Regulating excited state of local excitation and charge transfer to boost phototherapeutic effect of AIE-active free radical photosensitizer DOI

Chunwang Guo,

Xue Bai, Zhiguo Ma

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 164068 - 164068

Published: May 1, 2025

Language: Английский

Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy DOI
Long He, Yi Li,

Chonghua Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216549 - 216549

Published: Feb. 27, 2025

Language: Английский

Citations

0
Semiconducting Open‐Shell Radicals for Precise Tumor Activatable Phototheranostics DOI Creative Commons
Jie Zhang,

Haifen Luo,

Wen Ma

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Semiconducting open-shell radicals (SORs) have promising potential for the development of phototheranostic agents, enabling tumor bioimaging and boosting tumorous reactive oxygen species (ROS). Herein, a new class semiconducting perylene diimide (PDI), designated as PDI(Br)n with various numbers bromine (Br) atoms modified on PDI's bay/ortho positions is reported. demonstrated to transform into radical anion, [PDI(Br)n]•-, in reducing solution, typical g-value 2.0022. Specifically, [PDI(Br)4/6]•- generated weakly reductive tumor-mimicking solution exhibits high stability air. Quantum chemical kinetic simulation ultrafast femtosecond transient absorption spectroscopy indicate that [PDI(Br)6]•- has low π-π stacking energy (0.35 eV), fast electron transfer rate (192.4 ps) gap PDI(Br)6 (ΔES1, T1 = 1.307 eV, ΔES1, T2 0.324 eV) respectively, which together result excited-state charge characters. The nanoparticle radicals, [PDI(Br)6] NPs•-, specifically enable chemodynamic type-I photodynamic ROS generation tumors, including superoxide hydroxyl elicit immunogenic cell death effect. Also, NPs•- facilitate activatable bioimaging-guided therapy due their photoacoustic signal at 808 nm NIR-II emission 1115 nm. work paves way design SORs precise cancer theranostics.

Language: Английский

Citations

0
Organic Radiosensitizer with Aggregation-Induced Emission Characteristics for Tumor Ablation through Synergistic Apoptosis and Immunogenic Cell Death DOI
Danni Xie,

Xueke Yan,

Shangping Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Inspired by the clinical application of thermotherapy to promote efficacy radiotherapy, this study demonstrates multimodal diagnostic pure organic nanoparticles in combined treatment tumors through imaging and photothermal properties. The developed demonstrated unique properties multiple functionalities, including excellent photostability thermostability, strong fluorescence emission near-infrared-II (NIR-II) region, extremely high conversion efficiency, good biocompatibility, significant radiosensitizing properties, effective tumor site accumulation. In vitro vivo evaluations that these are ideal candidates for synergistic radiotherapy guided NIR-II fluorescence, NIR-I photoacoustic, trimodal imaging. They act as radiosensitizers alleviating hypoxic microenvironment, modulating cell cycle, inducing apoptosis immunogenic death during which may provide a potential approach tumors.

Language: Английский

Citations

0
Regulating excited state of local excitation and charge transfer to boost phototherapeutic effect of AIE-active free radical photosensitizer DOI

Chunwang Guo,

Xue Bai, Zhiguo Ma

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 164068 - 164068

Published: May 1, 2025

Language: Английский

Citations

0