Defect‐Engineered Biomimetic Piezoelectric Nanocomposites With Enhanced ROS Production, Macrophage Re‐polarization, and Ca²⁺ Channel Activation for Therapy of MRSA‐Infected Wounds and Osteomyelitis

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Antibiotic-resistant bacteria often cause lethal infections in both the surficial and deep organs of humans. Failure antibiotics resistant leads to more effective alternative therapies, like spatiotemporally controllable piezodynamic therapy (PZDT) with penetration. Currently, PZDT demands further investigation for improved treatment outcomes corresponding therapeutic mechanisms. Herein, a nanocomposite cloaked is reported biomimetic coating TLR-upregulated macrophage membrane targeted against MRSA-induced skin wound infection osteomyelitis, representing models, respectively. To boost efficacy, crystal defect engineering applied by impregnating Fe2+ into bismuth oxy-iodide nanosheets increase defects. This results significantly higher piezoelectric coefficient than previous reports, contributing an amplified reactive oxygen species generation bacterial killing. More importantly, notable effect not only re-programs macrophages anti-inflammatory M2 phenotype accelerating healing but also stimulates opening piezo-stimulated Ca2+ channels boosts differentiation mesenchymal stem cells osteoblasts expediting bone tissue repair osteomyelitis model. Moreover, Fe-doping supplements T2-magnetic resonance imaging real-time visualization distribution. theranostic system opens new avenue future drug-resistant bacteria-caused diseases.

Язык: Английский

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Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future

Язык: Английский

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Piezoelectric Biomaterial with Advanced Design for Tissue Infection Repair

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Abstract Bacterial infection has become the most dangerous factor in tissue repair, which strongly affects regeneration efficiency and wellness of patients. Piezoelectric materials exhibit outstanding advantage producing electrons without external power supply. The ability electron enrichment reactive oxygen species generation through noninvasive stimulations enables piezoelectric potential applications antibacterial. Many studies have proved feasibility as a functional addition antibacterial biomaterial. In fact, numerous with ingenious designs are reported to be effective processes. This review summarizes mechanisms piezoelectric, illuminating their combating bacteria. Recent advancement design construction biomaterial including defect engineering, heterojunction, synergy metal composite scaffold configuration thoroughly reviewed. Moreover, therapeutic effects common tissues requirements introduced, such orthopedics, dental, wound healing. Finally, development prospects points deserving further exploration listed. is expected provide valuable insight into relationship between processes materials, inspiring constructive this emerging scientific discipline.

Язык: Английский

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Oxygen Vacancy Engineering of Bi₄Ti₃O₁₂ Piezocatalyst Driving In Situ H₂O₂ Evolution for Self-Cycled Fenton-Like Degradation of Pollutants

Inorganic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

In this work, we synthesized a Bi4Ti3O12 piezocatalyst with surface oxygen vacancy (BTO-Ov) to facilitate in situ hydrogen peroxide (H2O2) production and establish piezocatalytic self-cycled Fenton-like system for degradation of pollutants. Notably, the H2O2 evolution rate from BTO-Ov catalyst reaches 558.8 μmol g–1 h–1 when utilizing pure water, significantly exceeding obtained BTO (274.6 h–1). Furthermore, can be enhanced 1091.6 addition ethanol as sacrificial agent endows robust stability. (BTO-Ov/Fe0), efficiency methyl orange (MO) dye pollutant achieve 91.9% within 20 min, coupled high kinetic coefficient 0.117 min–1, indicating excellent catalytic activity. Relevant characterization results reveal that introduction improves piezoelectricity, reduces band gap BTO, enhances charge carrier transfer separation, facilitates dual-channel reaction mechanism, thereby achieving superior performance. This work not only synthesis valuable chemicals but also offers cost-effective sustainable approach wastewater purification.

Язык: Английский

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The Function of Photocatalytic Performance and Carrier Separation Efficiency Tuned by Doping Content in Homogeneous Photocatalysts

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Homogeneous matrix materials are considered to be a solid guarantee of site-point charge transfer reactions because they the main body light absorption, photogenerated carrier separation, migration, and recombination processes. Elucidating effect separation efficiency on catalytic performance is great significance for overcoming optimization obstacles homogeneous parts providing new design strategies. In this study, TiO2 doped with Fe as research object quantifies dynamics while trying avoid large site lattice changes. The direct correlation between photocatalytic different doping content samples clearly elucidated by dynamic characterization results. Doping 0.213 wt.% exhibits best performance, achieving CO yield 35.12 µmol g-1 h-1. Especially, femtosecond transient absorption spectroscopy demonstrates defect level formed enhances electrons. clear relationship shown above, which capacity mapping efficiency, rather than linear dependence sites oxygen vacancies, fully potential simple strategies photocatalysts.

Язык: Английский

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Safe-by-design strategies towards bismuth-based nanomaterials in tumor diagnosis and therapy

Nano Today, Год журнала: 2025, Номер 62, С. 102714 - 102714

Опубликована: Март 15, 2025

Язык: Английский

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3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 24, 2025

Electrical stimulation has been shown to regulate early immunity and late-stage osteogenesis in bone repair. However, achieving in-situ electrical the form of self-power vivo during initial postoperative stages when patients have limited mobility remains challenging. In this study, we developed a 3D-printed self-powered composite scaffold composed shape memory polyurethane elastomers (SMPU) polyvinylidene fluoride (PVDF) piezoelectric nanofibers. The demonstrates excellent performance, allowing for minimally invasive implantation. During process, can provide mechanical force PVDF nanofibers generate charge. Therefore, was achieved through integration process effects, it be used period. Additionally, output voltage under continuous stimulation, indicating that apply sustained rehabilitation exercises regain mobility. Both cell experiments animal studies confirmed effectively immune microenvironment enhance osteogenesis. This study successfully achieves by integrating which is expected an effective repair strategy tissue engineering.

Язык: Английский

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Carbon nanotube directed synthesis of blue TiO2 with oxygen vacancy for sonocatalytic H2 production

Renewable Energy, Год журнала: 2025, Номер unknown, С. 122379 - 122379

Опубликована: Янв. 1, 2025

Язык: Английский

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Surface Bi-vacancy and corona polarization engineered nanosheets with sonopiezocatalytic antibacterial activity for wound healing

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

BiOBr-BiVP nanosheets enhance piezoelectric properties by improving charge separation and migration. Meanwhile, Bi vacancies increase adsorption reaction sites for ROS CO generation, achieving the bacterial eradication wound healing.

Язык: Английский

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Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS 2 ) nanoflowers are strategically designed, which exhibit enhanced effects. Specifically, introduction Co single atom not only induces lattice distortion out‐of‐plane polarization but also leads to formation numerous vacancies. These changes collectively narrow intrinsic bandgap material, facilitating effective separation migration charge carriers, enabling efficient production reactive oxygen species under ultrasound stimulation. Additionally, SA‐Co@MoS demonstrate improved enzymatic activity glutathione depletion capabilities attributed mixed valence states Co, intensifying oxidative stress cells, leading cell cycle arrest apoptosis, while inactivation peroxidase 4 ferroptosis. Both vitro vivo results indicate that can significantly eliminate cells. This study offers valuable insights into exploration doping‐enhanced sonosensitizers for cancer treatment, potentially paving way advancements field synergistic enzyodynamic therapy.

Язык: Английский

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