Catalysts,
Год журнала:
2024,
Номер
14(4), С. 219 - 219
Опубликована: Март 22, 2024
In
the
past
few
decades,
N-heterocyclic
carbenes
(NHCs)
have
opened
new
field
of
organocatalysis
in
synthetic
organic
chemistry.
This
review
highlights
dramatic
progress
NHC-catalyzed
C–O
bond
formation
based
on
activation
aldehyde
C(sp2)–H
bonds.
The
oxidative
and
redox
transformations
for
synthesis
various
molecules
with
structural
diversity
complexity
are
summarized.
Furthermore,
methods
strategies
NHC
catalysis
emerging
continuously;
thus,
cooperative
Brønsted
acid,
hydrogen-bonding
catalyst,
transition-metal
photocatalyst
also
described.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Comprehensive
Summary
An
amide‐substituted
quinuclidine‐borane
has
been
identified
as
a
more
efficient
hydridic
hydrogen
atom
transfer
(HAT)
catalyst
for
the
hydroalkylation
of
unactivated
olefins
under
visible‐light
irradiation.
1
H
NMR
titration
experiments
reveal
that
amide
moiety
forms
stronger
bonds
with
carbonyl
substrates,
thereby
improving
reaction
yields.
Furthermore,
it
was
found
yields
correlate
well
association
constant
between
and
substrate.
A
scale‐up
using
continuous‐flow
photoreactor
also
demonstrated.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
The
direct
enantioselective
functionalization
of
C(sp3)–H
bonds
in
organic
molecules
could
fundamentally
transform
the
synthesis
chiral
molecules.
In
particular,
oxidation
these
would
dramatically
change
production
methods
alcohols
and
esters,
which
are
prevalent
natural
products,
pharmaceuticals,
fine
chemicals.
Remarkable
advances
have
been
made
construction
carbon–carbon
carbon–nitrogen
through
bond
functionalization.
However,
formation
carbon–oxygen
from
remains
a
considerable
challenge.
We
herein
report
highly
oxidative
coupling
with
carboxylic
acids.
method
applies
to
allylic
propargylic
C–H
employs
various
acids
as
oxygenating
agents.
successfully
synthesized
range
esters
directly
readily
available
alkenes
alkynes,
greatly
simplifying
related
alcohols.
Abstract
Nitrogen‐containing
heterocycles
represent
fundamental
components
found
in
a
myriad
of
natural
compounds,
pharmaceuticals,
tailored
bioactive
substances,
and
agrochemicals.
In
recent
decades,
the
field
synthetic
chemistry
has
prioritized
these
directing
considerable
research
endeavour
toward
developing
efficient
concise
methodologies
for
their
synthesis.
Consequently,
there
is
growing
interest
pioneering
novel
approaches
to
fabricate
immensely
coveted
structural
motifs.
Transition
metal‐catalyzed
reactions
leveraging
solvents
as
carbon
(C1)
synthons
offer
notable
advantages,
including
streamlined
processes,
enhanced
atom
economy,
environmental
sustainability.
This
review
sheds
light
on
advancements
utilization
collective
such
methanol
(alongside
other
alcohols),
N,N
‐dimethylethanolamine
(DMEA),
triethylamine
(TEA)
(in
conjunction
with
amines),
tetrahydrofuran
(THF),
toluene,
dichloromethane
(DCM),
dimethyl
sulfoxide
(DMSO),
dimethylformamide
(DMF)
C1
synthons,
serving
foundational
units
synthesis
N
‐heterocycles,
quinazolinone,
quinazoline,
quinoxaline,
pyridine,
pyrimidine,
among
others.
Various
reaction
conditions
employing
diverse
transition
metals,
coupling
partners,
or
reagents,
reported
literature,
have
been
explored.
In
the
past
few
decades,
N-heterocyclic
carbenes
(NHCs)
open
new
field
of
organocatalysis
in
synthetic
organic
chemistry.
This
review
highlights
dramatic
progress
NHC-catalyzed
C−O
bond
formation
based
on
activation
aldehyde
C(sp2)−H
bonds.
The
oxidative
and
redox
transformations
for
synthesis
various
molecules
with
structural
diversity
complexity
are
summarized.
Furthermore,
methods
strategies
NHC
catalysis
emerging
continuously;
thus,
cooperative
Brønsted
acid,
hydrogen-bonding
catalyst,
transition-metal
photocatalyst
is
also
described.
Catalysts,
Год журнала:
2024,
Номер
14(4), С. 219 - 219
Опубликована: Март 22, 2024
In
the
past
few
decades,
N-heterocyclic
carbenes
(NHCs)
have
opened
new
field
of
organocatalysis
in
synthetic
organic
chemistry.
This
review
highlights
dramatic
progress
NHC-catalyzed
C–O
bond
formation
based
on
activation
aldehyde
C(sp2)–H
bonds.
The
oxidative
and
redox
transformations
for
synthesis
various
molecules
with
structural
diversity
complexity
are
summarized.
Furthermore,
methods
strategies
NHC
catalysis
emerging
continuously;
thus,
cooperative
Brønsted
acid,
hydrogen-bonding
catalyst,
transition-metal
photocatalyst
also
described.
