Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(8)
Опубликована: Ноя. 21, 2023
Nanomedicines
are
extensively
used
in
cancer
therapy.
Covalent
organic
frameworks
(COFs)
crystalline
porous
materials
with
several
benefits
for
therapy,
including
porosity,
design
flexibility,
functionalizability,
and
biocompatibility.
This
review
examines
the
use
of
COFs
therapy
from
perspective
reticular
chemistry
function-oriented
design.
First,
modification
sites
functionalization
methods
discussed,
followed
by
their
potential
as
multifunctional
nanoplatforms
tumor
targeting,
imaging,
integrating
functional
components.
Finally,
some
challenges
clinical
translation
presented
hope
promoting
development
COF-based
anticancer
nanomedicines
bringing
closer
to
trials.
Metal–organic
frameworks
(MOFs)
have
garnered
significant
attention
in
the
field
of
catalysis
due
to
their
unique
advantages
such
as
diverse
coordination
geometry,
variable
metal
nodes,
and
organic
linkers,
facilitating
precise
structural
compositional
control
for
achieving
programmable
catalytic
functionalities.
Although
inherent
microporous
structure
could
provide
excellent
shape
selectivity
during
catalysis,
it
typically
impedes
mass
transfer
process,
thereby
reducing
use
internal
active
sites
overall
efficiency.
Additionally,
employing
single
MOFs
catalysts
presents
challenges
complex
reactions
that
require
multifunctional
sites.
In
recent
years,
considerable
research
efforts
focused
on
designing
constructing
hierarchical
nanostructured
alleviate
substrate
diffusion
limitations
by
introducing
secondary
nanopores,
shortening
distances
via
construction
low-dimensional
nanoarchitectures,
integrating
distinct
with
suitable
functions.
This
review
provides
a
comprehensive
overview
design,
synthesis
methods,
formation
mechanisms
MOF-based
nanostructures
years.
Subsequently,
further
highlights
applications
thermal
electrocatalysis,
photocatalysis,
along
relationship
between
performances.
Finally,
an
outlook
potential
development
directions
hierarchically
structured
MOF
nanocatalysts.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 27, 2024
Abstract
The
interlayer
stacking
modes
of
2D
covalent‐organic
frameworks
(COFs)
directly
influence
their
structural
features,
ultimately
determining
functional
output.
However,
controllably
modulating
the
structure
in
traditional
metal‐free
COFs,
based
on
same
building
blocks,
remains
challenging.
Here,
two
trinuclear
copper
organic
are
synthesized
successfully
with
different
structures:
eclipsed
AA
Cu
3
‐PA‐COF‐AA
and
staggered
ABC
‐PA‐COF‐ABC,
using
monomers.
Remarkably,
various
functionalities,
including
porosity
electronic
optical
properties,
can
be
effectively
regulated
by
stacking.
As
a
result,
‐PA‐COF‐ABC
exhibit
significantly
activities
toward
photoreduction
U(VI),
presenting
promising
strategy
for
removing
radioactive
uranium
pollution.
Due
to
its
broader
visible‐light
absorption
range
superior
photogenerated
carrier
migration
separation
efficiency,
achieves
U(VI)
removal
ratio
93.6%
without
additional
sacrificial
agents
an
air
atmosphere—≈2.2
times
higher
than
that
(42.0%).
To
best
knowledge,
this
is
first
study
elucidate
effect
COFs
photocatalytic
activity
reduction.
This
finding
may
inspire
further
exploration
structure‐function
relationship
as
photocatalysts
potential
photoinduced
radionuclides.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
62(9)
Опубликована: Дек. 27, 2022
The
synthesis
of
atomically
precise
copper
nanoclusters
(Cu-NCs)
with
high
chemical
stability
is
a
prerequisite
for
practical
applications,
yet
still
remains
long-standing
challenge.
Herein,
we
have
prepared
pyrazolate-protected
Cu-NC
(Cu8),
which
exhibited
exceptional
either
in
solid-state
or
solution.
crystals
Cu8
are
suitable
single
crystal
X-ray
diffraction
analysis
even
after
being
treated
boiling
water,
8
wt
%
H2
O2
,
concentrated
acid
(1
M
HCl)
saturated
base
(≈20
KOH),
respectively.
More
importantly,
the
structure
solution
also
remained
intact
toward
oxygen,
organic
(100
eq.
HOAc)
(400
dibutylamine)
confirmed
by
1
H
NMR
and
UV/Vis
analysis.
Taking
advantage
alkali-resistant,
illustrates
excellent
catalytic
activity
indolizines,
it
can
be
reused
at
least
10
cycles
without
losing
performance.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(8)
Опубликована: Ноя. 21, 2023
Nanomedicines
are
extensively
used
in
cancer
therapy.
Covalent
organic
frameworks
(COFs)
crystalline
porous
materials
with
several
benefits
for
therapy,
including
porosity,
design
flexibility,
functionalizability,
and
biocompatibility.
This
review
examines
the
use
of
COFs
therapy
from
perspective
reticular
chemistry
function-oriented
design.
First,
modification
sites
functionalization
methods
discussed,
followed
by
their
potential
as
multifunctional
nanoplatforms
tumor
targeting,
imaging,
integrating
functional
components.
Finally,
some
challenges
clinical
translation
presented
hope
promoting
development
COF-based
anticancer
nanomedicines
bringing
closer
to
trials.
