Journal of Macromolecular Science Part B,
Год журнала:
2024,
Номер
unknown, С. 1 - 14
Опубликована: Дек. 13, 2024
Dynamic
covalent
macromolecular
networks
represent
a
groundbreaking
advancement
in
adaptive
drug
delivery
systems,
enabling
precise
and
controlled
release
response
to
various
physiological
stimuli.
These
systems
rely
on
dynamic
bonds,
such
as
imine,
disulfide
boronic
ester
linkages,
which
are
capable
of
reversible
bond
exchange.
The
ability
these
bonds
respond
environmental
triggers
like
pH,
temperature,
light
redox
conditions,
makes
them
highly
adaptable
for
tailored
release.
This
review
explores
the
fundamentals
chemistry
design
synthesis
networks,
highlighting
their
integrate
diverse
stimuli-responsiveness.
Key
applications
targeted
cancer
therapy,
smart
hydrogels
wound
healing,
co-delivery
therapeutics
long-term
discussed.
also
finding
place
tissue
engineering,
where
can
be
synchronized
with
regeneration.
Despite
numerous
advantages
challenges
remain
regarding
scalability,
biocompatibility
stability.
Overall,
hold
great
potential
revolutionize
field
by
offering
enhanced
control,
specificity
therapeutic
efficacy
complex
medical
treatments,
chronic
disease
management.
Journal of Controlled Release,
Год журнала:
2025,
Номер
379, С. 30 - 44
Опубликована: Янв. 8, 2025
New
multipurpose
prevention
technology
products
for
use
by
women,
focused
on
reducing
HIV
infection
and
preventing
unwanted
pregnancies,
are
a
global
health
priority.
Discreet
long-acting
formulations
will
empower
women
with
greater
choice
around
their
sexual
health.
This
paper
outlines
the
development
of
that
enables
multiple
drugs
to
be
incorporated
within
one
injectable
platform.
fixed-dose
combination
product
is
formed
from
phosphorylated
D-peptide
(naphthalene-2-ly)-acetyl-diphenylalanine-lysine-tyrosine-glycine-OH
(Napffky(p)G-OH)
highly
hydrophobic
MIV-150
(HIV
antiretroviral)
etonogestrel
(contraceptive)
solubilized
together
aqueous
solvents.
Upon
subcutaneous
injection,
this
D-peptide-drug
self-assembles
in
response
phosphatase
enzymes
present
skin
space
form
an
situ
forming
drug-releasing
hydrogel
depot.
Oscillatory
rheology
confirmed
formation
hydrogels,
which
began
~10
s
exposure
3.98
U/mL
continued
~198
mins
Napffk(MIV-150)y(p)G-OH
+
Napffk(ENG)y(p)G-OH
(8:2
ratio).
Biostability
against
proteases,
important
consideration
injectables,
was
demonstrated
at
least
28
days
vitro.
Covalent
attachment
each
drug
via
ester
linkage
enabled
sustained
release
unmodified
hydrolysis
linker.
significantly
reduced
initial
burst.
Low
toxicity
also
vitro
cell
culture
(MTS,
LHS,
Live/Dead®)
vivo
studies
(H&E
staining).
The
fixed
dose
able
deliver
clinically
relevant
concentrations
Sprague-Dawley
rats
49
days,
providing
proof-of-concept
hydrogel-forming
D-peptides
as
platform
delivery
drugs.
Polymers,
Год журнала:
2025,
Номер
17(7), С. 930 - 930
Опубликована: Март 29, 2025
The
fluorenyl
methyl
oxycarbonyl
phenylalanyl-phenylalanine
ester
(Fmoc-Phe-Phe-Ome)
was
synthetized
using
the
liquid
phase
synthesis
strategy.
This
derivative
separated
by
hydrophobic
interaction
chromatography,
its
purity
analyzed
RP-HPLC
and
it
characterized
mass
spectrometry.
extremely
peptide
conjugate
incorporated
into
aqueous
solutions
of
Pluronic®
F127
at
low
temperatures
(below
10
°C).
temperature
induced
sol-gel
transition
investigated
rheological
measurements.
A
delay
transition,
caused
presence
concentrations
Fmoc-Phe-Phe-Ome
(up
to
1%),
enables
better
control
gelation
process.
viscoelastic
properties
hybrid
networks
were
37
°C
in
different
shear
conditions.
Pluronic/peptide
systems
reported
herein
provide
promising
alternatives
for
developing
innovative
injectable
gels
as
suitable
platforms
cancer
treatment.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Ноя. 6, 2024
To
address
the
issue
of
nonspecific
biodistribution
a
chemotherapeutic
drug,
stable
[2]pseudorotaxane
complexes
(PK@CAOPP
and
PR@CAOPP)
are
used
to
demonstrate
proof
concept.
Cationic
-PPh3
+
moiety
in
CAOPP
allows
specific
localization
PK@CAOPP/
PR@CAOPP
mitochondrial
membrane
(MM).
