Engineering a multifunctional core-shell structured cascade nanoreactor for augmented and synergistic carbon monoxide oncotherapy
Science China Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Язык: Английский
Construction of Nitric Oxide-Releasing Poly(trimethylene carbonate)-Based Polymersomes Equipped with Cell-Penetrating Guanidine
Chemistry of Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Язык: Английский
Red‐Light Triggered CO/ROS Release from Porphyrin‐Flavonol Hybrid@PC7A Micelles for Eradicating Escherichia coli
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 12, 2025
Abstract
Photo‐triggered
carbon
monoxide
(CO)
release,
mediated
by
reactive
oxygen
species
(ROS),
shows
a
significant
potential
in
therapeutic
applications.
However,
the
existing
photosensitizers
predominantly
function
as
type
II
ROS
generators.
When
are
present
excess,
they
always
wasted
due
to
their
short
half‐lives,
which
limit
ability
travel
distances
and
effectively
achieve
outcomes.
In
this
study,
biological
of
single‐component
molecule,
PdHF,
is
investigated.
This
molecule
formed
covalently
conjugating
3‐hydroxyflavone
(3‐HF)
palladium(II)
tetraphenyltetrabenzoporphyrin
(PdTPTBP)
photosensitizer.
Subsequently,
PdHF
loaded
into
2‐hexamethyleneimino
ethyl
methacrylate
(C7A)‐modified
PEG‐
b
‐PCL
block
copolymer
(PC7A)
form
PdHF@PC7A
micellar
system
capable
co‐releasing
CO
under
red‐light
irradiation.
CO/ROS
co‐release
can
be
attributed
generation
singlet
that
not
only
oxidize
3‐HF
release
but
concurrently
reduced
tertiary
amine,
C7A,
cytotoxic
superoxide
anions
hydrogen
peroxide.
vitro
studies
on
these
positively
charged
micelles
validate
high
biosafety
excellent
antibacterial
effects
with
competent
elimination
Gram‐negative
bacteria,
Escherichia
coli
.
Furthermore,
evidence
micelle
uptake
bacterial
cells
supports
synergistic
photodynamic
gas
therapy
through
intracellular
co‐release.
Язык: Английский
Carbon Monoxide and Prokaryotic Energy Metabolism
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2809 - 2809
Опубликована: Март 20, 2025
Carbon
monoxide
(CO)
plays
a
multifaceted
role
in
both
physiology
and
pathophysiology.
At
high
levels,
it
is
lethal
to
humans
due
its
tight
binding
globins
cytochrome
c
oxidase.
low
doses,
CO
can
exhibit
beneficial
effects;
serves
as
an
endogenous
signaling
molecule
possesses
antibacterial
properties,
which
opens
up
possibilities
for
use
antimicrobial
agent.
For
this
purpose,
research
progress
develop
metal-based
CO-releasing
molecules,
metal-free
organic
prodrugs,
CO-generating
hydrogel
microspheres.
The
energy
metabolism
of
prokaryotes
key
point
that
may
be
targeted
by
kill
invading
pathogens.
cornerstone
prokaryotic
series
membrane-bound
enzyme
complexes,
constitute
respiratory
chain.
Terminal
oxidases,
at
the
end
chain,
contain
hemes
are
therefore
potential
targets
CO.
However,
area
very
early
stage.
impact
on
bacterial
also
provide
basis
biotechnological
applications
gas
present.
This
review
discusses
molecular
effects
microbial
growth
aerobic
respiration
supported
different
terminal
oxidases
light
recent
findings.
Язык: Английский