolic stability, oral bioavailability also greatly improved compared I. Therefore, this protocol provides new structural evolution class potent

Язык: Английский

Процитировано

22

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP DOI Creative Commons
Marko Cigler, Hana Imrichová, Fabian Frommelt

и другие.

Nature Chemical Biology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 21, 2024

Metabolic alterations in cancer precipitate associated dependencies that can be therapeutically exploited. To meet this goal, natural product-inspired small molecules provide a resource of invaluable chemotypes. Here, we identify orpinolide, synthetic withanolide analog with pronounced antileukemic properties, via orthogonal chemical screening. Through multiomics profiling and genome-scale CRISPR-Cas9 screens, orpinolide disrupts Golgi homeostasis mechanism requires active phosphatidylinositol 4-phosphate signaling at the endoplasmic reticulum-Golgi membrane interface. Thermal proteome genetic validation studies reveal oxysterol-binding protein OSBP as direct phenotypically relevant target orpinolide. Collectively, these data reaffirm sterol transport actionable dependency leukemia motivate ensuing translational investigation probe-like compound

Язык: Английский

Процитировано

9

Exploring the Anticancer Potential and Mechanisms of Action of Natural Coumarins and Isocoumarins DOI

Mohd Aqib,

Shahnaaz Khatoon,

Mujahid Ali

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 282, С. 117088 - 117088

Опубликована: Ноя. 22, 2024

Язык: Английский

Процитировано

9

Polymers showing cluster triggered emission as potential materials in biophotonic applications DOI
Roger Bresolí‐Obach, José A. Castro‐Osma, Santi Nonell

и другие.

Journal of Photochemistry and Photobiology C Photochemistry Reviews, Год журнала: 2024, Номер 58, С. 100653 - 100653

Опубликована: Янв. 25, 2024

Язык: Английский

Процитировано

8

A divergent intermediate strategy yields biologically diverse pseudo-natural products DOI Creative Commons
Sukdev Bag, Jie Liu, Sohan Patil

и другие.

Nature Chemistry, Год журнала: 2024, Номер 16(6), С. 945 - 958

Опубликована: Фев. 16, 2024

Abstract The efficient exploration of biologically relevant chemical space is essential for the discovery bioactive compounds. A molecular design principle that possesses both biological relevance and structural diversity may more efficiently lead to compound collections are enriched in diverse bioactivities. Here pseudo-natural product (PNP) strategy, which combines PNP concept with synthetic diversification strategies from diversity-oriented synthesis, reported. collection was synthesized a common divergent intermediate through developed indole dearomatization methodologies afford three-dimensional frameworks could be further diversified via intramolecular coupling and/or carbon monoxide insertion. In total, 154 PNPs were representing eight different classes. Cheminformatic analyses showed structurally between Biological investigations revealed extent bioactivity enrichment four inhibitors Hedgehog signalling, DNA de novo pyrimidine biosynthesis tubulin polymerization identified

Язык: Английский

Процитировано

8

New drug discovery and development from natural products: Advances and strategies DOI
Yixin Wang,

Fan Wang,

Wenxiu Liu

и другие.

Pharmacology & Therapeutics, Год журнала: 2024, Номер 264, С. 108752 - 108752

Опубликована: Ноя. 16, 2024

Язык: Английский

Процитировано

8