Electrostatic
interaction
between
cationic
LysinePK
or
ArgininePR
negatively
charged
phosphoesterCAOPP
functionality
favours
strong
adduct
formation.
The
ALP-induced
hydrolytic
cleavage
phosphoester
cancer
cells
triggers
dephosphorylation
releases
PK/
PR
from
PK@CAOPP/PR@CAOPP.
PK
PR,
derived
Phe-Phe
dipeptide,
formed
fibril-like
molecular
aggregates
MM
induce
dysfunction,
depolarization,
ROS
generation
apoptotic
MCF7
cell
death.
Such
phenomena
were
not
observed
ALP-negative
HEK293
normal
cells.
These
propositions
confirmed
through
control
studies
using
NBDK
PE,
other
guest
molecules.
Smaller
size
inclusion
short
peptides
(PK
PR)
within
hydrophobic
interior
CAOPP,
attributed
their
stability
blood
serum.
Thus,
we
have
demonstrated
use
supramolecular
adducts
as
potential
therapeutic
option
for
treating
without
affecting
healthy
efficacy
was
also
established
with
an
in-vivo
tumour
xenograft
model
Balb/c
nude
mice.
Biomaterials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
The
development
of
new
multi-responsive
injectable
hydrogels
with
cascades
or
even
synergistic
effects
will
be
great
significance
in
the
field
precision
medicine.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Concurrent
localized
radiotherapy
and
systemic
chemotherapy
are
standards
of
care
for
many
cancers,
but
these
treatment
regimens
cause
severe
adverse
effects
in
patients.
Herein,
we
report
the
design
a
mixed-ligand
nanoscale
metal–organic
framework
(nMOF)
with
ability
to
simultaneously
enhance
radiotherapeutic
trigger
release
potent
chemotherapeutic
under
X-ray
irradiation.
We
synthesized
new
functional
quaterphenyl
dicarboxylate
ligand
conjugated
SN38
(H2QP-SN)
via
hydroxyl
radical-responsive
covalent
linkage.
Because
similar
length
QP-SN
bis(p-benzoato)porphyrin
(DBP)
ligands,
was
incorporated
into
Hf-DBP
nMOF
afford
novel
multifunctional
Hf-DBP-QP-SN
good
biocompatibility.
not
only
enhances
radiation
damage
tumors
unique
radiotherapy-radiodynamic
therapy
(RT-RDT)
process
also
increases
·OH
generation
from
radiolysis
electron-dense
Hf12
secondary
building
units
(SBUs)
chemotherapy.
Elevated
levels
hydrogen
peroxide
tumor
microenvironment
further
stimulate
by
enhancing
With
low
doses
irradiation,
suppressed
growth
CT26
colon
4T1
breast
93.5%
95.2%,
respectively,
without
any
sign
general
toxicity.
Our
study
highlights
potential
using
ionizing
radiation-mediated
chemistry
on-demand
activation
nanotherapeutics
synergistic
causing
effects.
Abstract
Aromatic
residues
in
assembling
peptides
play
a
crucial
role
driving
peptide
self‐assembly
through
π–π
stacking
and
hydrophobic
interactions.
Although
various
aromatic
capping
groups
have
been
extensively
studied,
systematic
investigations
into
the
effects
of
single
amino
acids
remain
limited.
In
this
study,
influence
aromatic‐aromatic
interactions
on
disulfide‐rich
is
systematically
investigated
by
incorporating
three
different
acids.
Their
folding
propensity,
self‐assembling
properties,
rheological
behaviors
are
evaluated.
These
results
indicate
that
significant
effect
abilities,
as
determined
critical
aggregation
concentration
(CAC)
measurements.
Furthermore,
biocompatibility
these
hydrogels
assessed,
their
potential
for
3D
cell
culture
explored.
The
injectable
F1‐ox
hydrogel
demonstrate
excellent
SHED
NIH3T3
cells
exhibit
porous
structure
facilitates
nutrient
cellular
metabolic
waste
exchange.
This
work
provides
new
insights
molecular
design
peptide‐based
biomaterials,
with
focus
impact
peptides.
Abstract
Peptoids
are
bio‐inspired
peptidomimetic
polymers
that
can
be
designed
to
self‐assemble
into
a
variety
of
nanostructures.
Among
these
different
assemblies,
peptoid
nanosheets
the
most
studied.
Peptoid
2D
highly
ordered
nanostructures,
able
free
float
in
aqueous
solutions
while
featuring
versatile
chemical
displays
tuned
incorporate
plethora
functional
units.
In
this
review,
synthetic
approach
used
prepare
sequence‐defined
oligomers
and
highlight
their
main
characteristics
is
introduced.
The
ability
peptoids
fold
nanostructures
then
reviewed
with
an
extensive
emphasis
on
nanosheets,
physico–chemical
characteristics,
assembly
mechanism,
stability.
A
particular
focus
also
placed
functionalization
incorporated
tune
properties
toward
specific
applications,
especially
within
fields
biology
medicine.
Finally,
comparison
between
other
nanomaterials
discussed
address
challenges
current
underline
future
development
field
biology.
