European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117587 - 117587
Опубликована: Март 1, 2025
Язык: Английский
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(29), С. 19609 - 19620
Опубликована: Июль 11, 2024
Azobenzenes (Ph-N═N-Ph) are known as the most widely studied molecular photoswitches, and recent rise of azoheteroarenes (Het-N═N-Ph or Het-N═N-Het) offers great opportunities to advance this already mature field. A common limitation is that azo-switches generally require harmful UV light for activation, which hinders their application across various fields. Despite efforts in developing visible-light azobenzenes over past few decades, potential heteroaryl azoswitches remains largely unexplored. This Perspective summarizes state-of-the-art advancements azoswitches, covering design strategies, structure-property relationship, applications. We highlight distinctive advantages research development switches. Furthermore, we discuss challenges emerging field propose solutions address crucial issues such spectral red-shift thermal half-life. Through paper, aim provide inspiration further exploration field, anticipation growing prosperity bright future azoheteroarene photoswitches.
Язык: Английский
Процитировано
29
Advanced Functional Materials, Год журнала: 2024, Номер 34(24)
Опубликована: Фев. 21, 2024
Abstract Photochromic materials have drawn enormous attention for their potential applications in optical memory storage and photoswitchable molecular devices. Although great achievements photochromic been fulfilled, it is still a big challenge to realize gated photochromism ready tunable properties. In previous studies, rare examples of are reported. Herein, three triarylethylene derivatives FTrPE‐ o I, ClTrPE‐ I BrTrPE‐ with reversible thermally activated characteristics designed synthesized, whose crystalline powders show no until treatments relative temperature. Temperature acts as gate switch the properties by switching aggregation state from melted amorphous. With this progress, broader structural realm becomes accessible materials, which can now be synthetically tailored advanced future applications, e.g., research on machines switches, studies photoisomerization mechanisms, or generation thermal tracing materials. To showcase these distinct encrypted printing, trace monitoring well multi‐level anticounterfeiting demonstrated, addition comprehensive photochemical study all compounds.
Язык: Английский
Процитировано
28
Journal of the American Chemical Society, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Molecular photoswitch research has drawn much attention in the last century owing to its great potential development of smart materials. However, photoswitches suitable for constructing light-responsive luminescent materials remain limited, especially those involving triplet-state phosphorescence. Herein, we designed a novel molecular based on conformation transition phenothiazine derivatives, minimizing steric hindrance (-CH
Язык: Английский
Процитировано
5
Progress in Polymer Science, Год журнала: 2023, Номер 149, С. 101782 - 101782
Опубликована: Дек. 27, 2023
Язык: Английский
Процитировано
28
Polymer Journal, Год журнала: 2024, Номер unknown
Опубликована: Янв. 16, 2024
Abstract Photoinduced transitions between the solid, glass, and liquid states based on molecular photoswitches promise a wide variety of applications. Photoswitchable adhesives are representative examples expected to contribute material recycling for sustainable future in era composite materials due strong bonding on-demand photo-induced debonding with minimal damage adherends. Only few known undergo these transitions, but recent progress, mainly azobenzene, has been remarkable. Here, we review photoinduced small molecules polymers over approximately decade systematically discuss designs, mechanisms, applications, merits demerits, challenges each photoswitch whole field. We hope this provides useful information, inspiration, ideas development field expansion its
Язык: Английский
Процитировано
13
Medicinal Research Reviews, Год журнала: 2025, Номер unknown
Опубликована: Март 6, 2025
The use of photoswitchable ligand to control the protein functionalities and related downstream effects in an on-off manner is active research area photopharmacology medicinal chemistry. Temporal grants a privilege identify crucial role particular receptor biological occurrences without destroying permanently. Additionally, light can be applied site-selectively regulate functionality with cellular sub-cellular levels spatial resolutions. spatiotemporal resolution enables probing specific receptor, isoform, or signalling pathway. This reversible fast highly beneficial studying dynamic processes, including but not limited signal transduction, neurotransmission, cell divisions, immune response, folding, degradation. Though several light-active ligands have been developed efficiently, only few reports on exist literature. Major challenges achieve efficient photoswitches study are synthesis strategy, photostability ligand, bidirectional visible switching ability most importantly precise controlling local concentration desired photoisomer using light. site-specific localization depends multiple factors like nature photoswitch, binding affinity both photoisomers, molecular diffusion irradiation conditions. present review discusses suitable techniques different achieving subcellular dimension functionality. Multiple strategies discussed, along their advantages limitations, explore enormous potentiality these approaches manipulating
Язык: Английский
Процитировано
1
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(49)
Опубликована: Июнь 3, 2023
The cannabinoid 2 receptor (CB2 R) has high therapeutic potential for multiple pathogenic processes, such as neuroinflammation. Pathway-selective ligands are needed to overcome the lack of clinical success and elucidate correlations between pathways their respective effects. Herein, we report design synthesis a photoswitchable scaffold based on privileged structure benzimidazole its application functionally selective CB2 R "efficacy-switch". Benzimidazole azo-arenes offer huge broad extension photopharmacology wide range optically addressable biological targets. We used this develop compound 10 d, "trans-on" agonist, which serves molecular probe study β-arrestin2 (βarr2) pathway at R. βΑrr2 bias was observed in internalization βarr2 recruitment, while no activation occurred when looking Gα16 or mini-Gαi . Overall, d is first light-dependent agonist investigate complex mechanisms R-βarr2 dependent endocytosis.
Язык: Английский
Процитировано
21
Journal of Materials Chemistry C, Год журнала: 2024, Номер 12(11), С. 3811 - 3837
Опубликована: Янв. 1, 2024
Machine learning can predict the properties of phase change azobenzene derivatives and guide molecular design to further improve their photothermal conversion performance.
Язык: Английский
Процитировано
9
Chemical Science, Год журнала: 2024, Номер 15(14), С. 5360 - 5367
Опубликована: Янв. 1, 2024
Arylazobenzimidazoles are photoswitchable privileged structures in medicinal chemistry. Experimental and theoretical studies identified compounds with visible light near-quantitative bidirectional photoswitching highly tunable Z -isomer stability.
Язык: Английский
Процитировано
9
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 7, 2024
Azo switches are widely employed as essential components in light-responsive systems. Here, we develop an azo-fluorescent switch that is visible and its processes can be monitored using fluorescence imaging. Visible light irradiation promotes isomerization, accompanied by changes enable the process to through Furthermore, document nanocavity size of liposome encapsulated nanoparticles containing azo isomerization show this change enables construction a nanoplatform for optically controlled release antimycotics. Also, natural activation loaded with antimycotic agent causes death Rhizoctonia solani. The results these double holding period comparison small molecule strategy used design imaging-guided light-controlled nano-antimycotic system applicable protocols delivery wide variety drugs.
Язык: Английский
Процитировано
8