Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

---

Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215560 - 215560

Published: Nov. 27, 2023

Language: Английский

---

A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 29, 2024

Thermoelectric technology has recently emerged as a distinct therapeutic modality. However, its effectiveness is significantly limited by the restricted temperature gradient within living organisms. In this study, we introduce high-performance plasmonic-thermoelectric catalytic therapy utilizing urchin-like Cu

Language: Английский

---

A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy

Light Science & Applications, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 2, 2025

Abstract The microenvironment of immunosuppression and low immunogenicity tumor cells has led to unsatisfactory therapeutic effects the currently developed nanoplatforms. Immunogenic cell death, such as pyroptosis ferroptosis, can efficiently boost antitumor immunity. However, exploration nanoplatform for dual function inducers combined immune activators that simultaneously trigger ferroptosis remains limited. Herein, a multifunctional pH-responsive theranostic (M@P) is designed constructed by self-assembly aggregation-induced emission photosensitizer MTCN-3 immunoadjuvant Poly(I: C), which are further encapsulated in amphiphilic polymers. This found have characteristics cancer targeting, pH response, near-infrared fluorescence imaging, lysosome targeting. Therefore, after targeting lysosomes, M@P cause dysfunction through generation reactive oxygen species heat under light irradiation, triggering cells, achieving immunogenic enhancing immunotherapy effect with C). anti-tumor been demonstrated vivo experiment 4T1 tumor-bearing mouse model poor immunogenicity. research would provide an impetus well novel strategy enhanced photoimmunotherapy.

Language: Английский

---

Applications and Enhancement Strategies of ROS-based Non-invasive Therapies in Cancer Treatment

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515

Published: Jan. 1, 2025

Language: Английский

---

Aggregation‐Mediated Photoacoustic/NIR‐II and Photodynamic Properties of pH‐Reversible Thiopyrylium Agents: A Computational and Experimental Approach

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Aggregation profoundly influences the photophysical properties of molecules. Here, a new series thiopyrylium-based hemicyanine near-infrared II (NIR-II) fluorophores is developed by meticulously adjusting their aggregation states. Notably, star molecule HTPA exhibits remarkable pH-responsive behavior and significant increase in photoacoustic (PA) intensity when aggregated. Additionally, pH reversibility during formation are systematically investigated, including computational optimization, femtosecond transient absorption spectroscopy, NMR analysis, single crystal analysis. Finally, an innovative "off " nanoparticle specifically designed for effective tumor-targeted PA/NIR-II dual-modal imaging photodynamic therapy utilizing polymer. The signal-to-background ratio (SBR) PA signals significantly increased to 169 region interest (ROI) mouse model irradiated at 1064 nm. These findings not only provide promising avenue future studies NIR-II small molecules but also pave way advances field integrated cancer diagnosis therapy.

Language: Английский

---

Caspase-3-Responsive Fluorescent/Photoacoustic Imaging of Tumor Apoptosis

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(25), P. 9404 - 9408

Published: June 12, 2023

Caspase-3 is an essential executor in apoptosis, and its activation has been regarded as a biomarker of cell apoptosis. The development Caspase-3-responsive multimodal probes promising research prospect. Fluorescent/photoacoustic (FL/PA) imaging attracted considerable attention due to the high sensitivity FL well spatial resolution penetration depth PA. To our knowledge, there no tumor-targeted FL/PA probe monitor activity vivo. Therefore, we developed (Bio-DEVD-HCy) for tumor Ac-DEVD-HCy without biotin used control probe. In vitro experiments indicated that Bio-DEVD-HCy superior because higher kinetic parameter comparison Ac-DEVD-HCy. Cell results suggested could enter accumulate cells with signal help biotin. detail, or image apoptotic 4.3-fold 3.5-fold enhancement 3.4-fold 1.5-fold PA enhancement. apoptosis 2.5-fold 1.6-fold 4.1-fold 1.9-fold We envision will be applied clinical settings.

Language: Английский

---

β-Galactosidase-Activatable Fluorescent and Photoacoustic Imaging of Tumor Senescence

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(28), P. 10481 - 10485

Published: July 3, 2023

β-Galactosidase (β-gal) is the gold standard marker of cellular senescence, which linked with various age-related diseases. Therefore, it essential to develop more excellent probes that can real-time monitor β-gal activity in senescence vivo. Fluorescent/photoacoustic (FL/PA) dual-modal imaging possesses sensitivity and spatial resolution. To our knowledge, there has been no tumor-targeted FL/PA probe image by monitoring we developed a (Gal-HCy-Biotin) for β-gal-activatable tumor senescence. Gal-HCy without biotin used as control probe. Gal-HCy-Biotin superior due higher kinetic parameter than vitro. Moreover, could help enter accumulate cells signal. In detail, or senescent 4.6-fold 3.5-fold FL enhancement 4.1-fold 3.3-fold PA enhancement. 2.9-fold 1.7-fold 3.8-fold 1.3-fold We envision will be applied clinic.

Language: Английский

---

Superoxide Anion-Mediated Afterglow Mechanism-Based Water-Soluble Zwitterion Dye Achieving Renal-Failure Mice Detection

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(49), P. 26736 - 26746

Published: Nov. 28, 2023

Afterglow materials-based biological imaging has promising application prospects, due to negligible background. However, currently available afterglow materials mainly include inorganic as well some organic nanoparticles, which are difficult translate the clinic, resulting from non-negligible metabolic toxicity and even leakage risk of heavy metals. Although building small molecules could solve such obstacles, with ability extremely scarce, especially a sufficient renal capacity. To address these issues, herein, we designed water-soluble zwitterion Cy5-NF capacity luminescence, relied on an intramolecular cascade reaction between superoxide anion (O2•–, instead 1O2) release luminescence. Of note, compared different reference contrast agents, not only had excellent properties but also rapid metabolism rate (half-life period, t1/2, around 10 min) good biocompatibility. Unlike prior nanosystems possessing large size, for first time, achieved construction showed higher sensitivity signal-to-background ratio in than fluorescence kidney. Moreover, longer kidney retention time renal-failure mice (t1/2 more 15 min). More importantly, can be metabolized very quickly severe 25–30 min), greatly improved biosecurity. Therefore, optimistic that O2•–-mediated mechanism-based is clinical application, detection failure.

Language: Английский

---

Chiral CuxOS@Fe‐MOFs for Enhanced Cancer Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(10)

Published: Nov. 29, 2023

Abstract Here, the development of chiral D ‐/ L ‐Cu x OS nanoparticle‐engineered metal–organic frameworks (Fe‐MIL‐88B‐NH 2 ), denoted as OS@Fe‐MOFs, for cuproptosis and ferroptosis synergistic therapy is described. The OS@Fe‐MOF displayed intense circular dichroism (CD) bands at 488 nm due to chirality transfer from penicillamine ligands. Chiral showed tumor microenvironment‐triggered catalytic therapeutic activity by simultaneously depleting ‐glutathione (GSH) generating potent reactive oxygen species in cancer cells. In vivo experimental results synchronously demonstrated with higher efficiency therapy. findings revealed that copper/iron ions released induced augmented oxidative stress ferroptosis, which synergizes enhanced index determined be 1.94, while D,L 1.75 1.84, respectively. To best knowledge, this first report a nanomaterial capable inducing ferroptosis‐cuproptosis cancers. should invigorate studies pursuing rational design nanomaterials efficacious based on ferroptosis.

Language: Английский

---