Assembly and Applications of Macrocyclic-Confinement-Derived Supramolecular Organic Luminescent Emissions from Cucurbiturils

Chemical Reviews, Год журнала: 2022, Номер 122(9), С. 9032 - 9077

Опубликована: Март 21, 2022

Cucurbit[n]urils (Q[n]s or CB[n]s), as a classical of artificial organic macrocyclic hosts, were found to have excellent advantages in the fabricating tunable and smart luminescent materials aqueous media solid state with high emitting efficiency under rigid pumpkin-shaped structure-derived macrocyclic-confinement effect recent years. This review aims give systematically up-to-date overview Q[n]-based supramolecular emissions from confined spaces triggered host–guest complexes, including assembly fashions mechanisms macrocycle-based well their applications. Finally, challenges outlook are provided. Since this class emissions, which essentially derived cavity-dependent confinement resulting fashions, emerged only few years ago, we hope will provide valuable information for further development light-emitting other related research fields.

Язык: Английский

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Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(7), С. 4081 - 4087

Опубликована: Фев. 13, 2023

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved. Herein, we develop oxygen-independent supramolecular agent that produces hydroxyl radical (•OH) by oxidizing water the presence intracellularly abundant pyruvic acid under oxygen-free conditions. A fluorene-substituted BODIPY was designed as electron donor and coassembled with perylene diimide acceptor form quadruple hydrogen-bonded agent. Detailed mechanism studies reveal intermolecular transfer charge separation upon light irradiation result efficient generation ion pairs. Under conditions, cationic radicals directly oxidize generate cytotoxic •OH, anionic electrons acid, realizing catalytic cycle. Thus, this exhibited superb photocytotoxicity even severe environments excellent vivo antitumor on HeLa-bearing mouse models. This work provides a strategy for constructing agents, opens up avenue effective PDT tumors.

Язык: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Год журнала: 2024, Номер 124(5), С. 2699 - 2804

Опубликована: Фев. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Язык: Английский

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Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications

Bioactive Materials, Год журнала: 2022, Номер 21, С. 358 - 380

Опубликована: Сен. 14, 2022

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have massive potential in solving longstanding challenges existing drugs, such as poor localization at the tumor site, high doses toxicity, recurrence, immune response. However, inadequate biocompatibility restricts their clinical translation. Therefore, advanced nanomaterials with enhanced therapeutic efficiency are highly desired to fast-track translation nanomedicines. Intrinsic nanoscale covalent organic frameworks (nCOFs), suitable size, modular pore geometry porosity, straightforward post-synthetic modification via simple transformations, make them incredibly attractive future ability COFs disintegrate slightly acidic microenvironment also gives competitive advantage targeted delivery. This review summarizes recently published applications delivery, photo-immuno therapy, sonodynamic photothermal chemotherapy, pyroptosis, combination therapy. Herein we mainly focused on modifications enhance biocompatibility, efficacy will provide fundamental knowledge designing biocompatible nCOFs-based help rapid development carriers theranostics.

Язык: Английский

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Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

Advanced Functional Materials, Год журнала: 2023, Номер 33(29)

Опубликована: Июнь 9, 2023

Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.

Язык: Английский

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Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy

Coordination Chemistry Reviews, Год журнала: 2023, Номер 501, С. 215560 - 215560

Опубликована: Ноя. 27, 2023

Язык: Английский

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Photo‐Induced Disproportionation‐Mediated Photodynamic Therapy: Simultaneous Oxidation of Tetrahydrobiopterin and Generation of Superoxide Radicals

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(12)

Опубликована: Янв. 23, 2024

We herein present an approach of photo-induced disproportionation for preparation Type-I photodynamic agents. As a proof concept, BODIPY-based photosensitizers were rationally designed and prepared. The intermolecular electron transfer between homotypic chromophores leads to the reaction, resulting in formation charged intermediates, cationic anionic radicals. radicals efficiently oxidize cellularimportant coenzyme, tetrahydrobiopterin (BH

Язык: Английский

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Supramolecular systems for bioapplications: recent research progress in China

Science China Chemistry, Год журнала: 2024, Номер 67(5), С. 1397 - 1441

Опубликована: Март 22, 2024

Язык: Английский

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A Nanographene‐Porphyrin Hybrid for Near‐Infrared‐Ii Phototheranostics

Advanced Science, Год журнала: 2024, Номер 11(18)

Опубликована: Март 2, 2024

Abstract Photoacoustic imaging (PAI)‐guided photothermal therapy (PTT) in the second near‐infrared (NIR‐II, 1000–1700 nm) window has been attracting attention as a promising cancer theranostic platform. Here, it is reported that π‐extended porphyrins fused with one or two nanographene units (NGP‐1 and NGP‐2) can serve new class of NIR‐responsive organic agents, displaying absorption extending to ≈1000 ≈1400 nm NIR‐I NIR‐II windows, respectively. NGP‐1 NGP‐2 are dispersed water through encapsulation into self‐assembled nanoparticles (NPs), achieving high conversion efficiency 60% 69%, respectively, under 808 1064 laser irradiation. Moreover, NIR‐II‐active NGP‐2‐NPs demonstrated photoacoustic responses, along photostability biocompatibility, enabling PAI efficient PTT vivo.

Язык: Английский

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Boosting Theranostic Performance of AIEgens Using Nanocatalyzer for Robust Cancer Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Фев. 15, 2024

Abstract High‐performance theranostic systems are of paramount importance for achieving precise image‐guided cancer immunotherapy. Here, a novel nanoplatform is presented that integrates aggregation‐induced emission luminogen (AIEgen) with prussian blue (PB) nanocatalyzer robust The AIEgen dimethylamine substitution demonstrates compelling near‐infrared (NIR) light‐induced photothermal conversion and photodynamic therapy (PDT) capabilities. By incorporating into porous PBNPs, further enveloped within M1 macrophage membrane, tumor‐specific nanoagent constructed. This strategic integration effectively constrains the molecular motion AIEgen, leading to amplified NIR‐II fluorescence brightness PDT attributes. Moreover, PBNPs can catalyze tumor‐overexpressed H 2 O generate oxygen boost efficacy, PB's NIR absorption also intensifies photoacoustic imaging effect. provides comprehensive information photoimmunotherapy in orthotopic breast cancer‐bearing mice. Leveraging its potent immunogenic cell death effect, not only significantly inhibits growth, but generates whole‐cell therapeutic vaccine protect mice from tumor rechallenge. In highly malignant post‐surgery models, enables both accurate identification residual tumors efficient inhibition postoperative recurrence pulmonary metastasis. study will offer valuable insights creating efficacious multifaceted protocols.

Язык: Английский

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