Recent Advances in Nonprecious Metal Catalysis DOI
David J. Bernhardson, Aran K. Hubbell, Robert A. Singer

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

As the field of nonprecious metal catalysis continues to expand, we pursue a review series covering selected transformations in this area over short time interval highlight practical advancements. We seek raise awareness both current art and need continue development toward broader applications earth-abundant metals chemical pharmaceutical industries.

Language: Английский

Suzuki-Miyaura Cross-Coupling using convenient and accessible Nickelocene/Phosphine precatalyst DOI Creative Commons
Łukasz Banach,

Jakub Robaszkiewicz,

Piotr Pawluć

et al.

Journal of Catalysis, Journal Year: 2024, Volume and Issue: 436, P. 115635 - 115635

Published: July 2, 2024

Language: Английский

Citations

0
Deactivation Modes in Nickel-Mediated Suzuki–Miyaura Cross-Coupling Reactions Using an NHC-Pyridonate Ligand DOI Creative Commons
Abhishek A. Kadam, Medina Afandiyeva, William W. Brennessel

et al.

Organometallics, Journal Year: 2024, Volume and Issue: 43(20), P. 2574 - 2580

Published: Aug. 10, 2024

The catalytic activity of an NHC-pyridonate-supported nickel(0) complex for Suzuki-Miyaura coupling aryl halides was evaluated. Product formation observed in the absence a basic additive. However, low turnover numbers resulted from competitive catalyst deactivation. nature deactivation-dimerization nickel(II) intermediate-was elucidated through combination NMR monitoring, direct synthesis, and X-ray diffraction. Lewis acidic additives were evaluated with goal improving stability intermediate but failed to enable turnover. Taken together, these findings highlight both promise pitfalls associated incorporating secondary-sphere groups cooperative catalysis.

Language: Английский

Citations

0
Efficient Construction of β-Arylethylamines via Selective C(sp3)-H Arylation of Aliphatic Amines DOI Creative Commons
Tu Hua,

Xi Deng,

Hongyi Li

et al.

ACS Catalysis, Journal Year: 2024, Volume and Issue: unknown, P. 17535 - 17546

Published: Nov. 13, 2024

The synthetic innovations in generating β-arylethylamines have the potential to propel advancements drug discovery, as are common structural motifs various bioactive compounds and drugs. Here, we report an efficient Pd (II)-catalyzed method for selective β-C(sp3)-H arylation of aliphatic amines construct β-arylethylamine frameworks. With easy installation removal nitroso directing group on amine nitrogen, this Pd-catalyzed enables (hetero)arylation bonds scaffolds produce tolerates a variety functional groups both coupling partners. It offers approach direct syntheses drugs from native amines, thereby overcoming inherent limitations previously known methods. This identified Pd-catalyst-system features low catalyst loading C–H functionalization high reaction rate, originating pyridone-amide-ester ligand that increases activity while protecting all active species forming inactive complexes. Experimental computational studies disclose valuable effect partially results pendant ester participates several steps C(sp3)-H activation process favors Pd-catalytic cycle.

Language: Английский

Citations

0
Decarboxylative Cross-Coupling of Aryl Carboxylic Acids with Arylboronic Acids Using Ag/ZnO Catalyst under Aerobic Conditions in Aqueous Medium DOI
Zahra Bazyar, Zahra Bazyar

Journal of the Iranian Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Language: Английский

Citations

0
Recent Advances in Nonprecious Metal Catalysis DOI
David J. Bernhardson, Aran K. Hubbell, Robert A. Singer

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

As the field of nonprecious metal catalysis continues to expand, we pursue a review series covering selected transformations in this area over short time interval highlight practical advancements. We seek raise awareness both current art and need continue development toward broader applications earth-abundant metals chemical pharmaceutical industries.

Language: Английский

Citations

0