Angewandte Chemie,
Год журнала:
2023,
Номер
135(30)
Опубликована: Апрель 20, 2023
Abstract
This
study
describes
the
development
of
a
new
type
amine‐reactive
superhydrophobic
(RSH)
film
that
is
facilely
coated
on
various
substrates
using
single‐step
process,
while
versatility
this
RSH
offers
reliable
solution
for
efficient
formation
complex
and
robust
interlayer
electrical
connectivity
(IEC)
in
3D
electronic
systems.
The
excellent
spatial
controllability
surface
amine
modification
enables
generation
vertical
circuits
situ,
providing
distinct
way
to
connect
located
different
layers.
Moreover,
inherent
superhydrophobicity
porosity
exhibit
required
anti‐fouling
breathability
properties,
making
RSH‐based
IEC
well‐suited
applications
where
exposure
environmental
gas
liquid
contaminants
likely.
approach
provides
another
avenue
towards
flexible
integrated
electronics,
opening
up
possibilities
advancement
field.
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
In
silico
examination
of
13
P
,
N
-ligated
Au(
iii
)
OACs
determined
the
key
mechanistic
factors
governing
)-mediated
S
-arylation.
Three
complexes
were
synthesized
which
exhibited
bimolecular
coordination
rate
constants
as
high
20
200
M
−1
s
.
Chemical Physics Reviews,
Год журнала:
2024,
Номер
5(3)
Опубликована: Июль 9, 2024
The
perfluoroaryl⋯aryl
interaction,
the
most
important
subset
of
π-hole⋯π
bonding,
refers
to
attractive
stacking
interaction
between
a
perfluoroaryl
group
and
an
aryl
group.
In
contrast
aryl⋯aryl
with
same
size,
much
stronger
has
its
own
characteristics
applications.
A
brief
history
development
was
given
first
in
this
review,
followed
by
overview
state-of-the-art
nature
interaction.
Much
attention
paid
application
both
traditional
research
fields
such
as
crystal
engineering
organic
luminescent
materials
hot
photovoltaics
biological
engineering.
It
is
believed
that
timely
comprehensive
review
provides
foundation
guide
for
future
De
novo
design
methods
hold
the
promise
of
reducing
time
and
cost
antibody
discovery
while
enabling
facile
precise
targeting
predetermined
epitopes.
Here,
we
describe
a
fragment-based
method
for
combinatorial
binding
loops
their
grafting
onto
scaffolds.
We
designed
tested
six
single-domain
antibodies
different
epitopes
on
three
antigens,
including
receptor-binding
domain
SARS-CoV-2
spike
protein.
Biophysical
characterization
showed
that
all
designs
are
stable
bind
intended
targets
with
affinities
in
nanomolar
range
without
vitro
affinity
maturation.
further
discuss
how
high-resolution
input
antigen
structure
is
not
required,
as
similar
predictions
obtained
when
crystal
or
computer-generated
model.
This
computational
procedure,
which
readily
runs
laptop,
provides
starting
point
rapid
generation
lead
to
preselected
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(30), С. 20709 - 20719
Опубликована: Июль 16, 2024
Chemical
post-translational
protein–protein
conjugation
is
an
important
technique
with
growing
applications
in
biotechnology
and
pharmaceutical
research.
Maleimides
represent
one
of
the
most
widely
employed
bioconjugation
reagents.
However,
challenges
associated
instability
first-
second-generation
maleimide
technologies
are
yet
to
be
fully
addressed.
We
report
development
a
novel
class
reagents
that
can
undergo
on-demand
ring-opening
hydrolysis
resulting
thio-succinimide.
This
strategy
enables
rapid
assembly
conjugates.
Thio-succinimide
hydrolysis,
triggered
upon
application
chemical,
photochemical,
or
enzymatic
stimuli,
allowed
homobifunctional
bis-maleimide
applied
production
stable
conjugates,
complete
temporal
control.
Bivalent
bispecific
dimers
constructed
from
small
binders
targeting
antigens
oncological
importance,
PD-L1
HER2,
were
generated
high
purity,
stability,
improved
functionality
compared
monomeric
building
blocks.
The
modularity
approach
was
demonstrated
through
elaboration
linker
moiety
bioorthogonal
propargyl
handle
produce
protein–protein–fluorophore
Furthermore,
extending
by
temporarily
masking
reactive
thiols
included
higher
order
trimeric
tetrameric
single-domain
antibody
potential
for
extended
proteins
greater
biochemical
complexity
immunoglobulin
On-demand
control
thio-succinimide
combined
facile
chemically
defined
homo-
heterodimers
constitutes
expansion
chemical
methods
available
generating
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(19), С. 10753 - 10771
Опубликована: Май 6, 2024
Food-borne
biotoxins
from
microbes,
plants,
or
animals
contaminate
unclean,
spoiled,
and
rotten
foods,
posing
significant
health
risks.
Neutralizing
such
toxins
is
vital
for
human
health,
especially
after
food
poisoning.
Nanobodies
(Nbs),
a
type
of
single-domain
antibodies
derived
the
genetic
cloning
variable
domain
heavy
chain
(VHHs)
in
camels,
offer
unique
advantages
toxin
neutralization.
Their
small
size,
high
stability,
precise
binding
enable
effective
The
use
Nbs
neutralizing
food-borne
offers
numerous
benefits,
their
malleability
allows
tailored
optimization
diverse
toxins.
As
nanotechnology
continues
to
evolve
improve,
are
poised
become
increasingly
efficient
safer
tools
neutralization,
playing
pivotal
role
safeguarding
environmental
safety.
This
review
not
only
highlights
efficacy
these
agents
but
also
proposes
innovative
solutions
address
current
challenges.
It
lays
solid
foundation
further
development
this
crucial
field
propels
commercial
application,
thereby
contributing
significantly
advancements
domain.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(30)
Опубликована: Апрель 20, 2023
This
study
describes
the
development
of
a
new
type
amine-reactive
superhydrophobic
(RSH)
film
that
is
facilely
coated
on
various
substrates
using
single-step
process,
while
versatility
this
RSH
offers
reliable
solution
for
efficient
formation
complex
and
robust
interlayer
electrical
connectivity
(IEC)
in
3D
electronic
systems.
The
excellent
spatial
controllability
surface
amine
modification
enables
generation
vertical
circuits
situ,
providing
distinct
way
to
connect
located
different
layers.
Moreover,
inherent
superhydrophobicity
porosity
exhibit
required
anti-fouling
breathability
properties,
making
RSH-based
IEC
well-suited
applications
where
exposure
environmental
gas
liquid
contaminants
likely.
approach
provides
another
avenue
towards
flexible
integrated
electronics,
opening
up
possibilities
advancement
field.
JACS Au,
Год журнала:
2023,
Номер
3(2), С. 344 - 357
Опубликована: Янв. 26, 2023
Design
of
the
next-generation
therapeutics,
biosensors,
and
molecular
tools
for
basic
research
requires
that
we
bring
protein
activity
under
control.
Each
has
unique
properties,
therefore,
it
is
critical
to
tailor
current
techniques
develop
new
regulatory
methods
regulate
proteins
interest
(POIs).
This
perspective
gives
an
overview
widely
used
stimuli
synthetic
natural
conditional
regulation
proteins.
