Palladium-catalysed asymmetric cascade transformations of 4-alken-2-ynyl carbonates to construct complex frameworks DOI Creative Commons

Ze-Liang He,

Li Li, Zhichao Chen

и другие.

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

A palladium-catalysed asymmetric auto-tandem reaction between 4-alken-2-ynyl carbonates and diverse ortho-functionalized activated alkenes is reported, giving complex frameworks in moderate yields with excellent chemo-, regio- stereoselectivity.

Язык: Английский

Recent Advances in Electrochemical Carboxylation with CO2 DOI

Guo‐Quan Sun,

Li‐Li Liao,

Chuan‐Kun Ran

и другие.

Accounts of Chemical Research, Год журнала: 2024, Номер 57(18), С. 2728 - 2745

Опубликована: Сен. 3, 2024

ConspectusCarbon dioxide (CO

Процитировано

36

Electro-reductive carboxylation of C Cl bonds in unactivated alkyl chlorides and polyvinyl chloride with CO2 DOI
Li Li, Zhi-xin Yan,

Chuan‐Kun Ran

и другие.

Chinese Chemical Letters, Год журнала: 2024, Номер 35(12), С. 110104 - 110104

Опубликована: Июнь 8, 2024

Язык: Английский

Процитировано

9

Electroreductive Cross-Coupling Reactions: Carboxylation, Deuteration, and Alkylation DOI
Pengfei Li, Yanwei Wang, Hanying Zhao

и другие.

Accounts of Chemical Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

ConspectusElectrochemistry has been used as a tool to drive chemical reactions for more than two centuries. With the help of an electrode and power source, chemists are provided with system whose potential can be precisely dialed in. The theoretically infinite redox range renders electrochemistry capable oxidizing or reducing some most tenacious compounds. Indeed, electroreduction offers alternative generating highly active intermediates from electrophiles (e.g., halides, alkenes, etc.) in organic synthesis, which untouchable traditional reduction methods. Meanwhile, reductive coupling extensively utilized both industrial academic settings due their ability swiftly, accurately, effectively construct C–C C–X bonds, present innovative approaches synthesizing complex molecules. Nonetheless, its application is constrained by several inherent limitations: (a) requirement stoichiometric quantities agents, (b) scarce activation strategies inert substrates high potentials, (c) incomplete mechanistic elucidation, (d) challenges isolation intermediates. merging represents attractive approach address above limitations synthesis seen increasing use synthetic community over past few years.Since 2020, our group dedicated developing electroreductive cross-coupling using readily available small molecules, such arenes, CO2, D2O, value-added products. Electroreductive chemistry versatile powerful capacity precise selectivity control, allowed us develop three electrochemical modes lab: (1) An economically advantageous direct (EDR) strategy that emphasizes efficiency, achieves atom utilization, minimizes unnecessary atomic waste. (2) A class organo-mediated (EOMR) methods controlling reaction pathways. This allows modulation processes enhance efficiency selectivity. (3) metal-catalyzed (EMCR) method enables selective functionalization specific bonds functional groups under mild conditions, thereby occurrence side reactions. We commenced studies establishing organic-mediator-promoted carboxylation aryl alkyl halides. was then employed arylcarboxylation simple styrenes halides manner. electrolysis arenes epoxides CO2 carboxyl source achieved. Moreover, through adjustment we successfully accomplished deuteration olefins, unactivated enabling efficient formation D-labeled Finally, building on previous understanding developed series alkylation enable C(sp3)–C(sp3)

Язык: Английский

Процитировано

8

Asymmetric Multicomponent Propargylations via Carbon Dioxide Shuttling and Fixation DOI

Zi‐Han Li,

Jiang-Shan Ma,

Han-Yu Lu

и другие.

ACS Catalysis, Год журнала: 2024, Номер 14(15), С. 11646 - 11656

Опубликована: Июль 22, 2024

Язык: Английский

Процитировано

7

A review of recent advances in electrochemical and photoelectrochemical late-stage functionalization classified by anodic oxidation, cathodic reduction, and paired electrolysis DOI Creative Commons
Nian Li, Ruzal Sitdikov, Ajit Prabhakar Kale

и другие.

Beilstein Journal of Organic Chemistry, Год журнала: 2024, Номер 20, С. 2500 - 2566

Опубликована: Окт. 9, 2024

With the resurgence of electrosynthesis in organic chemistry, there is a significant increase number routes available for late-stage functionalization (LSF) drugs. Electrosynthetic methods, which obviate need hazardous chemical oxidants or reductants, offer unprecedented control reactions through continuous variation applied potential and possibility combination with photochemical processes. This capability substantial advantage performing electrochemical photoelectrochemical LSF. Ultimately, these protocols are poised to become vital component medicinal chemist's toolkit. In this review, we discuss that have been demonstrated be applicable LSF pharmaceutical drugs, their derivatives, natural substrates. We present analyze representative examples illustrate electrochemistry photoelectrochemistry valuable molecular scaffolds.

Язык: Английский

Процитировано

7

Organo-mediator enabled electrochemical transformations DOI
Wei-Mei Zeng, Yanwei Wang,

Chunhui Peng

и другие.

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review highlights organo-mediators that enable electrochemical reactions via outer-sphere electron transfer (ET), offering advantages such as availability, tunability, and simplified post-processing compared to direct electrolysis.

Язык: Английский

Процитировано

1

Advances in photochemical/electrochemical synthesis of heterocyclic compounds from carbon dioxide DOI
Yuyang Xie, Ying‐Ming Pan

Green Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This paper reviews progress in the photochemical/electrochemical construction of heterocyclic compounds using CO 2 , differentiating between various reaction types and elucidating their underlying mechanisms as well potential applications.

Язык: Английский

Процитировано

5

Nickel‐Catalyzed Atroposelective Carbo‐Carboxylation of Alkynes with CO2: En Route to Axially Chiral Carboxylic Acids DOI
Chao Li, Xiao‐Wang Chen, Li‐Li Liao

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 64(1)

Опубликована: Ноя. 7, 2024

Abstract Precise synthesis of carboxylic acids via catalytic carboxylation with CO 2 is highly appealing. Although considerable advancements have been achieved in difunctionalizing unsaturated hydrocarbons, the asymmetric variants are conspicuously underdeveloped, particularly addressing axially chiral alkenes. Herein, we report first atroposelective alkynes . A variety valuable obtained good yields and high chemo‐, regio‐, Z/E enantio‐selectivities. Notably, an unexpected anti ‐selective carbo‐carboxylation observed sp ‐hybrid carbo‐electrophile‐initiated reductive alkynes. Mechanistic studies including DFT calculation elucidate origin induction ‐selectivity vinyl‐carboxylation

Язык: Английский

Процитировано

3

Recent Advances in Electrochemical Carboxylation of Inert Chemical Bonds with Carbon Dioxide DOI
Xiaotong Gao,

Yuqing Zhong,

Nan Feng

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(10), С. 3043 - 3043

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

3

Design of a chiral molecular pocket in a Ni(II) complex to improve stereoselectivity in the kinetic resolution of racemic epoxides with CO2 DOI Creative Commons
Mikhail A. Emelyanov,

Alexander V. Bachinskiy,

Yana V. Derkach

и другие.

Tetrahedron Chem, Год журнала: 2024, Номер 12, С. 100115 - 100115

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

3