Direct synthesis of alkylated 4-hydroxycoumarin derivatives via a cascade Cu-catalyzed dehydrogenation/conjugate addition sequence DOI
Zhiliang Chen, Hongyi Li,

Yanjing Liao

и другие.

Chemical Communications, Год журнала: 2023, Номер 59(44), С. 6686 - 6689

Опубликована: Янв. 1, 2023

An efficient approach for the direct synthesis of alkylated 4-hydroxycoumarin derivatives via a Cu-catalyzed cascade dehydrogenation/conjugate addition sequence starting from simple saturated ketones and 4-hydroxycoumarins has been developed. This protocol features excellent functional-group tolerance, easy scale-up, broad substrate scope including bioactive molecules. More importantly, series marketed drugs, such as warfarin, acenocoumarol, coumachlor, coumafuryl, can be obtained by this method.

Язык: Английский

Synthesis of chiral carbocycles via enantioselective β,γ-dehydrogenation DOI
Tao Sheng, Tao Zhang, Zhe Zhuang

и другие.

Nature Synthesis, Год журнала: 2024, Номер 3(12), С. 1550 - 1559

Опубликована: Авг. 15, 2024

Язык: Английский

Процитировано

4
Synthesis of bicyclo[3.2.0]heptane lactones via a ligand-enabled Pd-catalyzed C(sp3)–H activation cascade DOI Creative Commons
Zhoulong Fan, Xinpei Cai, Tao Sheng

и другие.

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Bicyclo[3.2.0]heptane lactones represent an important scaffold in bioactive molecules. Herein, we report a diastereoselective synthetic disconnection to access bicyclo[3.2.0]heptane from bicyclo[1.1.1]pentane carboxylic acids, which proceeds through palladium-catalyzed C-H activation and C-C cleavage processes. By using two different classes of ligands, MPAA pyridone-amine, either all-syn arylated or non-arylated ones can be synthesized. The lactone products were converted into multiple substituted cyclobutane, γ-lactone, oxobicyclo[3.2.0]heptane derivatives showcase the versatility this method.

Язык: Английский

Процитировано

0
Modifications of Terpenoids via Inert Aliphatic C−H Bonds Heteroarylation with Heteroarenes DOI

Shuxin Yang,

Huirong Li,

Jiaxing Lv

и другие.

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A method to modify commercially available terpenoids via inert aliphatic C–H bond heteroarylation directly with heteroarenes catalyzed by decatungstate anion is developed.

Язык: Английский

Процитировано

0
Synthesis of lactones and lactams via C(sp3)–H bond functionalization DOI

E. Premkumar,

Ramdas Sreedharan,

Premananda Ghosh

и другие.

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

In this review, we have showcased the diverse aspects of transition-metal catalysis, biocatalysis, and photocatalytic C(sp 3 )–H bond functionalization to access lactones lactams.

Язык: Английский

Процитировано

0
Direct synthesis of alkylated 4-hydroxycoumarin derivatives via a cascade Cu-catalyzed dehydrogenation/conjugate addition sequence DOI
Zhiliang Chen, Hongyi Li,

Yanjing Liao

и другие.

Chemical Communications, Год журнала: 2023, Номер 59(44), С. 6686 - 6689

Опубликована: Янв. 1, 2023

An efficient approach for the direct synthesis of alkylated 4-hydroxycoumarin derivatives via a Cu-catalyzed cascade dehydrogenation/conjugate addition sequence starting from simple saturated ketones and 4-hydroxycoumarins has been developed. This protocol features excellent functional-group tolerance, easy scale-up, broad substrate scope including bioactive molecules. More importantly, series marketed drugs, such as warfarin, acenocoumarol, coumachlor, coumafuryl, can be obtained by this method.

Язык: Английский

Процитировано

8