Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 157697 - 157697
Опубликована: Ноя. 1, 2024
Язык: Английский
Chemical Society Reviews, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.
Язык: Английский
Процитировано
12
Seminars in Cancer Biology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Pancreatic ductal adenocarcinoma (PDAC) poses significant therapeutic challenges due to excessive hyaluronic acid (HA) accumulation, which impedes drug delivery. Here, we present a targeted approach reduce HA production by specifically silencing glutamine-fructose-6-phosphate aminotransferase 1 (GFAT1), key enzyme of the hexosamine biosynthesis pathway (HBP) in pancreatic cancer cells. An engineered liposomal system for siGFAT1 delivery, PMLip@siGFAT1, characterized macrophage membrane camouflage, LFC131 peptide-mediated targeting, and calcium phosphate (CaP) as core, was designed ensure prolonged circulation, enhanced inflamed vascular endothelial penetration, subsequent effective tumor cell uptake endosomal escape. Consequently, PMLip@siGFAT1 markedly downregulated level PDAC microenvironment, decompressing vasculature weakening stromal barrier, turn improved permeability chemotherapeutics. In combination with Doxil, demonstrated potent antitumor efficacy minimal systemic toxicity. Importantly, unlike PEGPH20 (hyaluronidase), reduced invasiveness, while preserving skeletal muscle integrity. These findings highlight that holds great potential revitalize downregulation strategies delivery efficacy.
Язык: Английский
Процитировано
1
Biomaterials, Год журнала: 2024, Номер 315, С. 122962 - 122962
Опубликована: Ноя. 12, 2024
Язык: Английский
Процитировано
6
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101799 - 101799
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Май 1, 2025
Despite the success in exploring various aspects of origination and therapeutic strategies, cancer has remained one most dreadful metabolic disorders due to failure eradicate tumors comprehensively frequent recurrence because acquired resistance drugs. Recently, several advancements have been evidenced fabrication smart nanocarriers encapsulated with multiple components. Several reasons for nanoencapsulation include enhancement bioavailability drugs, precise targetability reduce adverse effects on normal cells, ability enable controlled drug release rates at tumor sites. In addition, these protect cargo from deactivation, responsively delivering it based physiological or pathological characteristics tumors. this review, we present approaches therapy, including organic materials, inorganic components, their composites, as well biomembrane-based strategies. These along practical applications potential treatment, are discussed depth, highlighting advantages disadvantages, aiming reveal ultimate prospects enhancing delivery efficiency targeted therapy.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 18, 2024
Abstract The aberrant metabolic activities of tumor cells not only facilitate proliferation but also impair immune cell function and cause an immunosuppressive microenvironment (TME). Thus, reshaping the TME while activating innate immunity is highly desirable challenging. Herein, a multifunctional immunomodulator engineered for near‐infrared light (NIR)‐triggered photodynamic‐metal‐metabolic immunotherapy via “internal trouble outside aggression” strategy. Specifically, endogenous exogenous stimuli‐responsive nanoagent prepared consisting photosensitizer chlorin e6 (Ce6) modified dense silica‐coated rare earth‐doped nanoparticles (ReNPs@SiO 2 (Ce6)), with in situ grown ZIF‐8 on surface loading glucose transporter‐1 (GLUT‐1) inhibitor Fasentin glutaminase‐1 bis‐2‐(5‐phenylacetamido‐1,3,4‐thiadiazol‐2‐yl)ethyl sulfide (BPTES). as‐obtained final product denoted as ReSZ(FB). ReSZ(FB) induces‐ mitochondrial damage releases DNA (mtDNA) NIR‐mediated PDT. Subsequently, Zn 2+ from collaborates mtDNA to activate cGAS‐STING pathway, initiating robust tumor‐specific response. Concurrently, BPTES triggeres energy deprivation by blocking uptake inhibiting glutamine decomposition, thereby reprogramming TME, alleviating immunosuppression. Tumor are damaged trapped into trouble” combining PDT deprivation, sharply enhanced lethality exposes cancer “outside aggression”. Overall, this provides promising paradigm therapy.
Язык: Английский
Процитировано
3
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159880 - 159880
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 2, 2025
Higher and richer nutrient requirements are typical features that distinguish tumor cells from AU: cells, ensuring adequate substrates energy sources for cell proliferation migration. Therefore, deprivation strategies based on targeted technologies can induce impaired viability in which more sensitive than normal cells. In this review, nutrients required by related metabolic pathways introduced, anti-tumor developed to target described. addition the nutritional characteristics of other microenvironment (including macrophages, neutrophils, natural killer T cancer-associated fibroblasts) new also summarized. conclusion, recent advances targeting blockade reviewed, challenges prospects these discussed, theoretical significance optimizing clinical application nutrition strategies.
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 110942 - 110942
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0