Enantioselective Nickel-Catalyzed Electrochemical Reductive Conjugate Alkenylation of α,β-Unsaturated Ketones DOI Creative Commons
Siriphong Somprasong, Baonian Wan, Syuzanna R. Harutyunyan

и другие.

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

We present an asymmetric electrochemical nickel-catalysed reductive conjugate addition of alkenyl bromides/aryl iodides to α,β-unsaturated ketones in undivided cell, which afforded β-alkenylate/arylate high yields with excellent enantioselectivities.

Язык: Английский

Electrochemically Driven Nickel‐Catalyzed Enantioselective Hydro‐Arylation/Alkenylation of Enones DOI Creative Commons
Zenghui Ye, Weiyuan Ma, Xi Zhang

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Abstract Herein, the study reports first electrochemical nickel‐catalyzed enantioselective hydro‐arylation/alkenylation of enones in an undivided cell with low‐cost electrodes absence external reductants and supporting electrolytes. Aryl bromides/iodides/triflates or alkenyl bromides are employed as electrophiles for efficient preparation more than 56 valuable β‐arylated/alkenylated ketones a simple manner (up to 97% yield, ee). With advantages electrochemistry, excellent functional group tolerance late‐stage modification complex natural products pharmaceuticals made established protocol greener economic. Mechanism investigation suggests that Ni I /Ni III cycle may be involved this electro‐reductive reaction rather metal reductant driven 0 II cycle. Overall, activation turnover nickel catalyst avoid drawbacks posed by employment stoichiometric amount sensitive powder reductants.

Язык: Английский

Процитировано

2
Cobalt-Catalyzed Enantioselective Reductive Addition of Ketimine with Cyclopropyl Chloride to Construct the Chiral Amino Esters Bearing Cyclopropyl Fragments DOI
Jiangtao Hu, Tingting Xia, Xianqing Wu

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(22), С. 6311 - 6318

Опубликована: Янв. 1, 2024

Co-catalyzed asymmetric reductive addition of ketimine with cyclopropyl chloride has been realized to access diverse chiral amino esters bearing fragments broad functional group tolerance and excellent enantioselectivities.

Язык: Английский

Процитировано

1
Enantioselective Nickel-Catalyzed Electrochemical Reductive Conjugate Alkenylation of α,β-Unsaturated Ketones DOI Creative Commons
Siriphong Somprasong, Baonian Wan, Syuzanna R. Harutyunyan

и другие.

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

We present an asymmetric electrochemical nickel-catalysed reductive conjugate addition of alkenyl bromides/aryl iodides to α,β-unsaturated ketones in undivided cell, which afforded β-alkenylate/arylate high yields with excellent enantioselectivities.

Язык: Английский

Процитировано

0