Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

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Overcoming Tumor Hypoxic Bismuth-based Ternary Heterojunctions Enable Defect Modulation-augmented Tumor Sonocatalytic Immunotherapy

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122962 - 122962

Published: Nov. 12, 2024

Language: Английский

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Anti‐Tumor Strategies Targeting Nutritional Deprivation: Challenges and Opportunities

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Higher and richer nutrient requirements are typical features that distinguish tumor cells from AU: cells, ensuring adequate substrates energy sources for cell proliferation migration. Therefore, deprivation strategies based on targeted technologies can induce impaired viability in which more sensitive than normal cells. In this review, nutrients required by related metabolic pathways introduced, anti-tumor developed to target described. addition the nutritional characteristics of other microenvironment (including macrophages, neutrophils, natural killer T cancer-associated fibroblasts) new also summarized. conclusion, recent advances targeting blockade reviewed, challenges prospects these discussed, theoretical significance optimizing clinical application nutrition strategies.

Language: Английский

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Role of Ubiquitination-driven Metabolisms in Oncogenesis and Cancer Therapy

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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A photo-accelerated nanoplatform for image-guided synergistic chemo-photodynamic therapy

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110942 - 110942

Published: Feb. 1, 2025

Language: Английский

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siRNA-Encapsulated Biomimetic Liposomes Effectively Inhibit Tumor Cells’ Hexosamine Biosynthesis Pathway for Attenuating Hyaluronan Barriers to Pancreatic Cancer Chemotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Pancreatic ductal adenocarcinoma (PDAC) poses significant therapeutic challenges due to excessive hyaluronic acid (HA) accumulation, which impedes drug delivery. Here, we present a targeted approach reduce HA production by specifically silencing glutamine-fructose-6-phosphate aminotransferase 1 (GFAT1), key enzyme of the hexosamine biosynthesis pathway (HBP) in pancreatic cancer cells. An engineered liposomal system for siGFAT1 delivery, PMLip@siGFAT1, characterized macrophage membrane camouflage, LFC131 peptide-mediated targeting, and calcium phosphate (CaP) as core, was designed ensure prolonged circulation, enhanced inflamed vascular endothelial penetration, subsequent effective tumor cell uptake endosomal escape. Consequently, PMLip@siGFAT1 markedly downregulated level PDAC microenvironment, decompressing vasculature weakening stromal barrier, turn improved permeability chemotherapeutics. In combination with Doxil, demonstrated potent antitumor efficacy minimal systemic toxicity. Importantly, unlike PEGPH20 (hyaluronidase), reduced invasiveness, while preserving skeletal muscle integrity. These findings highlight that holds great potential revitalize downregulation strategies delivery efficacy.

Language: Английский

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GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: Feb. 25, 2025

Abstract Pyroptosis is a regulated form of inflammatory cell death in which Gasdermin D (GSDMD) plays central role as the key effector molecule. GSDMD-mediated pyroptosis characterized by complex biological features and considerable heterogeneity its expression, mechanisms, functional outcomes across various tissues, types, pathological microenvironments. This particularly pronounced inflammation-related diseases tumors. In context diseases, GSDMD expression typically upregulated, activation macrophages, neutrophils, T cells, epithelial mitochondria triggers both pyroptotic non-pyroptotic pathways, leading to release pro-inflammatory cytokines exacerbation tissue damage. However, under certain conditions, may also serve protective immune function. The tumors more manner, where it can either promote evasion or, some instances, induce tumor death. As our understanding GSDMD's continues progress, there have been advancements development inhibitors targeting pyroptosis; however, these therapeutic interventions remain preclinical phase. review systematically examines cellular molecular complexities pyroptosis, with particular emphasis on roles cancer. Furthermore, underscores substantial potential target for precision medicine, highlighting promising clinical applications.

Language: Английский

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Switchable Nanophotosensitizers as Pyroptosis Inducers for Targeted Boosting of Antitumor Photoimmunotherapy

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Photodynamic therapy (PDT) has emerged as a promising modality for cancer treatment, but its clinical application is constrained by unexpected phototoxicity arising from nonspecific photosensitizer activation and their "always-on" nature. Herein, we developed switchable nanophotosensitizer, poly(cation-π) nanoparticles (NP), which achieves supramolecular assembly through cation-π interactions. By coupling choline cationic moieties with aromatic photosensitizers (ZnPc), the polymer facilitates self-assembly driven interactions NP engineering. Surprisingly, photoactivity of ZnPc was completely quenched upon complexation via interactions, thereby significantly avoiding skin phototoxicity. Upon targeting tumor cells, undergoes GSH-responsive degradation process that weakens leading to spontaneous restoration amplifying immunogenic pyroptosis. In vivo studies demonstrated achieved high inhibition rate 84% while effectively This work provides novel perspective enhancing safety efficacy PDT-based treatment.

Language: Английский

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Dual Metabolism-Disrupted Nanoparticles for Reprogramming the Immune Microenvironment to Potentiate Cuproptosis Immunotherapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101799 - 101799

Published: April 1, 2025

Language: Английский

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Nanoarchitecting intelligently encapsulated designs for improved cancer therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

Despite the success in exploring various aspects of origination and therapeutic strategies, cancer has remained one most dreadful metabolic disorders due to failure eradicate tumors comprehensively frequent recurrence because acquired resistance drugs. Recently, several advancements have been evidenced fabrication smart nanocarriers encapsulated with multiple components. Several reasons for nanoencapsulation include enhancement bioavailability drugs, precise targetability reduce adverse effects on normal cells, ability enable controlled drug release rates at tumor sites. In addition, these protect cargo from deactivation, responsively delivering it based physiological or pathological characteristics tumors. this review, we present approaches therapy, including organic materials, inorganic components, their composites, as well biomembrane-based strategies. These along practical applications potential treatment, are discussed depth, highlighting advantages disadvantages, aiming reveal ultimate prospects enhancing delivery efficiency targeted therapy.

Language: Английский

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