Organic Process Research & Development, Год журнала: 2024, Номер unknown
Опубликована: Дек. 7, 2024
As the field of nonprecious metal catalysis continues to expand, we pursue a review series covering selected transformations in this area over short time interval highlight practical advancements. We seek raise awareness both current art and need continue development toward broader applications earth-abundant metals chemical pharmaceutical industries.
Язык: Английский
Journal of Catalysis, Год журнала: 2024, Номер 436, С. 115635 - 115635
Опубликована: Июль 2, 2024
Язык: Английский
Процитировано
0
Organometallics, Год журнала: 2024, Номер 43(20), С. 2574 - 2580
Опубликована: Авг. 10, 2024
The catalytic activity of an NHC-pyridonate-supported nickel(0) complex for Suzuki-Miyaura coupling aryl halides was evaluated. Product formation observed in the absence a basic additive. However, low turnover numbers resulted from competitive catalyst deactivation. nature deactivation-dimerization nickel(II) intermediate-was elucidated through combination NMR monitoring, direct synthesis, and X-ray diffraction. Lewis acidic additives were evaluated with goal improving stability intermediate but failed to enable turnover. Taken together, these findings highlight both promise pitfalls associated incorporating secondary-sphere groups cooperative catalysis.
Язык: Английский
Процитировано
0
ACS Catalysis, Год журнала: 2024, Номер unknown, С. 17535 - 17546
Опубликована: Ноя. 13, 2024
The synthetic innovations in generating β-arylethylamines have the potential to propel advancements drug discovery, as are common structural motifs various bioactive compounds and drugs. Here, we report an efficient Pd (II)-catalyzed method for selective β-C(sp3)-H arylation of aliphatic amines construct β-arylethylamine frameworks. With easy installation removal nitroso directing group on amine nitrogen, this Pd-catalyzed enables (hetero)arylation bonds scaffolds produce tolerates a variety functional groups both coupling partners. It offers approach direct syntheses drugs from native amines, thereby overcoming inherent limitations previously known methods. This identified Pd-catalyst-system features low catalyst loading C–H functionalization high reaction rate, originating pyridone-amide-ester ligand that increases activity while protecting all active species forming inactive complexes. Experimental computational studies disclose valuable effect partially results pendant ester participates several steps C(sp3)-H activation process favors Pd-catalytic cycle.
Язык: Английский
Процитировано
0
Journal of the Iranian Chemical Society, Год журнала: 2024, Номер unknown
Опубликована: Дек. 4, 2024
Язык: Английский
Процитировано
0
Organic Process Research & Development, Год журнала: 2024, Номер unknown
Опубликована: Дек. 7, 2024
As the field of nonprecious metal catalysis continues to expand, we pursue a review series covering selected transformations in this area over short time interval highlight practical advancements. We seek raise awareness both current art and need continue development toward broader applications earth-abundant metals chemical pharmaceutical industries.
Язык: Английский
Процитировано
0