Recent Advances in Catalytic Asymmetric Ketone Allylations and Their Applications

ACS Catalysis, Год журнала: 2025, Номер 15(3), С. 1487 - 1513

Опубликована: Янв. 9, 2025

Due to the wide applications of resulting chiral tertiary homoallylic alcohols in organic synthesis, catalytic asymmetric ketone allylations have attracted continuous attention from synthetic chemists. Despite inherent difficulty enantiofacial differentiation and low reactivity ketones, past two decades witnessed rapid progress allylation ketones. Many efficient methods been reported, with discovery unprecedented catalysts reagents. The current Review aims give a summary achievements this area 2011 date is divided into six parts according reagents that were applied. Special paid scope application each method brief introduction corresponding mechanisms.

Язык: Английский

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Stereoconvergent and Enantioselective Synthesis of Z-Homoallylic Alcohols via Nickel-Catalyzed Reductive Coupling of Z/E-1,3-Dienes with Aldehydes

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(32), С. 22157 - 22165

Опубликована: Авг. 5, 2024

Stereoconvergent reactions enable the transformation of mixed stereoisomers into well-defined, chiral products─a crucial strategy for handling

Язык: Английский

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Enantioselective Synthesis of vic-Aminoalcohol Derivatives by Nickel-Catalyzed Reductive Coupling of Aldehydes with Protected Amino-pentadienoates

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

A VAPOL-derived phosphoramidite ligand is uniquely effective at reverting the regiochemical course of nickel-catalyzed reactions aldehydes with carbamate-protected 5-amino-2,4-pentadienoates as "push/pull" dienes; ensuing carbonyl α-amino-homoallylation reaction affords

Язык: Английский

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Research Progress on Copper(I)-Catalyzed Asymmetric Allylation of Ketones or Ketimines

Acta Chimica Sinica, Год журнала: 2024, Номер 82(12), С. 1274 - 1274

Опубликована: Янв. 1, 2024

Язык: Английский

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