International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 7310 - 7310
Опубликована: Апрель 15, 2023
Autophagy
is
a
highly
conserved
intracellular
degradation
pathway
by
which
misfolded
proteins
or
damaged
organelles
are
delivered
in
double-membrane
vacuolar
vesicle
and
finally
degraded
lysosomes.
The
risk
of
colorectal
cancer
(CRC)
high,
there
growing
evidence
that
autophagy
plays
critical
role
regulating
the
initiation
metastasis
CRC;
however,
whether
promotes
suppresses
tumor
progression
still
controversial.
Many
natural
compounds
have
been
reported
to
exert
anticancer
effects
enhance
current
clinical
therapies
modulating
autophagy.
Here,
we
discuss
recent
advancements
molecular
mechanisms
CRC.
We
also
highlight
research
on
particularly
promising
modulators
for
CRC
treatment
with
evidence.
Overall,
this
review
illustrates
importance
provides
perspectives
these
regulators
as
new
therapeutic
candidates
drug
development.
Natural Product Reports,
Год журнала:
2023,
Номер
40(10), С. 1595 - 1607
Опубликована: Янв. 1, 2023
Limited
screening
focus
has
led
to
most
marine
derived
indole
alkaloids
(MIA)
being
inactive.
However,
computational
comparisons
with
drugs
suggest
MIAs
will
be
active
in
new
disease
relevant
targets
if
a
shift
is
adopted.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(15), С. 8291 - 8298
Опубликована: Апрель 7, 2023
Covalent
and
ionic
bonds
represent
two
fundamental
forms
of
bonding
between
atoms.
In
contrast
to
with
significant
covalent
character,
are
limited
use
for
the
spatial
structuring
matter
because
lack
directionality
electric
field
around
simple
ions.
We
describe
a
predictable
directional
orientation
that
contain
concave
nonpolar
shields
charged
sites.
Such
offer
an
alternative
hydrogen
other
noncovalent
interactions
organic
molecules
materials.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 7310 - 7310
Опубликована: Апрель 15, 2023
Autophagy
is
a
highly
conserved
intracellular
degradation
pathway
by
which
misfolded
proteins
or
damaged
organelles
are
delivered
in
double-membrane
vacuolar
vesicle
and
finally
degraded
lysosomes.
The
risk
of
colorectal
cancer
(CRC)
high,
there
growing
evidence
that
autophagy
plays
critical
role
regulating
the
initiation
metastasis
CRC;
however,
whether
promotes
suppresses
tumor
progression
still
controversial.
Many
natural
compounds
have
been
reported
to
exert
anticancer
effects
enhance
current
clinical
therapies
modulating
autophagy.
Here,
we
discuss
recent
advancements
molecular
mechanisms
CRC.
We
also
highlight
research
on
particularly
promising
modulators
for
CRC
treatment
with
evidence.
Overall,
this
review
illustrates
importance
provides
perspectives
these
regulators
as
new
therapeutic
candidates
drug
development.
