Chinese Chemical Letters, Год журнала: 2023, Номер 34(11), С. 108594 - 108594
Опубликована: Май 19, 2023
Язык: Английский
Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417
Опубликована: Янв. 1, 2023
Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.
Язык: Английский
Процитировано
148
Coordination Chemistry Reviews, Год журнала: 2023, Номер 501, С. 215560 - 215560
Опубликована: Ноя. 27, 2023
Язык: Английский
Процитировано
60
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)
Опубликована: Май 16, 2024
Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain
Язык: Английский
Процитировано
26
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Авг. 29, 2024
Thermoelectric technology has recently emerged as a distinct therapeutic modality. However, its effectiveness is significantly limited by the restricted temperature gradient within living organisms. In this study, we introduce high-performance plasmonic-thermoelectric catalytic therapy utilizing urchin-like Cu
Язык: Английский
Процитировано
26
Chemical Society Reviews, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The past decades have witnessed great strides in phototherapy as an experimental option or regulation-approved treatment numerous cancer indications.
Язык: Английский
Процитировано
19
Light Science & Applications, Год журнала: 2025, Номер 14(1)
Опубликована: Янв. 2, 2025
Abstract The microenvironment of immunosuppression and low immunogenicity tumor cells has led to unsatisfactory therapeutic effects the currently developed nanoplatforms. Immunogenic cell death, such as pyroptosis ferroptosis, can efficiently boost antitumor immunity. However, exploration nanoplatform for dual function inducers combined immune activators that simultaneously trigger ferroptosis remains limited. Herein, a multifunctional pH-responsive theranostic (M@P) is designed constructed by self-assembly aggregation-induced emission photosensitizer MTCN-3 immunoadjuvant Poly(I: C), which are further encapsulated in amphiphilic polymers. This found have characteristics cancer targeting, pH response, near-infrared fluorescence imaging, lysosome targeting. Therefore, after targeting lysosomes, M@P cause dysfunction through generation reactive oxygen species heat under light irradiation, triggering cells, achieving immunogenic enhancing immunotherapy effect with C). anti-tumor been demonstrated vivo experiment 4T1 tumor-bearing mouse model poor immunogenicity. research would provide an impetus well novel strategy enhanced photoimmunotherapy.
Язык: Английский
Процитировано
8
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Aggregation profoundly influences the photophysical properties of molecules. Here, a new series thiopyrylium-based hemicyanine near-infrared II (NIR-II) fluorophores is developed by meticulously adjusting their aggregation states. Notably, star molecule HTPA exhibits remarkable pH-responsive behavior and significant increase in photoacoustic (PA) intensity when aggregated. Additionally, pH reversibility during formation are systematically investigated, including computational optimization, femtosecond transient absorption spectroscopy, NMR analysis, single crystal analysis. Finally, an innovative "off " nanoparticle specifically designed for effective tumor-targeted PA/NIR-II dual-modal imaging photodynamic therapy utilizing polymer. The signal-to-background ratio (SBR) PA signals significantly increased to 169 region interest (ROI) mouse model irradiated at 1064 nm. These findings not only provide promising avenue future studies NIR-II small molecules but also pave way advances field integrated cancer diagnosis therapy.
Язык: Английский
Процитировано
4
Nature Nanotechnology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
3
Analytical Chemistry, Год журнала: 2023, Номер 95(25), С. 9404 - 9408
Опубликована: Июнь 12, 2023
Caspase-3 is an essential executor in apoptosis, and its activation has been regarded as a biomarker of cell apoptosis. The development Caspase-3-responsive multimodal probes promising research prospect. Fluorescent/photoacoustic (FL/PA) imaging attracted considerable attention due to the high sensitivity FL well spatial resolution penetration depth PA. To our knowledge, there no tumor-targeted FL/PA probe monitor activity vivo. Therefore, we developed (Bio-DEVD-HCy) for tumor Ac-DEVD-HCy without biotin used control probe. In vitro experiments indicated that Bio-DEVD-HCy superior because higher kinetic parameter comparison Ac-DEVD-HCy. Cell results suggested could enter accumulate cells with signal help biotin. detail, or image apoptotic 4.3-fold 3.5-fold enhancement 3.4-fold 1.5-fold PA enhancement. apoptosis 2.5-fold 1.6-fold 4.1-fold 1.9-fold We envision will be applied clinical settings.
Язык: Английский
Процитировано
38
Analytical Chemistry, Год журнала: 2023, Номер 95(28), С. 10481 - 10485
Опубликована: Июль 3, 2023
β-Galactosidase (β-gal) is the gold standard marker of cellular senescence, which linked with various age-related diseases. Therefore, it essential to develop more excellent probes that can real-time monitor β-gal activity in senescence vivo. Fluorescent/photoacoustic (FL/PA) dual-modal imaging possesses sensitivity and spatial resolution. To our knowledge, there has been no tumor-targeted FL/PA probe image by monitoring we developed a (Gal-HCy-Biotin) for β-gal-activatable tumor senescence. Gal-HCy without biotin used as control probe. Gal-HCy-Biotin superior due higher kinetic parameter than vitro. Moreover, could help enter accumulate cells signal. In detail, or senescent 4.6-fold 3.5-fold FL enhancement 4.1-fold 3.3-fold PA enhancement. 2.9-fold 1.7-fold 3.8-fold 1.3-fold We envision will be applied clinic.
Язык: Английский
Процитировано
28