Chemical Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 27, 2024
A palladium-catalysed asymmetric auto-tandem reaction between 4-alken-2-ynyl carbonates and diverse ortho-functionalized activated alkenes is reported, giving complex frameworks in moderate yields with excellent chemo-, regio- stereoselectivity.
Язык: Английский
Accounts of Chemical Research, Год журнала: 2024, Номер 57(18), С. 2728 - 2745
Опубликована: Сен. 3, 2024
ConspectusCarbon dioxide (CO
Процитировано
36
Chinese Chemical Letters, Год журнала: 2024, Номер 35(12), С. 110104 - 110104
Опубликована: Июнь 8, 2024
Язык: Английский
Процитировано
9
Accounts of Chemical Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 13, 2024
ConspectusElectrochemistry has been used as a tool to drive chemical reactions for more than two centuries. With the help of an electrode and power source, chemists are provided with system whose potential can be precisely dialed in. The theoretically infinite redox range renders electrochemistry capable oxidizing or reducing some most tenacious compounds. Indeed, electroreduction offers alternative generating highly active intermediates from electrophiles (e.g., halides, alkenes, etc.) in organic synthesis, which untouchable traditional reduction methods. Meanwhile, reductive coupling extensively utilized both industrial academic settings due their ability swiftly, accurately, effectively construct C–C C–X bonds, present innovative approaches synthesizing complex molecules. Nonetheless, its application is constrained by several inherent limitations: (a) requirement stoichiometric quantities agents, (b) scarce activation strategies inert substrates high potentials, (c) incomplete mechanistic elucidation, (d) challenges isolation intermediates. merging represents attractive approach address above limitations synthesis seen increasing use synthetic community over past few years.Since 2020, our group dedicated developing electroreductive cross-coupling using readily available small molecules, such arenes, CO2, D2O, value-added products. Electroreductive chemistry versatile powerful capacity precise selectivity control, allowed us develop three electrochemical modes lab: (1) An economically advantageous direct (EDR) strategy that emphasizes efficiency, achieves atom utilization, minimizes unnecessary atomic waste. (2) A class organo-mediated (EOMR) methods controlling reaction pathways. This allows modulation processes enhance efficiency selectivity. (3) metal-catalyzed (EMCR) method enables selective functionalization specific bonds functional groups under mild conditions, thereby occurrence side reactions. We commenced studies establishing organic-mediator-promoted carboxylation aryl alkyl halides. was then employed arylcarboxylation simple styrenes halides manner. electrolysis arenes epoxides CO2 carboxyl source achieved. Moreover, through adjustment we successfully accomplished deuteration olefins, unactivated enabling efficient formation D-labeled Finally, building on previous understanding developed series alkylation enable C(sp3)–C(sp3)
Язык: Английский
Процитировано
8
ACS Catalysis, Год журнала: 2024, Номер 14(15), С. 11646 - 11656
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
7
Beilstein Journal of Organic Chemistry, Год журнала: 2024, Номер 20, С. 2500 - 2566
Опубликована: Окт. 9, 2024
With the resurgence of electrosynthesis in organic chemistry, there is a significant increase number routes available for late-stage functionalization (LSF) drugs. Electrosynthetic methods, which obviate need hazardous chemical oxidants or reductants, offer unprecedented control reactions through continuous variation applied potential and possibility combination with photochemical processes. This capability substantial advantage performing electrochemical photoelectrochemical LSF. Ultimately, these protocols are poised to become vital component medicinal chemist's toolkit. In this review, we discuss that have been demonstrated be applicable LSF pharmaceutical drugs, their derivatives, natural substrates. We present analyze representative examples illustrate electrochemistry photoelectrochemistry valuable molecular scaffolds.
Язык: Английский
Процитировано
7
Chemical Society Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review highlights organo-mediators that enable electrochemical reactions via outer-sphere electron transfer (ET), offering advantages such as availability, tunability, and simplified post-processing compared to direct electrolysis.
Язык: Английский
Процитировано
1
Green Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This paper reviews progress in the photochemical/electrochemical construction of heterocyclic compounds using CO 2 , differentiating between various reaction types and elucidating their underlying mechanisms as well potential applications.
Язык: Английский
Процитировано
5
Angewandte Chemie International Edition, Год журнала: 2024, Номер 64(1)
Опубликована: Ноя. 7, 2024
Abstract Precise synthesis of carboxylic acids via catalytic carboxylation with CO 2 is highly appealing. Although considerable advancements have been achieved in difunctionalizing unsaturated hydrocarbons, the asymmetric variants are conspicuously underdeveloped, particularly addressing axially chiral alkenes. Herein, we report first atroposelective alkynes . A variety valuable obtained good yields and high chemo‐, regio‐, Z/E enantio‐selectivities. Notably, an unexpected anti ‐selective carbo‐carboxylation observed sp ‐hybrid carbo‐electrophile‐initiated reductive alkynes. Mechanistic studies including DFT calculation elucidate origin induction ‐selectivity vinyl‐carboxylation
Язык: Английский
Процитировано
3
Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(10), С. 3043 - 3043
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
3
Tetrahedron Chem, Год журнала: 2024, Номер 12, С. 100115 - 100115
Опубликована: Ноя. 28, 2024
Язык: Английский
Процитировано
3