β-C−H bond functionalization of ketones and esters by cationic Pd complexes

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Язык: Английский

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Pd-catalyzed regioselective activation of C(sp²)–H and C(sp³)–H bonds

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Differentiating between two highly similar C-H bonds in a given molecule remains fundamental challenge synthetic organic chemistry. Directing group assisted strategies for the functionalisation of proximal has been known last few decades. However, distal bond is strenuous and requires distinctly specialised techniques. In this review, we summarise advancement Pd-catalysed C(sp

Язык: Английский

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Unified approaches in transition metal catalyzed C(sp³)–H functionalization: recent advances and mechanistic aspects

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Direct alteration of unactivated C–H bonds organic building blocks.

Язык: Английский

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Modular Synthesis of 1,2-Benzothiazines and 1,2-Benzothiazine 1-Imines via Palladium-Catalyzed C–H/C–C Activation Reactions

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(5), С. 3345 - 3358

Опубликована: Фев. 19, 2024

In this study, a modular approach toward cyclic sulfoximines and sulfondiimines via palladium-catalyzed intramolecular C-H/C-C activation reactions was reported. Various 1,2-benzothiazines including bicyclic, tricyclic, highly fused ones, ones of the seven-membered ring, along with 1,2-benzothiazine 1-imines were accessed in good yields. KIE experiment demonstrated that C-H bond cleavage at position

Язык: Английский

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Site‐Selective Distal C(sp3)–H Bromination of Aliphatic Amines as a Gateway for Forging Nitrogen‐Containing sp3 Architectures

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Май 21, 2024

Herein, we disclose a new strategy that rapidly and reliably incorporates bromine atoms at distal, secondary C(sp

Язык: Английский

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Yb-Doped CuY modulates Cu electronic structures for efficient oxidation of anisole to guaiacol

RSC Advances, Год журнала: 2025, Номер 15(13), С. 9899 - 9909

Опубликована: Янв. 1, 2025

Yb-Doped CuY catalysts enhance the electronic structure of copper for efficient hydrogen peroxide oxidation anisole to guaiacol, achieving improved conversion rates and selectivity.

Язык: Английский

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Directed C(sp³)-H Arylation of Free α-Aminophosphonates: Dual Models Exploration via Palladium Catalysis

Organic Letters, Год журнала: 2024, Номер 26(19), С. 4132 - 4136

Опубликована: Май 8, 2024

In this report, we present the dual activation models for transient directing group-directed and amino-self-directed Pd-catalyzed α-aminophosphonate side-chain C(sp3)-H arylation. Both strategies showed facile, efficient, single regioselectivity in reaction between free α-aminophosphonates aryl iodides. Furthermore, modification of amino late-stage functionalization C(sp3)-P bond from products indicates potential applications α-aminophosphonates.

Язык: Английский

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Manganese/Enzyme Sequential Catalytic Pathway for the Production of Optically Active γ-Functionalized Alcohols

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 9103 - 9109

Опубликована: Июнь 6, 2024

A brief, practical catalytic process for the production of optically active γ-functionalized alcohols from relevant alkenes has been developed by using a robust Mn(III)/air/(Me2SiH)2O system combined with lipase-catalyzed kinetic resolution. This approach demonstrates exceptional tolerance toward proximal functional groups present on alkenes, enabling achievement high yields and exclusive enantioselectivity. Under this sequential system, chiral alkene precursors can also be converted into related acetates as separable single enantiomers.

Язык: Английский

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Advances in Transition Metal Catalysis and Organocatalysis Approaches towards Asymmetric Synthesis of β-Amino Acid Derivatives

Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Авг. 16, 2024

Abstract The stereoselective synthesis of β-amino acids has attracted major attention among the synthetic community in recent years. This review provides an overview important advances chiral acid over past decade. It covers development enantioselective methods using transition-metal complexes or organocatalysts, mainly including catalytic asymmetric hydrogenation, Mannich reaction, multicomponent reactions diazo compounds, and conjugate addition. Additionally, optically active by other approaches are also summarized. 1 Introduction 2 Strategies towards Asymmetric Synthesis β-Amino Acids 2.1 Hydrogenation 2.2 Reaction 2.3 Conjugate Addition 2.4 Multicomponent Reactions 2.5 Miscellaneous 2.5.1 from Chiral Amines 2.5.2 Isoxazolidinones 2.5.3 Other Methodologies 3 Summary Outlook

Язык: Английский

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Palladium catalyzed C(sp3)–H bond activation of free carboxylic acids: An adventure of ligand evolution

Tetrahedron Letters, Год журнала: 2024, Номер 138, С. 154951 - 154951

Опубликована: Фев. 7, 2024

Язык: Английский

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