ACS Applied Nano Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 27, 2023
Drugs
emerge
in
an
endless
stream;
the
global
drug
supply
is
increasing,
and
number
of
users
steadily
rising,
so
detection
acetic
anhydride,
a
raw
material
for
preparation,
great
significance
controlling
spread
drugs.
The
crystal
phase
semiconductor
metal
oxides
has
important
impact
on
oxygen
vacancy,
microscopic
morphology,
specific
surface
area,
high-energy
exposure,
which
turn
affect
catalytic
gas-sensing
effects
materials.
Ion
doping
can
sometimes
achieve
purpose
changing
phase.
In
this
study,
Cd-doped
biphase
(cubic
hexagonal
phase)
In2O3
nanospheres
sensitive
to
anhydride
were
synthesized
via
one
easy
hydrothermal
process
proportion
cubic
controlled
by
amount
Cd
element.
ion-doped
structure
save
consumption
expensive
metals
provide
heterojunction
as
well
more
vacancy
enhance
gas
sensing
properties.
fabricated
sensors
not
only
have
high
sensitivity
(372)
100
ppm
dry
environment
220
°C
but
also
keep
excellent
selectivity
good
stability.
X-ray
diffraction
(XRD),
energy
dispersive
spectroscopy
(EDS)
analysis,
scanning
electron
microscopy
(SEM),
photoelectron
(XPS)
used
observe
phase,
elemental
information,
nanoscale
appearance,
existing
state
elements
prepared
compounds.
gas-sensitive
mechanism
was
briefly
analyzed
according
characterization
information.
enhancing
properties
are
owing
change
internal
electronic
channels,
abundant
caused
doping.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Transition
metal-catalyzed
carbonylative
coupling
reactions
play
a
crucial
role
in
the
synthesis
of
functional
molecules
use
throughout
pharmaceutical
development,
natural
products,
and
material
science.1,2
This
utility
is
driven
by
both
efficiency
carbonylation
chemistry
broad
presence
carbonyl
functionality
most
synthetic
materials.
Unfortunately,
development
enantioselective
to
access
α-chiral
motif
found
drugs
date
not
viable.
has
been
attributed
inhibitory
influence
carbon
monoxide,
which
blocks
activation
pro-chiral
alkyl
halides
limits
efficacy
chiral
ligand
environments
modulating
selectivity.
Here
we
show
how
this
challenge
can
be
addressed
via
conceptually
alternative
approach
such
reactions,
where
photoredox
nickel
catalysis
employed
separate
reactivity
from
stereocontrol.
combined
strategy
enabled
first
asymmetric
C(sp3)
organic
preparation
diverse
array
amides
with
excellent
enantioselectivity.
These
findings
expand
scope
offer
new
possibilities
for
synthesizing
carbonyl-containing
compounds
wide-ranging
implications
drug
discovery
chemistry.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
1,2-Amino-difunctionalization
reactions
of
alkenes
allow
the
efficient
introduction
different
functional
groups
and
rapid
construction
valuable
functionalized
amines.
In
this
respect,
we
report
a
copper-catalyzed
1,2-amino-alkoxycarbonylation
unactivated
with
CO
alkylamine
precursors
in
presence
Lewis
acid
additive.
The
novel
protocol
allows
direct
access
to
β-amino
derivatives
from
easily
available
starting
materials.
presented
methods
feature
high
chemo-
regioselectivities,
good
group
tolerance,
substrate
scope
including
diverse
bioactive
compounds
drug-like
molecules.
Mechanistic
studies
indicate
that
additive
is
key
realizing
umpolung
addition
nucleophilic
aminyl
radicals
electron-rich
alkenes,
which
represents
an
elegant
activation
strategy
for
radicals.
JACS Au,
Год журнала:
2025,
Номер
5(3), С. 1413 - 1420
Опубликована: Март 5, 2025
Accessing
unsymmetric
ketones
and
achieving
their
carbon
isotope
labeling
are
crucial
yet
challenging
tasks
in
both
synthetic
medicinal
chemistry.
We
report
here
an
efficient
electrochemical
nickel-/cobalt-catalyzed
carbonylative
cross-electrophile
coupling
reaction.
This
method
allows
for
the
modular
synthesis
of
a
library
from
simple
building
blocks,
including
aryl
halides,
alkyl
gaseous
CO.
The
simultaneous
use
nickel
cobalt
salts
as
concerted
catalysts
ensures
high
efficiency
this
three-component
coupling.
Furthermore,
reduction
avoids
stoichiometric
reductants,
making
protocol
more
sustainable
attractive.
broad
substrate
scope
late-stage
13C
complex
molecules
derived
biologically
active
compounds
highlight
practicality
method.
Organic Chemistry Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Radical
transnitrilation
of
arylborons
via
a
mild
copper
catalysis
was
developed,
featuring
broad
scope,
high
functionality
tolerance,
scalability
and
practicality.
Organic Letters,
Год журнала:
2024,
Номер
26(15), С. 3299 - 3303
Опубликована: Март 28, 2024
Acyl
fluorides
are
important
reagents
due
to
their
unique
balance
between
reactivity
and
stability.
Here,
we
report
a
copper-catalyzed
carbonylative
coupling
strategy
for
synthesizing
acyl
under
photoirradiation.
Alkyl
iodides
were
transformed
in
high
yields
into
by
using
commercially
available
copper
precatalyst
(CuBr·SMe2)
readily
fluoride
salt
(KF)
at
ambient
temperature
mild
CO
pressure
(6
atm)
blue
light
irradiation.
