Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
533, С. 216549 - 216549
Опубликована: Фев. 27, 2025
Язык: Английский
Semiconducting Open‐Shell Radicals for Precise Tumor Activatable Phototheranostics
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Semiconducting
open-shell
radicals
(SORs)
have
promising
potential
for
the
development
of
phototheranostic
agents,
enabling
tumor
bioimaging
and
boosting
tumorous
reactive
oxygen
species
(ROS).
Herein,
a
new
class
semiconducting
perylene
diimide
(PDI),
designated
as
PDI(Br)n
with
various
numbers
bromine
(Br)
atoms
modified
on
PDI's
bay/ortho
positions
is
reported.
demonstrated
to
transform
into
radical
anion,
[PDI(Br)n]•-,
in
reducing
solution,
typical
g-value
2.0022.
Specifically,
[PDI(Br)4/6]•-
generated
weakly
reductive
tumor-mimicking
solution
exhibits
high
stability
air.
Quantum
chemical
kinetic
simulation
ultrafast
femtosecond
transient
absorption
spectroscopy
indicate
that
[PDI(Br)6]•-
has
low
π-π
stacking
energy
(0.35
eV),
fast
electron
transfer
rate
(192.4
ps)
gap
PDI(Br)6
(ΔES1,
T1
=
1.307
eV,
ΔES1,
T2
0.324
eV)
respectively,
which
together
result
excited-state
charge
characters.
The
nanoparticle
radicals,
[PDI(Br)6]
NPs•-,
specifically
enable
chemodynamic
type-I
photodynamic
ROS
generation
tumors,
including
superoxide
hydroxyl
elicit
immunogenic
cell
death
effect.
Also,
NPs•-
facilitate
activatable
bioimaging-guided
therapy
due
their
photoacoustic
signal
at
808
nm
NIR-II
emission
1115
nm.
work
paves
way
design
SORs
precise
cancer
theranostics.
Язык: Английский
Organic Radiosensitizer with Aggregation-Induced Emission Characteristics for Tumor Ablation through Synergistic Apoptosis and Immunogenic Cell Death
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Inspired
by
the
clinical
application
of
thermotherapy
to
promote
efficacy
radiotherapy,
this
study
demonstrates
multimodal
diagnostic
pure
organic
nanoparticles
in
combined
treatment
tumors
through
imaging
and
photothermal
properties.
The
developed
demonstrated
unique
properties
multiple
functionalities,
including
excellent
photostability
thermostability,
strong
fluorescence
emission
near-infrared-II
(NIR-II)
region,
extremely
high
conversion
efficiency,
good
biocompatibility,
significant
radiosensitizing
properties,
effective
tumor
site
accumulation.
In
vitro
vivo
evaluations
that
these
are
ideal
candidates
for
synergistic
radiotherapy
guided
NIR-II
fluorescence,
NIR-I
photoacoustic,
trimodal
imaging.
They
act
as
radiosensitizers
alleviating
hypoxic
microenvironment,
modulating
cell
cycle,
inducing
apoptosis
immunogenic
death
during
which
may
provide
a
potential
approach
tumors.
Язык: Английский