Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(8), P. 1122 - 1122
Published: Aug. 9, 2023
Diseases
are
evolving
as
living
standards
continue
to
improve.
Cancer
is
the
main
cause
of
death
and
a
major
public
health
problem
that
seriously
threatens
human
life.
Colorectal
cancer
one
top
ten
most
common
malignant
tumors
in
China,
ranking
second
after
gastric
among
gastrointestinal
tumors,
its
incidence
rate
increasing
dramatically
each
year
due
changes
dietary
habits
lifestyle
world’s
population.
Although
conventional
therapies,
such
surgery,
chemotherapy,
radiotherapy,
have
profoundly
impacted
treatment
colorectal
(CRC),
drug
resistance
toxicity
remain
substantial
challenges.
Natural
products,
therapeutic
agents,
considered
safest
alternative
for
treating
CRC.
In
addition,
there
evidence
natural
products
can
induce
apoptosis,
inhibit
cell
cycle
arrest,
reduce
invasion
migration
colon
cells
by
targeting
regulating
expression
function
miRNAs.
Here,
we
summarize
recent
research
findings
on
miRNA-regulation-based
antitumor
mechanisms
various
active
ingredients
highlighting
how
target
miRNA
regulation
prevention
treatment.
The
application
delivery
systems
predictive
disease
biomarkers
also
discussed.
Such
approaches
will
contribute
discovery
new
regulatory
associated
with
pathways
provide
theoretical
basis
developing
novel
drugs
compounds
identifying
targets.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(18), P. 4013 - 4017
Published: May 1, 2024
We
introduce
a
new
use
of
sulfonyl
fluoride
as
bifunctional
reagent
that
facilitates
the
one-step
deoxy-diversification
complex
alcohol
libraries.
Our
reaction
design
features
Sulfur(VI)
Fluoride
Exchange
(SuFEx)
mediated
activation
alcohols
and
fluoride-induced
silicon-bound
nucleophiles.
This
method
enables
direct
conversion
alcoholic
C–O
bonds
in
molecules
into
diverse
analogues
via
C–C,
C–N,
C–Cl,
C–Br
bond
formation
while
suppressing
any
elimination
side-products.
Natural Product Reports,
Journal Year:
2023,
Volume and Issue:
40(10), P. 1595 - 1607
Published: Jan. 1, 2023
Limited
screening
focus
has
led
to
most
marine
derived
indole
alkaloids
(MIA)
being
inactive.
However,
computational
comparisons
with
drugs
suggest
MIAs
will
be
active
in
new
disease
relevant
targets
if
a
shift
is
adopted.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7310 - 7310
Published: April 15, 2023
Autophagy
is
a
highly
conserved
intracellular
degradation
pathway
by
which
misfolded
proteins
or
damaged
organelles
are
delivered
in
double-membrane
vacuolar
vesicle
and
finally
degraded
lysosomes.
The
risk
of
colorectal
cancer
(CRC)
high,
there
growing
evidence
that
autophagy
plays
critical
role
regulating
the
initiation
metastasis
CRC;
however,
whether
promotes
suppresses
tumor
progression
still
controversial.
Many
natural
compounds
have
been
reported
to
exert
anticancer
effects
enhance
current
clinical
therapies
modulating
autophagy.
Here,
we
discuss
recent
advancements
molecular
mechanisms
CRC.
We
also
highlight
research
on
particularly
promising
modulators
for
CRC
treatment
with
evidence.
Overall,
this
review
illustrates
importance
provides
perspectives
these
regulators
as
new
therapeutic
candidates
drug
development.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(8), P. 1122 - 1122
Published: Aug. 9, 2023
Diseases
are
evolving
as
living
standards
continue
to
improve.
Cancer
is
the
main
cause
of
death
and
a
major
public
health
problem
that
seriously
threatens
human
life.
Colorectal
cancer
one
top
ten
most
common
malignant
tumors
in
China,
ranking
second
after
gastric
among
gastrointestinal
tumors,
its
incidence
rate
increasing
dramatically
each
year
due
changes
dietary
habits
lifestyle
world’s
population.
Although
conventional
therapies,
such
surgery,
chemotherapy,
radiotherapy,
have
profoundly
impacted
treatment
colorectal
(CRC),
drug
resistance
toxicity
remain
substantial
challenges.
Natural
products,
therapeutic
agents,
considered
safest
alternative
for
treating
CRC.
In
addition,
there
evidence
natural
products
can
induce
apoptosis,
inhibit
cell
cycle
arrest,
reduce
invasion
migration
colon
cells
by
targeting
regulating
expression
function
miRNAs.
Here,
we
summarize
recent
research
findings
on
miRNA-regulation-based
antitumor
mechanisms
various
active
ingredients
highlighting
how
target
miRNA
regulation
prevention
treatment.
The
application
delivery
systems
predictive
disease
biomarkers
also
discussed.
Such
approaches
will
contribute
discovery
new
regulatory
associated
with
pathways
provide
theoretical
basis
developing
novel
drugs
compounds
identifying
targets.
