Metallaphotoredox
cross-coupling
is
a
well-established
strategy
for
generating
clinically
privileged
aliphatic
scaffolds
via
open-shell
reactivity.
The
introduction
of
new
C(sp3)-coupling
partners
within
this
paradigm
can
provide
entry
to
novel,
medicinally-relevant
chemical
space.
Alkenes
are
abundant,
bench-stable
and
undergo
facile
C(sp3)-radical
reactivity
metal-hydride
hydrogen
atom
transfer
(MHAT),
yet
metallaphotoredox
methodologies
invoking
remain
underdeveloped.
Importantly,
the
merger
MHAT
activation
with
catalysis
could
enable
olefins
feedstock
radical
only
activated
photocatalysis,
such
as
alcohols.
Herein,
we
report
first
C(sp3)–C(sp3)
coupling
MHAT-activated
alkenes
alcohols
(i.e.
deoxygenative
hy-droalkylation)
triple
co-catalysis.
Through
synergistic
Ir
Mn
Ni
sorting
pathways,
branch-selective
protocol
pairs
diverse
methanol
or
primary
alcohols,
displays
remarkable
functional
group
tolerance,
enables
rapid
construction
complex
frameworks.
Organic Letters,
Год журнала:
2024,
Номер
26(18), С. 3796 - 3800
Опубликована: Апрель 30, 2024
The
sulfonylation
method
stands
out
as
a
simple
and
efficient
approach
for
synthesizing
sulfonamides.
Despite
the
advancements
in
constructing
sulfonamide
framework,
potential
use
of
phenyl
hydrazine
an
amination
source
remains
unexplored.
Herein,
we
report
metal-free,
environment-friendly
photoredox-catalyzed
phenylhydrazines
using
thiols,
employing
MeCN:H
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 2, 2025
Unsymmetric
disulfides
are
prevalent
in
natural
products
and
essential
medicinal
chemistry
materials
science,
but
their
robust
synthesis
poses
significant
challenges.
In
this
paper,
we
report
an
expeditous
transition-metal-free
methodology
for
synthesizing
unsymmetric
through
the
addition
of
perthiyl
radicals
to
alkenes.
This
study
marks
use
generating
by
reacting
SO2
with
unactivated
alkyl
(pseudo)halides
(Cl/Br/I/OTs).
Various
primary,
secondary
tertiary
substituted
different
functional
groups
successfully
function
as
suitable
reactants.
The
formation
involvement
reaction
process
verified
mechanistic
studies
DFT
calculations.
Overall,
method
leverages
readily
available
electrophiles
alkenes
alongside
a
single
setup
efficiently
form
both
carbon-sulfur
sulfur-sulfur
bonds
simultaneously.
Here,
authors
novel
transition-metalfree
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
We
report
here
a
metal-free,
redox-neutral
photocatalytic
strategy
of
SO
2
gas
functionalization
resulting
in
the
one-pot
synthesis
sulfonamides,
sulfonate
esters,
and
thiosulfonates
through
photoexcited
phenalenyl
(PLY)
ligand.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
Fluorine
and
nitrogen
form
a
successful
partnership
in
organic
synthesis,
medicinal
chemistry,
material
sciences.
Although
fluorine-nitrogen
chemistry
has
long
rich
history,
this
field
received
increasing
interest
made
remarkable
progress
over
the
past
two
decades,
driven
by
recent
advancements
transition
metal
organocatalysis
photochemistry.
This
review,
emphasizing
contributions
from
2015
to
2023,
aims
update
state
of
art
synthesis
applications
nitrogen-based
organofluorine
functional
molecules
chemistry.
In
dedicated
sections,
we
first
focus
on
fluorine-containing
reagents
organized
according
type
groups
attached
nitrogen,
including
N-F,
N-RF,
N-SRF,
N-ORF.
review
also
covers
nitrogen-linked
building
blocks,
catalysts,
pharmaceuticals,
agrochemicals,
underlining
these
components'
broad
applicability
growing
importance
modern
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(22), С. 6340 - 6346
Опубликована: Янв. 1, 2024
We
developed
the
first
transition-metal-catalyzed,
regiodivergent
sulfonylation
of
aziridines,
enabling
efficient
synthesis
diverse
β-amino
sulfones
under
mild
conditions
with
broad
substrate
compatibility
and
high
regioselectivity.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(21), С. 4263 - 4273
Опубликована: Авг. 28, 2024
Abstract
Aryl
radicals
are
important
intermediates
in
organic
synthesis.
The
generation
of
these
reactive
species
via
direct
decarboxylation
inexpensive
and
readily
available
aromatic
carboxylic
acids
is
an
attractive
goal.
However,
such
a
process
intrinsically
exhibits
high
energy
barriers
to
overcome,
which
consequence
usually
require
precious
metal
catalysis,
stoichiometric
oxidants
harsh
conditions,
suffering
from
limitations
as
poor
functional
group
tolerance
low
atom
economy.
In
recent
years,
photochemical
reactions
have
provided
new
approaches
address
this
challenge.
Three
major
strategies
been
introduced
emerging
field:
1)
one‐pot
in‐situ
activation
benzoic
generate
benzoyl
hypobromites
or
hypoiodites;
2)
the
use
specialized
photocatalysts
like
biphenyl/1,4‐dicyanobenzene
promote
through
photo‐induced
electron
transfer
charge
processes;
3)
LMCT
(Ligand‐to‐Metal
Charge
Transfer)
strategy
where
copper
iron
salts
coordinate
carboxylate
anion
upon
visible
light
excitation.
On
basis
three
strategies,
review
will
systematically
summarize
development
visible‐light‐induced
decarboxylative
functionalization
acids,
focusing
on
reaction
mechanism
substrate
scope,
discuss
their
prospects
