Natural Compounds Targeting the Autophagy Pathway in the Treatment of Colorectal Cancer DOI Open Access

Yin-Xiao Du,

Abdullah Al Mamun,

Aiping Lyu

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7310 - 7310

Опубликована: Апрель 15, 2023

Autophagy is a highly conserved intracellular degradation pathway by which misfolded proteins or damaged organelles are delivered in double-membrane vacuolar vesicle and finally degraded lysosomes. The risk of colorectal cancer (CRC) high, there growing evidence that autophagy plays critical role regulating the initiation metastasis CRC; however, whether promotes suppresses tumor progression still controversial. Many natural compounds have been reported to exert anticancer effects enhance current clinical therapies modulating autophagy. Here, we discuss recent advancements molecular mechanisms CRC. We also highlight research on particularly promising modulators for CRC treatment with evidence. Overall, this review illustrates importance provides perspectives these regulators as new therapeutic candidates drug development.

Язык: Английский

Recent advancements in natural compounds for cancer therapy and prevention DOI

R. Pavithra,

Mohammad Rashid Khan, Mohd Shahanbaj Khan

и другие.

Phytochemistry Reviews, Год журнала: 2024, Номер unknown

Опубликована: Март 28, 2024

Язык: Английский

Процитировано

7

Novel sulfonyl hydrazide based β-carboline derivatives as potential α-glucosidase inhibitors: design, synthesis, and biological evaluation DOI
Jinping Sun, Di Xiao, Ming Lang

и другие.

Molecular Diversity, Год журнала: 2024, Номер unknown

Опубликована: Авг. 14, 2024

Язык: Английский

Процитировано

7

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing? DOI
Darren C. Holland, Anthony R. Carroll

Natural Product Reports, Год журнала: 2023, Номер 40(10), С. 1595 - 1607

Опубликована: Янв. 1, 2023

Limited screening focus has led to most marine derived indole alkaloids (MIA) being inactive. However, computational comparisons with drugs suggest MIAs will be active in new disease relevant targets if a shift is adopted.

Язык: Английский

Процитировано

16

Directional Ionic Bonds DOI Creative Commons
Illia Hutskalov, Anthony Linden, Ilija Čorić

и другие.

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(15), С. 8291 - 8298

Опубликована: Апрель 7, 2023

Covalent and ionic bonds represent two fundamental forms of bonding between atoms. In contrast to with significant covalent character, are limited use for the spatial structuring matter because lack directionality electric field around simple ions. We describe a predictable directional orientation that contain concave nonpolar shields charged sites. Such offer an alternative hydrogen other noncovalent interactions organic molecules materials.

Язык: Английский

Процитировано

15

Natural Compounds Targeting the Autophagy Pathway in the Treatment of Colorectal Cancer DOI Open Access

Yin-Xiao Du,

Abdullah Al Mamun,

Aiping Lyu

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7310 - 7310

Опубликована: Апрель 15, 2023

Autophagy is a highly conserved intracellular degradation pathway by which misfolded proteins or damaged organelles are delivered in double-membrane vacuolar vesicle and finally degraded lysosomes. The risk of colorectal cancer (CRC) high, there growing evidence that autophagy plays critical role regulating the initiation metastasis CRC; however, whether promotes suppresses tumor progression still controversial. Many natural compounds have been reported to exert anticancer effects enhance current clinical therapies modulating autophagy. Here, we discuss recent advancements molecular mechanisms CRC. We also highlight research on particularly promising modulators for CRC treatment with evidence. Overall, this review illustrates importance provides perspectives these regulators as new therapeutic candidates drug development.

Язык: Английский

Процитировано

15