Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 2, 2024
Comprehensive
Summary
Enhancing
the
DNA
toolbox
with
innovative
photochemical
reactions
is
pivotal
for
advancing
nucleic
acid‐based
technologies.
Aldehyde
groups,
versatile
bioorthogonal
handles
imine
formation
under
acidic
conditions,
are
particularly
valuable
due
to
their
roles
in
acid
epigenetics.
Here,
we
present
first
photocatalytic
on‐DNA
aldehyde
allylation,
enabling
precise
functionalization
mild,
neutral
aqueous
conditions.
Our
approach
utilizes
a
polarity‐reversal
reaction
between
DNA‐conjugated
benzaldehydes
and
allyl
sulfones.
This
demonstrates
exceptional
chemoselectivity
while
preserving
integrity.
By
varying
sulfones,
achieve
site‐specific
labeling
of
non‐native
group
cross‐linking
DNA‐bearing
Furthermore,
our
method
facilitates
selective
pull‐down
enrichment
5‐formylpyrimidine
nucleotides
among
complex
cellular
DNA.
transformation
expands
limited
toolboxes,
providing
novel
avenues
functionalizing
both
native
modifications
on
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 5, 2025
Abstract
Cyclic
peptides
constitute
an
important
drug
modality
since
they
offer
significant
advantages
over
small
molecules
and
macromolecules.
However,
access
to
diverse
chemical
sets
of
cyclic
is
difficult
on
a
large
library
scale.
DNA-encoded
Chemical
Libraries
(DELs)
provide
suitable
tool
obtain
diversity,
but
DELs
made
by
standard
DEL
implementation
cannot
efficiently
explore
their
conformational
diversity.
On
the
other
hand,
dual-display
Encoded
Self-Assembling
(ESAC)
can
be
used
for
modulating
macrocycle
flexibility
two
displayed
connected
in
incremental
fashion.
In
this
work,
we
construct
56
million
ESAC
using
two-step
cyclization
strategy.
We
show
that
varying
level
restraint
essential
discovery
specific
ligands
three
protein
targets
thrombin,
human
alkaline
phosphatase
streptavidin.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
DNA-encoded
libraries
(DELs)
have
emerged
as
powerful
tools
in
drug
discovery.
Protected
amino
acids
serve
essential
building
blocks
the
construction
of
DELs,
resulting
widespread
presence
groups
within
these
libraries.
N-formylation
free
amines
not
only
enhances
activity
lead
compounds
but
also
functions
an
effective
amino-protecting
strategy.
In
this
study,
we
introduce
trimethyl(bromodifluoromethyl)silane
(TMSCF2Br)
a
novel
reagent
for
DEL
synthesis.
This
approach
demonstrates
robustness
DEL-compatible
synthesis
and
enables
library
diversification
through
functional
group
transformation
(FGT).
Additionally,
achieved
efficient
removal
formyl
groups,
enabling
to
be
strategically
used
on-DNA
protection
orthogonal
Fmoc
Boc
groups.
Organic Letters,
Год журнала:
2024,
Номер
26(23), С. 4958 - 4962
Опубликована: Июнь 4, 2024
Inspired
by
previous
selection
outcomes,
we
investigated
and
developed
a
rhodium-promoted
C-H
activation/annulation
reaction
of
DNA-linked
terminal
alkynes
aromatic
acids.
This
exhibits
excellent
efficiency
with
high
conversions
broad
substrate
scope.
Most
importantly,
the
unique
DEL-compatible
conditions
provide
better
scenario
for
yielding
an
isocoumarin
scaffold
compared
to
conventional
organic
conditions,
this
newly
on-DNA
method
has
confirmed
its
feasibility
in
preparing
DNA-encoded
libraries.
A
DNA-compatible
three-component
reaction
is
disclosed
for
the
synthesis
of
on-DNA
polysubstituted
isoxazolidines
that
serve
as
privileged
core
scaffolds
in
numerous
natural
products
and
bioactive
molecules.
This
one-pot
approach
involves
1,3-dipolar
cycloaddition
DNA-tagged
styrenes
with
diazo
compounds
nitrosoarenes
an
aqueous
solution
KOAc.
The
demonstrates
excellent
functional
group
compatibility,
providing
a
conventional
protocol
construction
DNA-labeled
isoxazolidine
library.
Journal of Physics Condensed Matter,
Год журнала:
2024,
Номер
36(42), С. 425401 - 425401
Опубликована: Июнь 7, 2024
The
exploration
of
the
superconducting
properties
antiferromagnetic
parent
compounds
containing
transition
metals
under
pressure
provides
a
unique
idea
for
finding
and
designing
materials
with
better
performance.
In
this
paper,
close
relationship
between
possible
superconductivity
structure
phase
typical
van
der
Waals
layered
material
1
ACS Catalysis,
Год журнала:
2024,
Номер
14(12), С. 9586 - 9593
Опубликована: Июнь 11, 2024
Herein,
the
intermolecular,
photoaerobic
aza-Wacker
coupling
of
azoles
with
alkenes
by
means
dual
and
ternary
selenium-π-acid
multicatalysis
is
presented.
The
title
method
permits
an
expedited
avenue
toward
a
broad
scope
N-allylated
representative
azinones
under
mild
conditions
functional
group
tolerance,
as
showcased
in
more
than
60
examples
including
late-stage
drug
derivatizations.
From
regiochemical
perspective,
protocol
complementary
to
cognate
photoredox
catalytic
olefin
aminations,
they
typically
proceed
through
either
allylic
hydrogen
atom
abstraction
or
single
electron
oxidation
alkene
substrate.
These
methods
predominantly
result
C–N
bond
formations
at
periphery
less
substituted
position
former
π-bond
(i.e.,
anti-Markovnikov
selectivity).
current
process,
however,
operates
radical-polar
crossover
mechanism,
which
solely
affects
selenium
catalyst,
thus
allowing
be
converted
strictly
ionic
two-electron
transfer
regime
Markovnikov
control.
In
addition,
it
shown
that
corresponding
N-vinyl
can
also
accessed
sequential
one-pot
treatment
base,
emphasizing
exquisite
utility
this
method.
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
13(11)
Опубликована: Авг. 26, 2024
Abstract
Primary
amides
play
a
crucial
role
in
organic
and
pharmaceutical
synthesis.
Herein,
we
present
rapid
convenient
method
for
transforming
diverse
DNA‐conjugated
nitriles
into
primary
utilizing
hydrogen
peroxide
potassium
carbonate.
The
substrate
scope
DEL
compatibility
of
this
reaction
were
thoroughly
investigated,
revealing
wide
range
substrates
with
moderate‐to‐excellent
conversion.
This
on‐DNA
transformation
holds
significant
promise
constructing
DNA‐encoded
libraries
(DELs)
enabling
late‐stage
functionalization
to
expand
chemical
diversity.
Our
approach
not
only
highlights
the
versatility
but
also
underscores
its
potential
broad
applications
